DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gycalpha99B and ADCY9

DIOPT Version :9

Sequence 1:	NP_477088.2	Gene:	Gycalpha99B / 43493	FlyBaseID:	FBgn0013972	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	XP_005255136.1	Gene:	ADCY9 / 115	HGNCID:	240	Length:	1372	Species:	Homo sapiens

Alignment Length:	464	Identity:	112/464 - (24%)
Similarity:	198/464 - (42%)	Gaps:	83/464 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 VCAGEGELIFTSERPV---IAWLLLGSLKALTRMLYKVDVNIKIE---PVEGDARRYRYLFSLVK 226
            ||.  |..:||..:..   .||..|    |||.:::.:.:..:.:   ||.|..
Human   155 VCV--GFFLFTFTKLYARHYAWTSL----ALTLLVFALTLAAQFQVLTPVSGRG----------- 202

  Fly   227 DNSQTMLMGRPTSVSKTIPETVQRSNSSNASDLQMNSSSFC--KMFPWHFIMNEQLEL-VQLGRG 288
            |:|......|||....:                |:.|.|.|  .:|..:.:|:..|.| :.||..
Human   203 DSSNLTATARPTDTCLS----------------QVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVA 251

  Fly   289 FSKLYKPYMADFGCQATTYFDFKRPKGLTMKFRDIVRRTYTPFLIGLNNPPGAVDFPAIGLEIKG 353
            :|.|::.:...|..:|.    |..|....:.:..:.|        ||.:  |.:....:.|.:..
Human   252 YSVLFETFGYHFRDEAC----FPSPGAGALHWELLSR--------GLLH--GCIHAIGVHLFVMS 302

  Fly   354 QMVHCPESNSLLFIGSPFLDGLDGLTCNGLFISDIPLHDATREVILVGEQAR--AQDGLRRRMDK 416
            |:   ...::.|.:|...:.|           .|:.:..|.:|.::.....|  |.|.:::..::
Human   303 QV---RSRSTFLKVGQSIMHG-----------KDLEVEKALKERMIHSVMPRIIADDLMKQGDEE 353

  Fly   417 IKNSIEEANSAVTKERKKNVSLLHLIFPAEIAEKLWLGSSIDAKTYPDVTILFSDIVGFTSICSR 481
            .:||::...::..|.|||..|    |..|.||.:.:....|:     :|:|||:||||||.:.:.
Human   354 SENSVKRHATSSPKNRKKKSS----IQKAPIAFRPFKMQQIE-----EVSILFADIVGFTKMSAN 409

  Fly   482 ATPFMVISMLEGLYKDFDEFCDFFDVYKVETIGDAYCVASGLHRASIYDAHKVAWMALKMIDACS 546
            .:...::.:|..|:..||..|:.....|:.|:||.|...:|........|:....|.|.||.|..
Human   410 KSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIE 474

  Fly   547 KHITHDGEQIKMRIGLHTGTVLAGVVGRKMPRYCLFGHSVTIANKFESGSEALKINVSPTTKDWL 611
            :......|.:.||:|:||||||.|::|.:..::.::.:.|.:||..|....|.|:::|..|..:|
Human   475 QFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYL 539

  Fly   612 TKHEGFEFE 620
              .:.:|.|
Human   540 --DDRYEME 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002	11/42 (26%)
		HNOBA	259..451	CDD:285003	42/196 (21%)
		CYCc	430..619	CDD:214485	58/188 (31%)
		Guanylate_cyc	457..647	CDD:278633	51/164 (31%)
ADCY9	XP_005255136.1	DUF2339	<118..>301	CDD:287113	40/192 (21%)
		CYCc	326..544	CDD:214485	65/228 (29%)
		Guanylate_cyc	385..573	CDD:278633	51/169 (30%)
		CYCc	1043..1243	CDD:214485
		Guanylate_cyc	1069..1260	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810