DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gycalpha99B and Adcy7

DIOPT Version :9

Sequence 1:	NP_477088.2	Gene:	Gycalpha99B / 43493	FlyBaseID:	FBgn0013972	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	XP_006530643.1	Gene:	Adcy7 / 11513	MGIID:	102891	Length:	1146	Species:	Mus musculus

Alignment Length:	302	Identity:	77/302 - (25%)
Similarity:	141/302 - (46%)	Gaps:	59/302 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   347 IGLEIKGQMVHCPESNSLLFIGSPFLDGLDGLTCNGLFISDIPLHDATREVILVGEQARAQDGLR 411
            :||::.        :|:::.:|..|         .|.|... .|.||:|::.:...:...   :|
Mouse   178 LGLQLL--------ANAVILLGGNF---------TGAFHKH-QLQDASRDLFIYTVKCIQ---IR 221

  Fly   412 RRMDKIKNSIEEANSAVTKERKKNVSLLHLIFPAEIA--------EKLWLGS-----------SI 457
            |::            .|.|.:::|  ||..:.||.|:        |:|..|.           |:
Mouse   222 RKL------------RVEKRQQEN--LLLSVLPAHISMGMKLAIIERLKEGGDRHYMPDNNFHSL 272

  Fly   458 DAKTYPDVTILFSDIVGFTSICSRATPFMVISMLEGLYKDFDEFCDFFDVYKVETIGDAYCVASG 522
            ..|.:.:|:||::||||||.:.|..:|..::.:|..|:..||:.....:..:::.:||.|...||
Mouse   273 YVKRHQNVSILYADIVGFTRLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSG 337

  Fly   523 LHRASIYDAHKVAWMALKMIDACSKHITHDGEQIKMRIGLHTGTVLAGVVGRKMPRYCLFGHSVT 587
            |..:....|.....|.|.:.:|..:.....|..|.||:|:|:|.||.||:|.:..:|.::.|.|:
Mouse   338 LPVSLPTHARNCVKMGLDICEAIKQVREATGVDISMRVGIHSGNVLCGVIGLRKWQYDVWSHDVS 402

  Fly   588 IANKFESGSEALKINVSPTTKDWLTKHEGFEFE---LQPRDP 626
            :||:.|:.....:::::..|.:.|.|  .:|.|   .:.|||
Mouse   403 LANRMEAAGVPGRVHITEATLNHLDK--AYEVEDGHGEQRDP 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002
		HNOBA	259..451	CDD:285003	22/111 (20%)
		CYCc	430..619	CDD:214485	58/207 (28%)
		Guanylate_cyc	457..647	CDD:278633	52/173 (30%)
Adcy7	XP_006530643.1	AC_N	<75..251	CDD:318454	21/107 (20%)
		Guanylate_cyc	272..422	CDD:306677	44/149 (30%)
		DUF1053	487..593	CDD:399378
		Guanylate_cyc	890..1085	CDD:306677
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900