DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gycalpha99B and acy-4

DIOPT Version :9

Sequence 1:	NP_477088.2	Gene:	Gycalpha99B / 43493	FlyBaseID:	FBgn0013972	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	NP_504486.4	Gene:	acy-4 / 178949	WormBaseID:	WBGene00000071	Length:	1013	Species:	Caenorhabditis elegans

Alignment Length:	486	Identity:	107/486 - (22%)
Similarity:	180/486 - (37%)	Gaps:	140/486 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 FSLVKDNSQTMLMGRPTS--VSKTIPETVQRSNSSNASDLQMNSSSFCKM---------FPW--- 272
            ::.::.:.||.:..||.|  .|.|:.||.   .|....:|:|.:...|..         |||
Worm     6 YNSIRAHKQTRVAQRPVSKKTSSTMRETF---GSQVLRELEMKNRMECPSLDEILSFYHFPWEKL 67

  Fly   273 HFIMNEQ-----------LELVQLGR---GFSKLYKPYMAD-----FG---------CQAT---- 305
            .:..|.|           .|.|..||   .|..|....:::     ||         |..|
Worm    68 RYRKNSQKKKRSTLYSFYFEQVNSGRIQFSFVILLSICISEAAFSAFGAEWLKSLILCILTLVIS 132

  Fly   306 --TYFDFKRPK---------------------------------GLTMKFRDIVRRTYT-PFLIG 334
              ::|..||.:                                 .|.|.|..::..|:. .||:.
Worm   133 ILSFFHAKRTELVCIASIISCVIISACTSMRTSVTYLLIFSTYSLLPMSFMLMIFSTFALTFLVA 197

  Fly   335 LNNPPGAVDFPAIGLEI-------------KGQMVHCPESNSLLFIGSPFLDGLDGLTCNGLFIS 386
            .   .|.:....:|.:|             .|.:|:.|..                      |:.
Worm   198 F---IGVLMDYNVGFDIILTRVMMVILVNVVGSLVYYPTE----------------------FVQ 237

  Fly   387 DIPLHDATREVILVGEQAR-AQDGLRRRMDKIKNSIEEANSAVTKERKKNVSLLHLIFPAEIAEK 450
            ....|: ||:.:    |:| ..|....|.:||..::...|.|.  |.||::...|       .|:
Worm   238 RKTFHE-TRKCV----QSRMLLDKEMHRQEKILLAVLPKNIAF--EVKKDMQETH-------EER 288

  Fly   451 LWLGSSIDAKTYPDVTILFSDIVGFTSICSRATPFMVISMLEGLYKDFDEFCDFFDVYKVETIGD 515
            ::  ..|..:.|.|::|||:||.|||::.|...|..::.||..|:..||:........:::.:||
Worm   289 MF--HKIYIRKYEDISILFADICGFTNLASEYNPKDLVLMLNELFARFDKVASIHQCMRIKILGD 351

  Fly   516 AYCVASGLHRASIYDAHKVAWMALKMIDACSKHITHDGEQIKMRIGLHTGTVLAGVVGRKMPRYC 580
            .|....|:.......|.....|...||:|...........:.||:|:|||....||:|.|..::.
Worm   352 CYYCVCGVPEYQKNHAINTVEMGRDMIEAIRLVREMTLVNVNMRVGIHTGKAHCGVLGLKKWQFD 416

  Fly   581 LFGHSVTIANKFESGSEALKINVSPTTKDWL 611
            ::.:.||:||:.|||..|.:::::..|:.:|
Worm   417 VWSNDVTLANQMESGGLAGRVHITDATRSYL 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002
		HNOBA	259..451	CDD:285003	50/285 (18%)
		CYCc	430..619	CDD:214485	52/182 (29%)
		Guanylate_cyc	457..647	CDD:278633	47/155 (30%)
acy-4	NP_504486.4	AC_N	<50..291	CDD:292831	48/281 (17%)
		CYCc	260..451	CDD:214485	57/199 (29%)
		Guanylate_cyc	293..448	CDD:278633	47/155 (30%)
		CYCc	778..984	CDD:214485
		Guanylate_cyc	807..1003	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810