Protein Alignment Gycalpha99B and gcy-35

DIOPT Version :10

• Sequence 1: NP_477088.2
• Gene: Gycalpha99B / 43493
• FlyBaseID: FBgn0013972
• Length: 676
• Species: Drosophila melanogaster
• Sequence 2: NP_001252131.1
• Gene: gcy-35 / 173202
• WormBaseID: WBGene00001555
• Length: 688
• Species: Caenorhabditis elegans
• Alignment Length: 645
• Identity: 183/645 - (28%)
• Similarity: 296/645 - (45%)
• Gaps: 96/645 - (14%)

  Fly    48 QLLTAPSNEDLNTAVTSLVAKYRQNWPNI-HKLKLDPQTFKSCANYDYLADIQELLLKMDEASA- 110
            ||:|....:|:              |..| |..|.:..|....|:  |..|.:.|.|....|:.
 Worm    11 QLVTRKYGKDI--------------WEKIVHMSKFELGTESEIAH--YYNDDETLRLVNSMANVI 59

  Fly   111 ----SEILVLLGEELITCCCTGIIERAFRCLGTDLQEFLGSLDGVYDVLK--LQEEDVTDTGFVC 169
                .||....|..||........:...|.:..||:.||.|||.::..:.  :.:..:....|.|
 Worm    60 GIPIEEIWEAYGGFLIQFTMETGWDELLRAMAPDLEGFLDSLDSLHYFIDHVVYKTKLRGPSFRC 124

  Fly   170 --AGEGELI--FTSERPVIAWLLLGSLKALTRMLYKVDVNIKIEPVEGDARRYRYLFSLVKDNSQ 230
              ..:|.|:  :.|:|..:..::.|.::.:.|.:|..:|.:|::     .|:..:|.:.|.:: .
 Worm   125 DVQADGTLLLHYYSKRSGLYPIVKGVVREVARRIYDTEVVMKVQ-----ERKQEHLDAFVTEH-V 183

  Fly   231 TMLMGRPTSVSKTIPETVQRSNSSNASDL-----QMNSSSFCKMFPWHFIMNEQLELVQLGRGFS 290
            ..::.:..:.:.|.|:::. |.:.:..||     :::||.|...||:|...:..|.:...|....
 Worm   184 VFVITQIENANSTQPKSIS-SKADSQIDLSTGIYEISSSDFSLAFPYHICFDPDLFVEHFGNFIK 247

  Fly   291 KLYKPYMADFGCQAT---------------TYFDFKRPKGLTMKFRDIVRRTYTPFLIGLNNPPG 340
            |.:...|.    |.|               :|...|..|.....||          |.||.:...
 Worm   248 KTFPNAMR----QETRVTDLLELVHPEVPFSYESIKYYKNSLFVFR----------LKGLGDIVH 298

  Fly   341 AVDFPAIGLEIKGQMVHCPESNSLLFIGSPFLDGLDGLTCNGLFISDIPLHDATREVILVGEQAR 405
            ..:..|..:.:||.||...|...:|::.|..:..:..|....|.:||:..||.||:||::.:...
 Worm   299 NANDEAKTVLLKGSMVFIDEGKYILYMCSVNVTTVRELIERNLHLSDMQRHDGTRDVIMLNQSRM 363

  Fly   406 AQDGLRRRMDKIKNSIEEANSAVTKERKKNVSLLHLIFPAEIAEKLWLGSSIDAKTYPDVTILFS 470
            :|..|.|.:::....:::....:..|::|...||..:.||.:|:.|..|.::|||.:.|.|:||:
 Worm   364 SQVELNRTLEETTKKLKKMAQELEIEKQKTDELLCELMPASVADSLRSGKAMDAKEFADCTLLFT 428

  Fly   471 DIVGFTSICSRATPFMVISMLEGLYKDFDEFCDFFDVYKVETIGDAYCVASGLHRASIYDAHKVA 535
            |||.||:||:..||:.|:::|..||..||......|.||||||||||.:..|:.......|.:|.
 Worm   429 DIVTFTNICAMCTPYDVVTLLNDLYLRFDRLVGLHDAYKVETIGDAYMIVGGVPERCENHAERVL 493

  Fly   536 WMALKMI---DACSKHITHDGEQIKMRIGLHTGTVLAGVVGRKMPRYCLFGHSVTIANKFESGSE 597
            .:::.|:   ......|||  :.||:|:|:|.|.|:|||||.|||||||||.:|.:|||.||...
 Worm   494 NISIGMLMESKLVLSPITH--KPIKIRLGVHCGPVVAGVVGIKMPRYCLFGDTVNVANKMESNGI 556

  Fly   598 ALKINVSPTTKDWLTKHEGFEFELQPRDPSFLPKEFPNPGGTET-------CYFLESFRN 650
            ..||:||.|     .|..|.:     .:||::   |.:.|.||.       .||||  ||
 Worm   557 QCKIHVSET-----GKLNGLK-----ANPSYV---FIDRGNTEIRGKGMMYTYFLE--RN 601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	<109..208	CDD:462233	23/109 (21%)
		HNOBA	259..451	CDD:462234	49/211 (23%)
		Guanylate_cyc	457..647	CDD:425528	83/199 (42%)
gcy-35	NP_001252131.1	HNOB	3..167	CDD:462233	38/171 (22%)
		HNOBA	218..409	CDD:462234	48/204 (24%)
		CYCc	388..579	CDD:214485	85/205 (41%)