DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gycalpha99B and adcy1

DIOPT Version :9

Sequence 1:	NP_477088.2	Gene:	Gycalpha99B / 43493	FlyBaseID:	FBgn0013972	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	XP_002933461.1	Gene:	adcy1 / 100492373	XenbaseID:	XB-GENE-950909	Length:	1122	Species:	Xenopus tropicalis

Alignment Length:	303	Identity:	82/303 - (27%)
Similarity:	142/303 - (46%)	Gaps:	53/303 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   362 NSLLFIGSPFLDGLDGLTCNGLFISDIPLHDATREVILVGEQARAQDGLRRRMDKIKNSIEEANS 426
            |::||:         .:..:|:|:.            ::.|:|:     |:...:.:|.||: ..
Frog   207 NAILFV---------SVNLSGVFVR------------ILTERAQ-----RKAFLQARNCIED-RL 244

  Fly   427 AVTKERKKNVSLLHLIFPAEIA-----------EKLWLGSSIDAKTYPDVTILFSDIVGFTSICS 480
            .:..|.:|...||..:.|..:|           |:::  ..|..:.:.:|:|||:|||||||:.|
Frog   245 RLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIF--HKIYIQRHDNVSILFADIVGFTSLAS 307

  Fly   481 RATPFMVISMLEGLYKDFDEFCDFFDVYKVETIGDAYCVASGLHRASIYDAHKVAWMALKMIDAC 545
            :.|...::.:|..|:..|||........:::.:||.|...|||.:.....||....|.|.|||..
Frog   308 QCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTI 372

  Fly   546 SKHITHDGEQIKMRIGLHTGTVLAGVVGRKMPRYCLFGHSVTIANKFESGSEALKINVSPTTKDW 610
            :.........:.||:|||||.||.||:|.:..:|.::.:.||:||..|:|....|::::..|.:.
Frog   373 TSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAGGLPGKVHITKNTLEC 437

  Fly   611 LTKHEGFEFELQP----RDPSFLPKEFPNPGGTETCYFLESFR 649
            |..    ::|::|    ...|||.|.     ..||.:.:.|.|
Frog   438 LNG----DYEVEPGYGHERNSFLKKH-----NIETFFIVPSHR 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002
		HNOBA	259..451	CDD:285003	18/99 (18%)
		CYCc	430..619	CDD:214485	61/199 (31%)
		Guanylate_cyc	457..647	CDD:278633	62/193 (32%)
adcy1	XP_002933461.1	AC_N	<37..282	CDD:292831	18/103 (17%)
		CYCc	248..443	CDD:214485	61/200 (31%)
		Guanylate_cyc	284..466	CDD:278633	62/190 (33%)
		CYCc	817..1028	CDD:214485
		Guanylate_cyc	850..1047	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910