DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gycalpha99B and gucy2d

DIOPT Version :9

Sequence 1:	NP_477088.2	Gene:	Gycalpha99B / 43493	FlyBaseID:	FBgn0013972	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	XP_005165318.1	Gene:	gucy2d / 140426	ZFINID:	ZDB-GENE-011128-9	Length:	1141	Species:	Danio rerio

Alignment Length:	668	Identity:	160/668 - (23%)
Similarity:	263/668 - (39%)	Gaps:	180/668 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LEDEELSDDALTLTHLQMAIQLLTAPSNEDL-NTAVTSLVAKYRQNWPNIHKLKLDPQTFKSCAN 91
            |...:|:|:::..:.|.:.....:......: :|..||.||.:..:|          ...|.|..
Zfish   560 LSRRKLNDESMLKSQLDVKTPRHSVSGRSYITSTPETSNVAVFEGDW----------VWLKKCPC 614

  Fly    92 YDYLADIQELLLKMDEASASEILVLLGEELITCCCTGIIERAFRCLGTDLQEFLGSL--DGVYDV 154
            .|.:.:|.|        |...|.|.|              |..|  ..:|..|||..  .|::.:
Zfish   615 ADSITEISE--------STQTIFVKL--------------RDMR--HENLNLFLGLFMDTGIFGI 655

  Fly   155 LKLQEEDVTDTGFVCAGEGELIFTSERPVIAW-----LLLGSLKALTRMLYKVDVNIKIEP---- 210
            :         |.....|..|.:..:|...:.|     |||..::.:..:..:..::.:::.
Zfish   656 V---------TEHCTRGSLEDLLNNEEMRLDWMFKSSLLLDLIRGMKYLHNRGIIHGRLKSRNCV 711

  Fly   211 VEGDARRYRYLFSLVKD-------NSQTMLM--GRPTSVSKTIPETVQRSNSSNASDLQMNSSSF 266
            |:|     |::.. |.|       |.|.:::  ..|.....|.||.::.      .||:...:..
Zfish   712 VDG-----RFVLK-VTDYGFNEILNCQNIILEDNAPEDQFWTAPEILRN------PDLKKKGTYP 764

  Fly   267 CKMFPWHFIMNEQLELVQLGRGFSKLYKPYMADFGCQATTYFDFKRPKGLTMKFRDIVRRTYTPF 331
            ..::.:..||.|.:.              ..|.| |.            |.|...:|:.:..:|
Zfish   765 GDVYSFSIIMQEVIS--------------RCAPF-CM------------LDMPPEEIIEKVRSP- 801

  Fly   332 LIGLNNPPGAVDFPAIGLEIKGQMVHCPESNSLLFIGSPFLDGLDGLTCNGLFISDIPLHDATRE 396
                  ||  :..|.:.::      ..|               ||.:.......|:.|....|.|
Zfish   802 ------PP--LCRPTVSMD------EAP---------------LDVIQLMKQAWSEEPEQRPTFE 837

  Fly   397 VIL-------VGEQARAQDGLRRRMDKIKNSIE----EANSAVTKERKKNVSLLHLIFPAEIAEK 450
            .|.       .|::....|.:.|.:::..:::|    |....:..||:|..:||..:.|..:|..
Zfish   838 DIFRQFKSMNKGKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEVERQKTDALLAQMLPKSVALA 902

  Fly   451 LWLGSSIDAKTYPDVTILFSDIVGFTSICSRATPFMVISMLEGLYKDFDEFCDFFDVYKVETIGD 515
            |..|..:..:.:.:||:.||||||||:|.:.:.|..|:.:|..||..||......||||||||||
Zfish   903 LKTGKPVKPEHFAEVTLYFSDIVGFTTISALSEPIEVVDLLNDLYTHFDGIIAIHDVYKVETIGD 967

  Fly   516 AYCVASGL-HRASIYDAHKVAWMALKMIDACS----KHITHDGEQIKMRIGLHTGTVLAGVVGRK 575
            ||.||||: :|.....|.::|.|:|.::....    :|:  ...::|:|||||:|.|:|||||.|
Zfish   968 AYMVASGVPNRNGTRHAAEMANMSLDILHCIGTFKMRHM--PDVKVKIRIGLHSGPVVAGVVGLK 1030

  Fly   576 MPRYCLFGHSVTIANKFESGSEALKINVSPTTKD----------------------------WLT 612
            ||||||||.:|..|::.||.....:|:|:.:|.|                            ||.
Zfish  1031 MPRYCLFGDTVNTASRMESTGLPYRIHVNQSTVDVLNSLKLGYKIDTRGRTELKGKGVEETFWLV 1095

  Fly   613 KHEGFEFELQPRDPSFLP 630
            ..:||:..| |..|...|
Zfish  1096 GRDGFDKPL-PIPPDLTP 1112

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002	24/138 (17%)
		HNOBA	259..451	CDD:285003	34/202 (17%)
		CYCc	430..619	CDD:214485	83/221 (38%)
		Guanylate_cyc	457..647	CDD:278633	78/207 (38%)
gucy2d	XP_005165318.1	PBP1_sensory_GC_DEF_like	78..470	CDD:107366
		PK_GC-2D	581..849	CDD:270945	64/379 (17%)
		HNOBA	<858..903	CDD:311573	10/44 (23%)
		CYCc	883..1075	CDD:214485	79/193 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910