DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gycalpha99B and gcy-12

DIOPT Version :9

Sequence 1:	NP_477088.2	Gene:	Gycalpha99B / 43493	FlyBaseID:	FBgn0013972	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	NP_494995.2	Gene:	gcy-12 / 173902	WormBaseID:	WBGene00001538	Length:	1679	Species:	Caenorhabditis elegans

Alignment Length:	596	Identity:	149/596 - (25%)
Similarity:	240/596 - (40%)	Gaps:	173/596 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 RAFRCLG-TDLQEFLGSLDGVYDVLKLQEEDVTDTGFVCAGEGELIFTSERPVIAWLLLGSLKAL 195
            ||.|.|. .::..|||.:...|.|..::|        .|:                  .|||..:
Worm   716 RAMRQLAHPNVNNFLGIIVCQYSVTVVRE--------YCS------------------KGSLHDI 754

  Fly   196 TRMLYKVDVNIKIEPVEGDARRYRYLFSLVKDNSQTMLMGRPTSVSKTIPETVQRSNSSNASDLQ 260
            .|     :.|:|::        :.|:.|.|.|..:.|:.                   .:.|:|:
Worm   755 LR-----NENLKLD--------HMYVASFVDDLVKGMVY-------------------IHDSELK 787

  Fly   261 MN---SSSFCKMFPWHFIMNEQLELVQLGRGFSKLYKPYMADFGCQATTYFDFKRPKGLTMKFRD 322
            |:   .|:.|       ::..:..|.....|..:|.:..|.|........|.:..|:.:|:...
Worm   788 MHGNLKSTNC-------LITSRWTLQIADFGLRELREGIMYDSSYNIWENFLWTAPEAMTINGS- 844

  Fly   323 IVRRTYTPFLIGLNNPP----GAVDFPAIGLEIKGQMVHCPESNSLLFIGSPFLDG-----LDGL 378
                      :.::|||    .|..|..|..||     ...|....:::....::|     .|.:
Worm   845 ----------LAISNPPTPKADAYSFGIIFHEI-----FTREGPYKIYVQRGDVNGEAAPKKDSV 894

  Fly   379 TCNGLF----------------ISDIPLHDATREVIL--------------------------VG 401
            .|..|.                .||:.:.:..:||:.                          :.
Worm   895 ECRALVEKTVRRVYSDPYFRPDTSDLEVQNYVKEVMAACWHHDPYQRPEFKTIKNKLKPLFHQIY 959

  Fly   402 EQARAQDGLRRRMDK----IKNSIEEANSAVTKERKKNVSLLHLIFPAEIAEKLWLGSSIDAKTY 462
            :| ...|.:...|:|    :::.::|....:..|::::..||..:.|:.:||:|..|..:..:.:
Worm   960 KQ-NIMDHMVLMMEKYQTQLEDLVDERTIELKDEQRRSQHLLQRMLPSSVAEQLLAGQDVIPEAF 1023

  Fly   463 PDVTILFSDIVGFTSICSRATPFMVISMLEGLYKDFDEFCDFFDVYKVETIGDAYCVASGL--HR 525
            |.|||.||||||||:|...:||..|::.|..||..||.....:||||||||||||.|.||:  ::
Worm  1024 PPVTIYFSDIVGFTTISGESTPMEVVTFLNKLYTLFDSIIRRYDVYKVETIGDAYMVVSGVPQYK 1088

  Fly   526 ASIYDAHKVAWMALKMIDAC-SKHITHDG-EQIKMRIGLHTGTVLAGVVGRKMPRYCLFGHSVTI 588
            ...|.|.::|.||:.::.|. |..|.|.. |.:.:|||:|||..:|||||:.||||.|||.:|..
Worm  1089 TMEYHAEQIAMMAIHILSAVRSFSIPHRSCEPLMIRIGMHTGPCVAGVVGKTMPRYTLFGDTVNT 1153

  Fly   589 ANKFESGSEALKINVSPTTKD----------------------------WLTKHEGFEFELQPRD 625
            |::.||..|||:|:.|.:|:.                            ||....|:||.....|
Worm  1154 ASRMESNGEALRIHCSSSTQKVLTSIDQGFLLEERGSLAIKGKGQMTTYWLNGRAGYEFTETIED 1218

  Fly   626 PSFLPKEFPNP 636
            ...:|..||.|
Worm  1219 KMVVPDIFPRP 1229

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002	16/76 (21%)
		HNOBA	259..451	CDD:285003	40/249 (16%)
		CYCc	430..619	CDD:214485	85/220 (39%)
		Guanylate_cyc	457..647	CDD:278633	84/212 (40%)
gcy-12	NP_494995.2	PBP1_Speract_GC_like	123..545	CDD:107365
		ANF_receptor	140..519	CDD:279440
		PK_GC-A_B	648..957	CDD:270944	52/321 (16%)
		TyrKc	688..951	CDD:197581	52/315 (17%)
		HNOBA	<967..1012	CDD:285003	9/44 (20%)
		CYCc	991..1183	CDD:214485	82/191 (43%)
		Guanylate_cyc	1018..1206	CDD:278633	76/187 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810