DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gycalpha99B and gcy-35

DIOPT Version :9

Sequence 1:	NP_477088.2	Gene:	Gycalpha99B / 43493	FlyBaseID:	FBgn0013972	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	NP_001252131.1	Gene:	gcy-35 / 173202	WormBaseID:	WBGene00001555	Length:	688	Species:	Caenorhabditis elegans

Alignment Length:	645	Identity:	183/645 - (28%)
Similarity:	296/645 - (45%)	Gaps:	96/645 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 QLLTAPSNEDLNTAVTSLVAKYRQNWPNI-HKLKLDPQTFKSCANYDYLADIQELLLKMDEASA- 110
            ||:|....:|:              |..| |..|.:..|....|:  |..|.:.|.|....|:.
Worm    11 QLVTRKYGKDI--------------WEKIVHMSKFELGTESEIAH--YYNDDETLRLVNSMANVI 59

  Fly   111 ----SEILVLLGEELITCCCTGIIERAFRCLGTDLQEFLGSLDGVYDVLK--LQEEDVTDTGFVC 169
                .||....|..||........:...|.:..||:.||.|||.::..:.  :.:..:....|.|
Worm    60 GIPIEEIWEAYGGFLIQFTMETGWDELLRAMAPDLEGFLDSLDSLHYFIDHVVYKTKLRGPSFRC 124

  Fly   170 --AGEGELI--FTSERPVIAWLLLGSLKALTRMLYKVDVNIKIEPVEGDARRYRYLFSLVKDNSQ 230
              ..:|.|:  :.|:|..:..::.|.::.:.|.:|..:|.:|::     .|:..:|.:.|.:: .
Worm   125 DVQADGTLLLHYYSKRSGLYPIVKGVVREVARRIYDTEVVMKVQ-----ERKQEHLDAFVTEH-V 183

  Fly   231 TMLMGRPTSVSKTIPETVQRSNSSNASDL-----QMNSSSFCKMFPWHFIMNEQLELVQLGRGFS 290
            ..::.:..:.:.|.|:::. |.:.:..||     :::||.|...||:|...:..|.:...|....
Worm   184 VFVITQIENANSTQPKSIS-SKADSQIDLSTGIYEISSSDFSLAFPYHICFDPDLFVEHFGNFIK 247

  Fly   291 KLYKPYMADFGCQAT---------------TYFDFKRPKGLTMKFRDIVRRTYTPFLIGLNNPPG 340
            |.:...|.    |.|               :|...|..|.....||          |.||.:...
Worm   248 KTFPNAMR----QETRVTDLLELVHPEVPFSYESIKYYKNSLFVFR----------LKGLGDIVH 298

  Fly   341 AVDFPAIGLEIKGQMVHCPESNSLLFIGSPFLDGLDGLTCNGLFISDIPLHDATREVILVGEQAR 405
            ..:..|..:.:||.||...|...:|::.|..:..:..|....|.:||:..||.||:||::.:...
Worm   299 NANDEAKTVLLKGSMVFIDEGKYILYMCSVNVTTVRELIERNLHLSDMQRHDGTRDVIMLNQSRM 363

  Fly   406 AQDGLRRRMDKIKNSIEEANSAVTKERKKNVSLLHLIFPAEIAEKLWLGSSIDAKTYPDVTILFS 470
            :|..|.|.:::....:::....:..|::|...||..:.||.:|:.|..|.::|||.:.|.|:||:
Worm   364 SQVELNRTLEETTKKLKKMAQELEIEKQKTDELLCELMPASVADSLRSGKAMDAKEFADCTLLFT 428

  Fly   471 DIVGFTSICSRATPFMVISMLEGLYKDFDEFCDFFDVYKVETIGDAYCVASGLHRASIYDAHKVA 535
            |||.||:||:..||:.|:::|..||..||......|.||||||||||.:..|:.......|.:|.
Worm   429 DIVTFTNICAMCTPYDVVTLLNDLYLRFDRLVGLHDAYKVETIGDAYMIVGGVPERCENHAERVL 493

  Fly   536 WMALKMI---DACSKHITHDGEQIKMRIGLHTGTVLAGVVGRKMPRYCLFGHSVTIANKFESGSE 597
            .:::.|:   ......|||  :.||:|:|:|.|.|:|||||.|||||||||.:|.:|||.||...
Worm   494 NISIGMLMESKLVLSPITH--KPIKIRLGVHCGPVVAGVVGIKMPRYCLFGDTVNVANKMESNGI 556

  Fly   598 ALKINVSPTTKDWLTKHEGFEFELQPRDPSFLPKEFPNPGGTET-------CYFLESFRN 650
            ..||:||.|     .|..|.:     .:||::   |.:.|.||.       .||||  ||
Worm   557 QCKIHVSET-----GKLNGLK-----ANPSYV---FIDRGNTEIRGKGMMYTYFLE--RN 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002	33/143 (23%)
		HNOBA	259..451	CDD:285003	49/211 (23%)
		CYCc	430..619	CDD:214485	83/191 (43%)
		Guanylate_cyc	457..647	CDD:278633	83/199 (42%)
gcy-35	NP_001252131.1	HNOB	3..167	CDD:285002	38/171 (22%)
		HNOBA	218..409	CDD:285003	48/204 (24%)
		CYCc	388..579	CDD:214485	85/205 (41%)
		Guanylate_cyc	415..599	CDD:278633	82/198 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920