DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gycalpha99B and gcy-32

DIOPT Version :9

Sequence 1:	NP_477088.2	Gene:	Gycalpha99B / 43493	FlyBaseID:	FBgn0013972	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	NP_506452.5	Gene:	gcy-32 / 179887	WormBaseID:	WBGene00001552	Length:	684	Species:	Caenorhabditis elegans

Alignment Length:	687	Identity:	166/687 - (24%)
Similarity:	307/687 - (44%)	Gaps:	121/687 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 LNTAVTSLVAK-YRQN-WPNIHKLKLDPQTFKS----CANYDY-------LADIQELLLKMDEAS 109
            ::.::..||.: |.:: |..:    |:...|:|    ..|:.|       |.|...|:||:   :
Worm     5 IHESIRQLVIRNYGEDTWTQV----LERSGFESGKENIMNHYYSDTDTYVLVDSVSLVLKV---T 62

  Fly   110 ASEILVLLGEELITCCCTGIIERAFRCLGTDLQEFLGSLDGVYDVLK--LQEEDVTDTGFVC--A 170
            ..::..:.|..|||.......:...|.:..:|:.||.:||.::..:.  :.:.::....|.|  .
Worm    63 KDQVWEMYGGFLITYSMEIGWDELVRSMSPNLKGFLDNLDSLHYFIDHVVYKANLRGPSFRCEET 127

  Fly   171 GEGELI---FTSERPVIAWLLLGSLKALTRMLYKVDVNIKIE-------PVEGDARRYRYLFSLV 225
            .:|.|:   ||. ||.:..::.|.:|.:.:.::.:|:.:.::       .:....|...::..|:
Worm   128 PDGTLLLHYFTG-RPGLYHIVKGVVKEVAKRVFDLDITLVVQGRTQRSVHMNNGERVEEHVVFLI 191

  Fly   226 ---------KDNSQTMLMGRPTSVSKTIPETVQRSNSSNASDLQMNSSSFCKMFPWHFIMNEQLE 281
                     .:.|:..|:   ||.:...|..|.       ..|.::...|.|..|:||:::|..:
Worm   192 NNLSEPRRDSEGSEVSLL---TSTNANFPTIVD-------DTLGISLDDFSKALPYHFVIDESCK 246

  Fly   282 LVQLGRGF-----SKLYKPYMADFGCQATTYFDFKRPKGLTMKFRDIVRRTYTPFLIGLNNPP-- 339
            |||.|...     ::|.:|     |......|:..||: :.:.|.:|.......|::.:...|
Worm   247 LVQCGSELHNHIPNELLQP-----GTPILRIFEINRPQ-IPLDFENICNFINAVFVLQVKTSPLK 305

  Fly   340 ----------------GAVDFPAIG-------LEIKGQMVHCPESNSLLFIGSPFLDGLDGLTCN 381
                            ..:|..|..       |::||||:.......::::.||::..::.|...
Worm   306 KKHMDAMSQEELKQEMETLDEDATNELTQGHHLKLKGQMMLLASKKHIIYLCSPYVTSINELMQY 370

  Fly   382 GLFISDIPLHDATREVILVGEQARAQDGLRRRMDKIKNSIEEANSAVTKERKKNVSLLHLIFPAE 446
            |:.::.:|||||||::||:.:|..:...:..:::.....:|.....:..||:|..|:|..:.|..
Worm   371 GMRLTAMPLHDATRDLILLNQQRLSDVEVNLQLEANNEQLETMTRELELERQKTDSILKDMLPRR 435

  Fly   447 IAEKLWLGSSIDAKTYPDVTILFSDIVGFTSICSRATPFMVISMLEGLYKDFDEFCDFFDVYKVE 511
            ||::|..|..|:|..: :.|::|.|:..|.....:.:|..:::||..:::..|.......|||||
Worm   436 IAQQLLSGEHIEACEH-EATVMFCDLPAFQQAIPQCSPKDIVNMLNEIFRKLDRIVVIRGVYKVE 499

  Fly   512 TIGDAYCVASGL------HRASI-YDAHKVAWMALKMIDACSKHITHDGEQIKMRIGLHTGTVLA 569
            |:.|:|...||:      |..:: :.|..:.|.|..:||..||      ....:|||:|:||:.|
Worm   500 TVSDSYMAVSGIPDYTPEHAENMCHVALGMMWEARSVIDPVSK------TPFLLRIGIHSGTITA 558

  Fly   570 GVVGRKMPRYCLFGHSVTIANKFESGSEALKINVSPTTKDWLTKH--EGFEFELQPRDPSFLPKE 632
            ||||...|:|||||.:||:|::.||...|.||..|    .|..:.  |...||..||...    :
Worm   559 GVVGTVHPKYCLFGETVTLASQMESLGMAGKIQCS----KWAYQKAMETGRFEFSPRGRI----D 615

  Fly   633 FPNPGGTETCYFLESFRNPALDSELPLVEH---INVS 666
            ....|.|||.:...|.:.    |...:::|   |||:
Worm   616 VKQRGLTETYFLTRSLKK----SIWEIIDHDRDINVN 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002	31/149 (21%)
		HNOBA	259..451	CDD:285003	51/221 (23%)
		CYCc	430..619	CDD:214485	66/197 (34%)
		Guanylate_cyc	457..647	CDD:278633	64/198 (32%)
gcy-32	NP_506452.5	HNOB	3..167	CDD:285002	35/169 (21%)
		HNOBA	226..440	CDD:285003	50/219 (23%)
		CYCc	419..608	CDD:214485	67/199 (34%)
		Guanylate_cyc	452..627	CDD:278633	62/188 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820