Protein Alignment Gycalpha99B and gcy-18

DIOPT Version :10

• Sequence 1: NP_477088.2
• Gene: Gycalpha99B / 43493
• FlyBaseID: FBgn0013972
• Length: 676
• Species: Drosophila melanogaster
• Sequence 2: NP_502449.2
• Gene: gcy-18 / 178237
• WormBaseID: WBGene00001543
• Length: 1113
• Species: Caenorhabditis elegans
• Alignment Length: 635
• Identity: 167/635 - (26%)
• Similarity: 251/635 - (39%)
• Gaps: 161/635 - (25%)

  Fly    58 LNTAVTSLVAKYRQNWPNIHKLKLDPQTFKSCANYDYLADIQELLLKMDEASASEILVLLG---- 118
            :||..|  ..:|:|..| |..:|.|.|                ||.:|.:|....:...||
 Worm   576 VNTHTT--YHRYKQRRP-IKFIKEDMQ----------------LLTQMKQAVHDNLNPFLGAAFN 621

  Fly   119 --EELITC---CCTGIIERAFRCLGTDLQE-FLGSLDGVYDV-LKLQEEDVTDTGFVCAGEGELI 176
              ||::..   |..|.|:.........|.| |.|:.  |.|: |.|:....:..|:    .|.|
 Worm   622 EKEEMLVLWKFCSRGTIQDIIYNANVVLDEKFHGAF--VRDITLGLEYLHASPIGY----HGSL- 679

  Fly   177 FTSERPVIAWLLLGSLKALTRMLYKVDVN--IKI------EPVEGDARRYRYLFSLVKDNSQTML 233
                   ..|..|            :|.|  :|:      .|:|...::.....:..||:.....
 Worm   680 -------TPWCCL------------IDRNWMVKLSDYGIANPLERWEKQGAIEIAAAKDSDDKSQ 725

  Fly   234 MGRPTSVSKTIPETVQRSNSSNASDLQMNSSSFCKMFPWHFIMNEQLELVQLGRGFSKLYKPYMA 298
            ..:.||:....||.::...::....:..:         |       ::...|.|
 Worm   726 ASQATSIIYMAPELLKNRETNKRRGMDQS---------W-------VKQSMLRR----------- 763

  Fly   299 DFGCQATTYFDFKRPKGLTM---KFRDIVRRTYTPFLIGLNNPPGAVDFPAIGL-----EIKGQM 355
                ||...:.|    |:.|   .||.:..|..|       |....||:.|.|.     ||:.||
 Worm   764 ----QAGDIYSF----GMVMYEILFRSLPFRDNT-------NISELVDYLADGSKTVSPEIQNQM 813

  Fly   356 VHCPESNSLLFIGSPFLDGLDGLTCNGLFISDIPLHDATREVILVGE-----QARAQDGLRRRMD 415
            ...|:.|:||               ...:..:..:..:.|.|.|..|     :....|.:.:.|:
 Worm   814 GLHPDLNALL---------------RDCWSENPEIRPSIRRVRLNTEMVLKTKGSLVDQMMKMME 863

  Fly   416 KIKNSIE----EANSAVTKERKKNVSLLHLIFPAEIAEKLWLGSSIDAKTYPDVTILFSDIVGFT 476
            :..|::|    |....:.:...:...||..:.||.:|.:|.:|.|:..|.|...|||||||||||
 Worm   864 QYANNLEKLVAERTGMLEEANIRADQLLTQLLPAYVANELKMGRSVAPKLYSSATILFSDIVGFT 928

  Fly   477 SICSRATPFMVISMLEGLYKDFDEFCDFFDVYKVETIGDAYCVASGLHRASIYD-AHKVAWMALK 540
            :|||.:||..|::||.|||..|||.......||||||||||.|.||:...:.|: :..:|..||.
 Worm   929 TICSGSTPLEVVNMLNGLYTGFDECITRNKSYKVETIGDAYMVVSGIPEENEYNHSRNIANTALD 993

  Fly   541 MIDACSKH-ITH-DGEQIKMRIGLHTGTVLAGVVGRKMPRYCLFGHSVTIANKFESGSEALKINV 603
            |....:.: |.| ...:::.|.|.|||:|.|||||...|||||||.:|.::::.||......|.:
 Worm   994 MRQYLTGYQIPHRPTHRVRCRWGFHTGSVAAGVVGLTCPRYCLFGDTVNVSSRMESTGTPGMIQM 1058

  Fly   604 SPTTKDWLTKHEGFEFELQPRDPSFLPKEFPNPG-----GTETC--YFLE 646
            |          |.....::...|.|...|   .|     |..||  ::||
 Worm  1059 S----------EEAHMHIRAHHPVFTTTE---RGEVQVKGKGTCRTFWLE 1095

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	<109..208	CDD:462233	22/111 (20%)
		HNOBA	259..451	CDD:462234	39/208 (19%)
		Guanylate_cyc	457..647	CDD:425528	80/200 (40%)
gcy-18	NP_502449.2	PBP1_NPR_GC-like	64..446	CDD:380575
		Protein Kinases, catalytic domain	549..846	CDD:473864	73/371 (20%)
		CYCc	882..1073	CDD:214485	80/200 (40%)