DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gycalpha99B and Gucy2e

DIOPT Version :9

Sequence 1:	NP_477088.2	Gene:	Gycalpha99B / 43493	FlyBaseID:	FBgn0013972	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	XP_036012232.1	Gene:	Gucy2e / 14919	MGIID:	105123	Length:	1139	Species:	Mus musculus

Alignment Length:	645	Identity:	162/645 - (25%)
Similarity:	269/645 - (41%)	Gaps:	160/645 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 PGGHWALEDEELSDDALTLTHLQMAIQLLTAPSNEDLNTAVTSLVAKYRQNW------PNIHKLK 80
            |||    ...::...:.:....:.|..:.:.||....:|.    |..|..:|      |..|.:.
Mouse   550 PGG----SSRKVVQGSRSSLATRSASDIRSVPSQPQESTN----VGLYEGDWVWLKKFPGEHHMA 606

  Fly    81 LDPQTFKSCANYDYLADIQE----LLLKMDEASASEILVLLGEELITCCCTGIIERAFRCLGTDL 141
            :.|.|..:   :..|.:::.    |.|.:..|..::.....||.::..    :.|...|
Mouse   607 IRPATKTA---FSKLRELRHENVALYLGLFLAGTADSPATPGEGILAV----VSEHCAR------ 658

  Fly   142 QEFLGSLDGVYDVLKLQEEDVTDTGFVCAGEGELIFTSERPVIAWLLLGSLKALTRMLYKVDVNI 206
                |||   :|:|..:|..:           :.:|.|.      |||..:|.:..:.::...:.
Mouse   659 ----GSL---HDLLAQREIKL-----------DWMFKSS------LLLDLIKGMRYLHHRGVAHG 699

  Fly   207 KIEP----VEGDARRYRYLFSLVKDNSQTMLMGRPTSVSKTIPETVQRSNSSNASD--------- 258
            :::.    |:|     |::.. |.|:..    ||.....:.:||      ..:|.|
Mouse   700 RLKSRNCVVDG-----RFVLK-VTDHGH----GRLLEAQRVLPE------PPSAEDQLWTAPELL 748

  Fly   259 ----LQMNSSSFCKMFPWHFIMNEQLELVQLGRGFSKLYKPYMADFGCQATTYFDFKRPKGLTMK 319
                |:...:....:|....||.|.:                     |::|.|      ..|.:.
Mouse   749 RDPSLERRGTLAGDVFSLAIIMQEVV---------------------CRSTPY------AMLELT 786

  Fly   320 FRDIVRRTYTPFLIGLNNPP---GAVDFPAIGLEIKGQMVHC----PESNSLLFIGSPFLDGLDG 377
            ..::::|..:|       ||   ..|......:|....|..|    ||..       |.:|
Mouse   787 PEEVIQRVRSP-------PPLCRPLVSMDQAPMECIQLMTQCWAEHPELR-------PSMD---- 833

  Fly   378 LTCNGLFISDIPLHDATREVILVGEQARAQDGLRRRMDKIKNSIE----EANSAVTKERKKNVSL 438
            ||.: ||.|           |..|.:....|.:.|.:::..:::|    |....:.:|::|...|
Mouse   834 LTFD-LFKS-----------INKGRKTNIIDSMLRMLEQYSSNLEDLIRERTEELEQEKQKTDRL 886

  Fly   439 LHLIFPAEIAEKLWLGSSIDAKTYPDVTILFSDIVGFTSICSRATPFMVISMLEGLYKDFDEFCD 503
            |..:.|..:||.|.:|:|::.:.:.:||:.||||||||:|.:.:.|..|:.:|..||..||....
Mouse   887 LTQMLPPSVAEALKMGTSVEPEYFEEVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIG 951

  Fly   504 FFDVYKVETIGDAYCVASGL-HRASIYDAHKVAWMALKMIDAC-SKHITHDGE-QIKMRIGLHTG 565
            ..||||||||||||.||||| .|.....|.::|.|:|.::.|. |..:.|..| .:::|||||:|
Mouse   952 AHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGSFRMRHMPEVPVRIRIGLHSG 1016

  Fly   566 TVLAGVVGRKMPRYCLFGHSVTIANKFESGSEALKINVSPTTKDWL-TKHEGFEFELQPR 624
            ..:|||||..||||||||.:|..|::.||.....:|:|:.:|...| ...:||:.|.:.|
Mouse  1017 PCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNMSTVRILRALDQGFQMECRGR 1076

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002	23/135 (17%)
		HNOBA	259..451	CDD:285003	39/202 (19%)
		CYCc	430..619	CDD:214485	83/192 (43%)
		Guanylate_cyc	457..647	CDD:278633	75/172 (44%)
Gucy2e	XP_036012232.1	PBP1_sensory_GC_DEF-like	58..465	CDD:380594
		PK_GC-2D	570..845	CDD:270945	69/388 (18%)
		HNOBA	<854..899	CDD:400168	10/44 (23%)
		CYCc	879..1070	CDD:214485	82/190 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810