Protein Alignment Gycalpha99B and gucy1b1

DIOPT Version :10

• Sequence 1: NP_477088.2
• Gene: Gycalpha99B / 43493
• FlyBaseID: FBgn0013972
• Length: 676
• Species: Drosophila melanogaster
• Sequence 2: XP_004911214.1
• Gene: gucy1b1 / 100379900
• XenbaseID: XB-GENE-950986
• Length: 618
• Species: Xenopus tropicalis
• Alignment Length: 605
• Identity: 178/605 - (29%)
• Similarity: 311/605 - (51%)
• Gaps: 56/605 - (9%)

  Fly    58 LNTAVTSLVAKY--RQNWPNIHK-LKLDPQ-------TFKSCANYDYLADIQELLLKMDEASASE 112
            :|.|:..||.:.  .:.|.:|.| .:||.:       .:.....||.::...::|    ..:|.:
 Frog     5 VNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVSAATKVL----NLNAGD 65

  Fly   113 ILVLLGEELITCCCTGIIERAFRCLGTDLQEFLGSLDGVYDVLKLQEEDVTDTGFVCA----GEG 173
            ||.:.|......|.....:...|.||::::|||.:||.::|.|......:....|.|.    |:|
 Frog    66 ILQMFGNMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLGTIYPGMRAPSFRCTDAEKGKG 130

  Fly   174 ELI-FTSERPVIAWLLLGSLKALTRMLYKVDVNIKIEPVEGDARRYRYLFSLVKDNSQTMLMGRP 237
            .:: :.|||..:..:::|.:|.:.:.::..::::|:.....:.          .|::|.::..:.
 Frog   131 LILHYYSEREGLQDIVIGIVKTVAQQIHGTEIDMKVIQQRNEE----------CDHTQFLIEEKD 185

  Fly   238 TSVSKTIPETVQRSNSSNASDLQMNSSSFCKMFPWHFIMNEQLELVQLGRGFSKLYKPYMADFGC 302
            |. .:...|...|...:...:.:::..:|||.||:|.:.:..|.:.|.|....::. |.:....|
 Frog   186 TR-EEDFYEDQDRFEENGTQESRISPYTFCKAFPFHIMFDRDLFVTQCGNAIYRVL-PQLQPGNC 248

  Fly   303 QATTYFDFKRPKGLTMKFRDIVRRTYTPFLIGLNNPPGAVDF-------PAIGLEI-----KGQM 355
            ...:.|...||. :.:.|..|:....|.|:  |.:..|.:|.       ...|.||     ||||
 Frog   249 NLLSVFSLVRPH-IDISFHGILSHINTVFV--LRSKEGLLDVEKSESEDELTGTEISCLRLKGQM 310

  Fly   356 VHCPESNSLLFIGSPFLDGLDGLTCNGLFISDIPLHDATREVILVGEQARAQDGLRRRMDKIKNS 420
            ::.||::::||:.||.:..||.||..||::||||||||||:::|:|||.|.:..|.:.::.:.:.
 Frog   311 IYLPEADNILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDR 375

  Fly   421 IEEANSAVTKERKKNVSLLHLIFPAEIAEKLWLGSSIDAKTYPDVTILFSDIVGFTSICSRAT-- 483
            ::....|:..|:||..:||:.:.|..:|.:|.....:.||.|.:||||||.||||.:.||:..
 Frog   376 LQHTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNTFCSKHASG 440

  Fly   484 --PFMVISMLEGLYKDFDEFCDFFD---VYKVETIGDAYCVASGLHRASIYDAHKVAWMALKMID 543
              ...::::|..:|..||...|..:   ||||||:||.|...||:....::.|..:..:||.|::
 Frog   441 EGAMKIVNLLNDIYTRFDILTDSRNNPYVYKVETVGDKYMTVSGIPEPCVHHARSICHLALDMME 505

  Fly   544 ACSKHITHDGEQIKMRIGLHTGTVLAGVVGRKMPRYCLFGHSVTIANKFESGSEALKINVSPTTK 608
            ...: :..|||.:::.||:|||.|:.||:|::||||||||::|.:.::.|:..|..|||||..|.
 Frog   506 IAGQ-VQVDGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTY 569

  Fly   609 DWLTKHEGF--EFELQPRDP 626
            ..|...|..  :|.||.|.|
 Frog   570 RCLMSPENSDPQFHLQYRGP 589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	<109..208	CDD:462233	24/103 (23%)
		HNOBA	259..451	CDD:462234	64/203 (32%)
		Guanylate_cyc	457..647	CDD:425528	71/179 (40%)
gucy1b1	XP_004911214.1	HNOB	2..166	CDD:462233	36/164 (22%)
		HNOBA	207..406	CDD:462234	64/202 (32%)
		Guanylate_cyc	412..605	CDD:425528	71/179 (40%)