DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gycalpha99B and ADCY8

DIOPT Version :9

Sequence 1:	NP_477088.2	Gene:	Gycalpha99B / 43493	FlyBaseID:	FBgn0013972	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	NP_001106.1	Gene:	ADCY8 / 114	HGNCID:	239	Length:	1251	Species:	Homo sapiens

Alignment Length:	322	Identity:	88/322 - (27%)
Similarity:	129/322 - (40%)	Gaps:	73/322 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   382 GLFISDIPLHD-ATREVILVGEQARAQDGLRR------RMDKIKNSI-------EEANSAVTKER 432
            |:|||  .|.| |.|:..|  |..|..:...|      |.:::..|:       |..|.....|.
Human   335 GIFIS--YLSDRAQRQAFL--ETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVED 395

  Fly   433 KKNVSLLHLIFPAEIAEKLWLGSSIDAKTYPDVTILFSDIVGFTSICSRATPFMVISMLEGLYKD 497
            :......|.|:               ...|.:|:|||:|:.|||::.:..:...::.||..|:..
Human   396 EHLQHQFHRIY---------------IHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFAR 445

  Fly   498 FDEFCDFFDVYKVETIGDAYCVASGLHRASIYDAHKVAWMALKMIDACSKHITHDGEQIKMRIGL 562
            ||.........:::.:||.|...|||.......||....|.|.||.......:.....:.||||:
Human   446 FDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGI 510

  Fly   563 HTGTVLAGVVGRKMPRYCLFGHSVTIANKFESGSEALKINVSPTTKD------------------ 609
            |:|:||.||:|.:..::.::...|.||||.|||....:|::|..|.|
Human   511 HSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNE 575

  Fly   610 WLTKHEGFEFEL--QPRD-----PSFLPKEF------PNPGGTETCYFLESFRNPALDSELP 658
            :|.|| ..|..|  ||.|     |..:.||.      .|.|.|    |.|...:|    |||
Human   576 FLRKH-NIETYLIKQPEDSLLSLPEDIVKESVSSSDRRNSGAT----FTEGSWSP----ELP 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002
		HNOBA	259..451	CDD:285003	19/82 (23%)
		CYCc	430..619	CDD:214485	55/206 (27%)
		Guanylate_cyc	457..647	CDD:278633	64/220 (29%)
ADCY8	NP_001106.1	Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000250\|UniProtKB:P40146	1..182
		Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000250\|UniProtKB:P40146	1..109
		Essential for CALM1 interaction. /evidence=ECO:0000250\|UniProtKB:P40146	38..40
		Essential for CALM1 interaction. /evidence=ECO:0000250\|UniProtKB:P40146	49..51
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..92
		AC_N	<161..400	CDD:292831	17/68 (25%)
		CYCc	366..564	CDD:214485	56/212 (26%)
		Guanylate_cyc	405..589	CDD:278633	55/199 (28%)
		DUF1053	617..711	CDD:283888	7/20 (35%)
		CYCc	944..1148	CDD:214485
		Guanylate_cyc	973..1172	CDD:278633
		Involved in CALM1 interaction. /evidence=ECO:0000250\|UniProtKB:P40146	1109..1251
		Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000250\|UniProtKB:P40146	1200..1215
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1223..1251
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810