DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gycalpha99B and gcy-20

DIOPT Version :9

Sequence 1:	NP_477088.2	Gene:	Gycalpha99B / 43493	FlyBaseID:	FBgn0013972	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	NP_507101.1	Gene:	gcy-20 / 184797	WormBaseID:	WBGene00001545	Length:	1108	Species:	Caenorhabditis elegans

Alignment Length:	892	Identity:	192/892 - (21%)
Similarity:	318/892 - (35%)	Gaps:	304/892 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 VIAEPGGHWALEDEELSDDALTLTHLQMAIQLLTAPSNEDLNTAV-------------TSLVAKY 69
            |.|||.......||  :|..:..:......||:|..:||.:..|.             |::..:|
Worm   255 VFAEPQSRGFYVDE--ADGKVHYSWDDTDGQLVTGLTNEQIRDAYGKVLYICDNMGEPTTITTQY 317

  Fly    70 RQNWPNIHKLKLDPQTF---KSCANYDY---------LAD------------------------- 97
             .|:.:....::..|.|   :.|:|..|         |||
Worm   318 -TNFTSQVISRMAEQPFNCVQDCSNQSYKHAATYAGQLADSFYAYAFALNKSLTQDPTRSNLKNG 381

  Fly    98 ----------------------------IQELLLKMDEA----SASEILVLLGEELIT------- 123
                                        :|..:..|:.:    .|:.:||.:.|.:.|
Worm   382 SFVLSNIGMTFQGVGGEAVTLDESGSRIVQVYMFAMNSSLLPYMAASLLVNVSEVVFTPFYKSES 446

  Fly   124 ------------CCCTGIIERAFRCLGTDLQEFLGSLDGVYDVLKLQEEDVTDTGFV-------- 168
                        |..||:     .|....::|:|     ||.::         ..|:
Worm   447 ELWSVRPLSRPKCGFTGL-----ECPADFVKEYL-----VYTII---------AAFIVILALLAG 492

  Fly   169 CAGEGELIFT-------SERPVIAWLLLGSLKALTRMLYKVDVNIKIEPVEGDARRYRYLFSLVK 226
            |||   |::|       .||..:.|.:               ..::::.|:..:|....:.|...
Worm   493 CAG---LLYTMHMKRKEMERQDLLWQV---------------AFVELQQVQSKSRAEASMHSFAS 539

  Fly   227 DNSQTMLMGRPTSVSKTIPETVQRSN-----------SSNASDLQM-----NSSSFCKMFPWHFI 275
                    |..||...|:....:.:|           ::...||.:     ..|.|.:|..:.
Worm   540 --------GPSTSTKMTVESRTETTNFIFYHYHQEVVAAKKHDLLVLFDANQKSEFRQMRNFD-- 594

  Fly   276 MNEQL-----------ELVQLGRGFSK-LYKPYMADFGCQATTYFDFKRPKGLTMKFRDIVRRTY 328
             |:.|           :|:.|.|..|: .....::....|..::|.|.       ..|||....|
Worm   595 -NDNLNKFIGLCLDGPQLLSLWRFCSRGSLSDVISKSSMQMDSFFMFS-------LIRDISNGLY 651

  Fly   329 ---TPFL---------IGLNNPPGAVDFPAIGLEIKGQMVHCPESNSLLFIGSPFLDGLD----- 376
               :.||         ..|.:....:.....||: ..:....|:...||:....:|...|
Worm   652 FIHSSFLKCHGQLTSRCCLIDDRWQIKISGFGLK-SVRTFENPKKEDLLWASPEYLRNEDQERLP 715

  Fly   377 -------GLTCNGLFI-------------SDIPL-------HDATR------EVILVG------- 401
                   |:.|..:..             .|:.:       |:.||      |.:::.
Worm   716 EGDIYSFGIICAEILTRSSAFDLENRKEKPDVIIYQVKKGGHNPTRPSLDTGETVVINPALLHLV 780

  Fly   402 --------------EQARA-----QDGLRRR-MDKIKNSIE-----------EANSAVTKERKKN 435
                          ||.|:     :||.:.. ||.:.|.:|           :....:|:|:||:
Worm   781 RDCWTERPSERPSIEQVRSHLNGMKDGRKTNLMDHVFNMLETYASTLEEEVSDRTKELTEEKKKS 845

  Fly   436 VSLLHLIFPAEIAEKLWLGSSIDAKTYPDVTILFSDIVGFTSICSRATPFMVISMLEGLYKDFDE 500
            ..||:.:.|..:|:||.||.:::.:|:..|||.|||:|.||::..:.||..|:::|..||..||.
Worm   846 DVLLYRMLPRMVADKLKLGQTVEPETFEQVTIFFSDVVQFTTLAGKCTPLQVVTLLNDLYTIFDG 910

  Fly   501 FCDFFDVYKVETIGDAYCVASGL-HRASIYDAHKVAWMALKMIDACS----KHITHDGEQIKMRI 560
            ..:..||||||||||.|...||| ||........:|.|:|..:.:..    :|:  ..|:|.:||
Worm   911 IIEQNDVYKVETIGDGYLCVSGLPHRNGNDHIRHIARMSLGFLSSLEFFRVQHL--PAERINLRI 973

  Fly   561 GLHTGTVLAGVVGRKMPRYCLFGHSVTIANKFESGSEALKINVSPTTKDWLTKHEGFEFELQPRD 625
            |::.|:|:|||||..||||||||.:|..|::.||..:..:|:|:......||:..| .|..:.|.
Worm   974 GINCGSVVAGVVGLTMPRYCLFGDAVNTASRMESNGKPGQIHVTAEANRMLTQVVG-GFRTESRG 1037

  Fly   626 PSFLPKEFPNPGGTETCYFL-ESFRNPALDSELPLVEHINVSMKTIS 671
            ...:    ...|..||.:.| |.....|.....|.|.....|:::||
Worm  1038 EVII----KGKGVMETFWLLGEESGYTAPSKAAPKVIQHRQSIRSIS 1080

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002	32/234 (14%)
		HNOBA	259..451	CDD:285003	51/296 (17%)
		CYCc	430..619	CDD:214485	78/193 (40%)
		Guanylate_cyc	457..647	CDD:278633	73/195 (37%)
gcy-20	NP_507101.1	PBP1_NPR_GC_like	22..439	CDD:107347	30/186 (16%)
		ANF_receptor	44..418	CDD:279440	25/165 (15%)
		PKc_like	536..801	CDD:304357	44/283 (16%)
		STYKc	562..801	CDD:214568	38/249 (15%)
		HNOBA	<818..861	CDD:285003	10/42 (24%)
		CYCc	840..1032	CDD:214485	78/194 (40%)
		Guanylate_cyc	867..1054	CDD:278633	72/193 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810