DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gycalpha99B and Adcy4

DIOPT Version :9

Sequence 1:	NP_477088.2	Gene:	Gycalpha99B / 43493	FlyBaseID:	FBgn0013972	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	NP_001348533.1	Gene:	Adcy4 / 104110	MGIID:	99674	Length:	1077	Species:	Mus musculus

Alignment Length:	435	Identity:	103/435 - (23%)
Similarity:	171/435 - (39%)	Gaps:	96/435 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 IPETVQRSNSSNASDLQMNSSSFCKMFPWHFIM-----NEQLE-------------LVQLGRGFS 290
            :|.....|.....||....::..|.:..:..::     .:||:             |:.||.||
Mouse    44 LPAVAWASGRELTSDPSFLTTVLCALGGFSLLLGLASREQQLQRWTRPLSGLIWVALLALGYGF- 107

  Fly   291 KLYKPYMADFGCQATTYFDFKRPKGLTMKFRDIVRRTYTPFLIGLNNPPGAVDFPA--------- 346
             |:...:.....| .::|.|            |:...|....:|:.:...|....:
Mouse   108 -LFTGGVVSAWDQ-VSFFLF------------IIFTVYAMLPLGMRDAAAAGVISSLSHLLVLGL 158

  Fly   347 -IGLEIKGQMVHCPE--SNSLLFIGSPFLDGLDGLTCNGLFISDIPLHDATREVILVGEQARAQD 408
             :|.:.:.|....|:  :|::||:            |..:..:   .|.|..|..|......|..
Mouse   159 YLGWQPESQRALLPQLAANAVLFL------------CGNVVGA---YHKALMERALRATFREALS 208

  Fly   409 GL--RRRMDKIKNSIEEANSAVTKERKKNVSLLHLIFP--------AEIAEKLWLGS-------- 455
            .|  |||:|              .|:|....||..|.|        |||..:|..|.
Mouse   209 SLHSRRRLD--------------TEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQRSRPENTN 259

  Fly   456 ---SIDAKTYPDVTILFSDIVGFTSICSRATPFMVISMLEGLYKDFDEFCDFFDVYKVETIGDAY 517
               |:..|.:..|::|::||||||.:.|..:|..::.||..|:..||:.....:..:::.:||.|
Mouse   260 NFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKILGDCY 324

  Fly   518 CVASGLHRASIYDAHKVAWMALKMIDACSKHITHDGEQIKMRIGLHTGTVLAGVVGRKMPRYCLF 582
            ...|||..:....|.....|.|.|..|..|.....|..|.||:|:|:|:||.||:|.:..:|.::
Mouse   325 YCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRVATGVDINMRVGVHSGSVLCGVIGLQKWQYDVW 389

  Fly   583 GHSVTIANKFESGSEALKINVSPTTKDWLTKHEGFE-FELQPRDP 626
            .|.||:||..|:|....:::::..|...|......| .:.:.|||
Mouse   390 SHDVTLANHMEAGGVPGRVHITGATLALLAGAYAVERADTEHRDP 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002
		HNOBA	259..451	CDD:285003	42/231 (18%)
		CYCc	430..619	CDD:214485	63/208 (30%)
		Guanylate_cyc	457..647	CDD:278633	54/171 (32%)
Adcy4	NP_001348533.1	AC_N	<115..246	CDD:318454	33/172 (19%)
		Guanylate_cyc	264..418	CDD:306677	49/153 (32%)
		DUF1053	479..580	CDD:368844
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	502..524
		Guanylate_cyc	866..1065	CDD:306677
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810