DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gycalpha99B and ADCY1

DIOPT Version :9

Sequence 1:	NP_477088.2	Gene:	Gycalpha99B / 43493	FlyBaseID:	FBgn0013972	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	NP_066939.1	Gene:	ADCY1 / 107	HGNCID:	232	Length:	1119	Species:	Homo sapiens

Alignment Length:	306	Identity:	87/306 - (28%)
Similarity:	142/306 - (46%)	Gaps:	57/306 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   361 SNSLLFIGSPFLDGLDGLTCNGLFISDIPLHDATREVILVGEQARA--QDGLRRRMDKIKNSIEE 423
            :|:|||:         |:...|:|:. |....:.|:..|   |||:  :|.||         :|:
Human   216 ANALLFV---------GVNMYGVFVR-ILTERSQRKAFL---QARSCIEDRLR---------LED 258

  Fly   424 ANSAVTKERKKNVSLL-----------HLIFPAEIAEKLWLGSSIDAKTYPDVTILFSDIVGFTS 477
            .|.   |:.:..:|||           .|..|..|..|:::      :.:.:|:|||:||||||.
Human   259 ENE---KQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYI------QRHDNVSILFADIVGFTG 314

  Fly   478 ICSRATPFMVISMLEGLYKDFDEFCDFFDVYKVETIGDAYCVASGLHRASIYDAHKVAWMALKMI 542
            :.|:.|...::.:|..|:..|||........:::.:||.|...|||.:.....||....|.|.||
Human   315 LASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMI 379

  Fly   543 DACSKHITHDGEQIKMRIGLHTGTVLAGVVGRKMPRYCLFGHSVTIANKFESGSEALKINVSPTT 607
            |..:.........:.||:|||||.||.||:|.:..:|.::.:.||:||..|:.....|::::.||
Human   380 DTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTT 444

  Fly   608 KDWLTKHEGFEFELQP----RDPSFLPKEFPNPGGTETCYFLESFR 649
            ...|..    ::|::|    ...|||...     ..||.:.:.|.|
Human   445 LACLNG----DYEVEPGYGHERNSFLKTH-----NIETFFIVPSHR 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002
		HNOBA	259..451	CDD:285003	25/102 (25%)
		CYCc	430..619	CDD:214485	60/199 (30%)
		Guanylate_cyc	457..647	CDD:278633	59/193 (31%)
ADCY1	NP_066939.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		AC_N	<161..292	CDD:292831	25/100 (25%)
		CYCc	258..453	CDD:214485	61/207 (29%)
		Guanylate_cyc	294..476	CDD:278633	59/196 (30%)
		Interaction with calmodulin. /evidence=ECO:0000250	493..520
		CYCc	826..1037	CDD:214485
		Guanylate_cyc	859..1056	CDD:278633
		Interaction with calmodulin. /evidence=ECO:0000250	1024..1047
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810