DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gycalpha99B and Npr2

DIOPT Version :9

Sequence 1:	NP_477088.2	Gene:	Gycalpha99B / 43493	FlyBaseID:	FBgn0013972	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	NP_446290.1	Gene:	Npr2 / 116564	RGDID:	620851	Length:	1047	Species:	Rattus norvegicus

Alignment Length:	773	Identity:	198/773 - (25%)
Similarity:	301/773 - (38%)	Gaps:	232/773 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 TFKSCANYDYLADIQELLLKMDEASASEILVLLGEELITCCCTGIIERAFRCLGTDLQEFLGSLD 149
            |::...|.:|......||::..|....|:...|...:..|...||:..| :.|...:||.....|
  Rat   297 TYREPPNPEYQEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDGILLYA-QVLNETIQEGGTRED 360

  Fly   150 GVYDVLKLQ--------------EEDVTDTGFVCAGEGEL-----------------IFTSERPV 183
            |:..|.|:|              :.:..:|.||....|:|                 |:.:.||:
  Rat   361 GLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLESGDFQPAAHYSGAEKQIWWTGRPI 425

  Fly   184 ------------------------------IAWLLLGS--------------------LKALTRM 198
                                          :|.:.||:                    .|.|..|
  Rat   426 PWVKGAPPLDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFRKLMLEKELASM 490

  Fly   199 LYKVDVNIKIEPVE-GDARRY------RYLFSLVKDNSQTMLM----------------GRPTSV 240
            |::    |:.|.:: |::.||      |...|| :.:|...||                |...::
  Rat   491 LWR----IRWEELQFGNSDRYHKGAGSRLTLSL-RGSSYGSLMTAHGKYQIFANTGHFKGNVVAI 550

  Fly   241 SKTIPETVQRSNS-----SNASDLQMNS-----------------SSFCKM-------------F 270
            .....:.::.:..     .:..|:|.|.                 :.:|..             .
  Rat   551 KHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINL 615

  Fly   271 PWHF---IMNEQLELVQLGRGFSKLYKPYMADFG------CQATTYFDFKRPKGLTMKFRD---- 322
            .|.|   ::|:      |.:|.:.|:...::..|      |...:.|..|........||.
  Rat   616 DWMFRYSLIND------LVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEP 674

  Fly   323 ------IVRRTYT-PFLIGLNNPPGAVDFPAIGLEIKGQMVHCPESNSLLFIGSPF-LDGLD--- 376
                  ..::.:| |.|:. .||     .|..|::.............:.....|| |:|||
  Rat   675 DDSHALYAKKLWTAPELLS-GNP-----LPTTGMQKADVYSFAIILQEIALRSGPFYLEGLDLSP 733

  Fly   377 ----GLTCNG---LFISDIPLHDATREVILVGEQARAQD-----------GLRRRMDK------- 416
                ....||   .|...|.......|::|:.|:..|||           |..||.:|
  Rat   734 KEIVQKVRNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNKEGGTSIL 798

  Fly   417 -------------IKNSIEEANSAVTKERKKNVSLLHLIFPAEIAEKLWLGSSIDAKTYPDVTIL 468
                         ::..:||...|..:|::|..:||:.|.|..:||:|..|.::.|:.:..|||.
  Rat   799 DNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIY 863

  Fly   469 FSDIVGFTSICSRATPFMVISMLEGLYKDFDEFCDFFDVYKVETIGDAYCVASGL-HRASIYDAH 532
            ||||||||::.:.:||..|:::|..||..||...|.|||||||||||||.|.||| .|.....|.
  Rat   864 FSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAP 928

  Fly   533 KVAWMALKMIDACS----KHITHDGEQIKMRIGLHTGTVLAGVVGRKMPRYCLFGHSVTIANKFE 593
            ::|.|||.::||.|    :|..||  |:::|||:|||.|.|||||.|||||||||.:|..|::.|
  Rat   929 EIARMALALLDAVSSFRIRHRPHD--QLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRME 991

  Fly   594 SGSEALKINVSPTTKDWLTKHEGFEFELQPRDPSFLPKEFPNPGGTETCYFLESFRNP 651
            |..:||||:||.||||.|.:...|:.||:.      ..|....|...|.:.|...:.|
  Rat   992 SNGQALKIHVSSTTKDALDELGCFQLELRG------DVEMKGKGKMRTYWLLGERKGP 1043

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002	36/203 (18%)
		HNOBA	259..451	CDD:285003	53/283 (19%)
		CYCc	430..619	CDD:214485	98/193 (51%)
		Guanylate_cyc	457..647	CDD:278633	94/194 (48%)
Npr2	NP_446290.1	PBP1_NPR_B	26..421	CDD:380607	26/124 (21%)
		PK_GC-A_B	518..792	CDD:270944	48/286 (17%)
		HNOBA	<798..846	CDD:400168	11/47 (23%)
		CYCc	825..1009	CDD:214485	96/185 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810