DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gycalpha99B and Adcy9

DIOPT Version :9

Sequence 1:	NP_477088.2	Gene:	Gycalpha99B / 43493	FlyBaseID:	FBgn0013972	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	XP_011244107.1	Gene:	Adcy9 / 11515	MGIID:	108450	Length:	1372	Species:	Mus musculus

Alignment Length:	407	Identity:	100/407 - (24%)
Similarity:	172/407 - (42%)	Gaps:	73/407 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 TMLMGRPTSVSKTIPETVQRSNSSNASDLQMNSSSFC--KMFPWHFIMNEQLEL-VQLGRGFSKL 292
            |.|.||..|.:.|:..|...:..|     |:.|.|.|  .:...:.:|...|.| :.||..:|.|
Mouse   196 TPLSGRVDSSNHTLTATPADTCLS-----QVGSFSICIEVLLLLYTVMQLPLYLSLFLGVVYSVL 255

  Fly   293 YKPYMADFGCQATTYFDFKRPKGLTMKFRDIVRRTYTPFLIGLNNPPGAVDFP------------ 345
            ::    .||........:..|                        .|||:.:.
Mouse   256 FE----TFGYHFRNEDCYPSP------------------------GPGALHWELLSRALLHVCIH 292

  Fly   346 AIGLEIKGQMVHCPESNSLLFIGSPFLDGLDGLTCNGLFISDIPLHDATREVILVGEQAR--AQD 408
            |||:.: ..|......::.|.:|...:.|           .|:.:..|.:|.::.....|  |.|
Mouse   293 AIGIHL-FVMSQVRSRSTFLKVGQSIMHG-----------KDLEVEKALKERMIHSVMPRIIADD 345

  Fly   409 GLRRRMDKIKNSIEEANSAVTKERKKNVSLLHLIFPAEIAEKLWLGSSIDAKTYPDVTILFSDIV 473
            .:::..::.:||::...::..|.|||..|    |..|.||.:.:....|:     :|:|||:|||
Mouse   346 LMKQGDEESENSVKRHATSSPKNRKKKSS----IQKAPIAFRPFKMQQIE-----EVSILFADIV 401

  Fly   474 GFTSICSRATPFMVISMLEGLYKDFDEFCDFFDVYKVETIGDAYCVASGLHRASIYDAHKVAWMA 538
            |||.:.:..:...::.:|..|:..||..|:.....|:.|:||.|...:|........|:....|.
Mouse   402 GFTKMSANKSAHALVGLLNDLFGRFDRLCEQTKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMG 466

  Fly   539 LKMIDACSKHITHDGEQIKMRIGLHTGTVLAGVVGRKMPRYCLFGHSVTIANKFESGSEALKINV 603
            |.||.|..:......|.:.||:|:||||||.|::|.:..::.::.:.|.:||..|....|.|:::
Mouse   467 LGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHI 531

  Fly   604 SPTTKDWLTKHEGFEFE 620
            |..|..:|  .:.:|.|
Mouse   532 SEATAKYL--DDRYEME 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002
		HNOBA	259..451	CDD:285003	41/208 (20%)
		CYCc	430..619	CDD:214485	58/188 (31%)
		Guanylate_cyc	457..647	CDD:278633	51/164 (31%)
Adcy9	XP_011244107.1	MFS	<134..260	CDD:391944	19/72 (26%)
		Guanylate_cyc	385..573	CDD:306677	51/169 (30%)
		Guanylate_cyc	1069..1260	CDD:306677
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810