DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gycalpha99B and Adcy3

DIOPT Version :9

Sequence 1:	NP_477088.2	Gene:	Gycalpha99B / 43493	FlyBaseID:	FBgn0013972	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	NP_612178.2	Gene:	Adcy3 / 104111	MGIID:	99675	Length:	1145	Species:	Mus musculus

Alignment Length:	252	Identity:	73/252 - (28%)
Similarity:	130/252 - (51%)	Gaps:	44/252 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   412 RRMDKIKNSIEEANSAVTKERKKNVSLLHLIFPAEIAEKLWLGSSIDAK-------------TYP 463
            |:..::|.::||.:     ::::|:.|  .|.|..:|:::......|..             .:.
Mouse   259 RQSLEVKMNLEEQS-----QQQENLML--SILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHE 316

  Fly   464 DVTILFSDIVGFTSICSRATPFMVISMLEGLYKDFDEFCDFFDVYKVETIGDAYCVASGLHRASI 528
            :|:|||:||||||.:.|..:...::.:|..|:..||:....:...:::.:||.|....||  ...
Mouse   317 NVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGL--PDY 379

  Fly   529 YDAHKVA--WMALKMIDACS--KHITHDGEQIKMRIGLHTGTVLAGVVGRKMPRYCLFGHSVTIA 589
            .:.|.|.  .|.|.|::|.|  :..|..|  :.||:|:||||||.||:|:|..:|.::...||:|
Mouse   380 REDHAVCSILMGLAMVEAISYVREKTKTG--VDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVA 442

  Fly   590 NKFESGSEALKINVSPTTKDWLTKHEGFEFELQPRDPSFLPKEFPNPGGTETCYFLE 646
            ||.|:|....::::|.:|.|.|   :| ||:::|.|           ||:. |.:|:
Mouse   443 NKMEAGGIPGRVHISQSTMDCL---KG-EFDVEPGD-----------GGSR-CDYLD 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002
		HNOBA	259..451	CDD:285003	9/38 (24%)
		CYCc	430..619	CDD:214485	61/205 (30%)
		Guanylate_cyc	457..647	CDD:278633	64/207 (31%)
Adcy3	NP_612178.2	AC_N	<44..303	CDD:318454	10/50 (20%)
		Guanylate_cyc	310..494	CDD:306677	63/194 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	504..564
		Guanylate_cyc	915..1122	CDD:306677
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810