DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gycalpha99B and gucy1a2

DIOPT Version :9

Sequence 1:	NP_477088.2	Gene:	Gycalpha99B / 43493	FlyBaseID:	FBgn0013972	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	XP_009290254.2	Gene:	gucy1a2 / 100330875	ZFINID:	ZDB-GENE-121023-3	Length:	608	Species:	Danio rerio

Alignment Length:	583	Identity:	232/583 - (39%)
Similarity:	334/583 - (57%)	Gaps:	81/583 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 GEELITCCCTGIIERAFRCLGTDLQEFLGSLDGVYDVLKLQEEDVTDTG---------FVC---- 169
            |||....|... .||..|.||.:||:|....|.:.:.::      |..|         |:|
Zfish    20 GEEFFGLCLEE-NERVLRALGGNLQDFFNGFDALLEHIR------TSCGRRASSEAPSFLCKDAP 77

  Fly   170 ---------AGEGELIFT---SERPVIAWLLLGSLKALTRMLYKVDVNIKIEP--------VEGD 214
                     :|.|..:..   :..|.:...:.|.::|..|.:|:.:|:::..|        .:|:
Zfish    78 QENEETNAESGAGRTLILHCFNPDPTVGVAMPGLIRAAARRIYQSEVSVEEAPPTWLHTANEDGE 142

  Fly   215 ARRYRYLFSLVKDNSQTMLMGRPTSVS-----------KTIPETVQRSNSSNAS--DLQMNSSSF 266
                     |..|:|.:.....|:|.:           .|.|.:..||...:.|  ||::..|:|
Zfish   143 ---------LSADSSPSSSPSPPSSSAPACLSFLIREVHTPPTSSSRSRQLSRSPLDLRIGLSTF 198

  Fly   267 CKMFPWHFIMNEQLELVQLGRGFSKLYK--PYMADFGCQATTY---FDFKRPKGLTMKFRDIVRR 326
            |:.||:|.::...:|::|:|.|..|..|  |:      :..|:   |:...|: :...|::|:.|
Zfish   199 CRAFPFHLVLGSNMEVLQVGEGLRKQAKTDPH------RTLTFSNSFELVSPR-IPCSFQNILLR 256

  Fly   327 TYTPFLIGLNNPPGAVDFPAIGLEIKGQMVHCPESNSLLFIGSPFLDGLDGLTCNGLFISDIPLH 391
            ..|||.|.......::|.....:|:||||:|.|||||::|:|||.:|.|:.|...||.:||||:|
Zfish   257 LSTPFTIRTRPDGSSLDCREKVMELKGQMLHLPESNSIMFLGSPRVDRLEELMGRGLHLSDIPIH 321

  Fly   392 DATREVILVGEQARAQDGLRRRMDKIKNSIEEANSAVTKERKKNVSLLHLIFPAEIAEKLWLGSS 456
            ||||:||||||||:|||||::||||:|.::|:.:.|:.:|:::.|.||:.|||.::|::||.|..
Zfish   322 DATRDVILVGEQAKAQDGLKKRMDKLKATLEKTHQALEEEKRRTVDLLYSIFPGDVAQRLWQGLP 386

  Fly   457 IDAKTYPDVTILFSDIVGFTSICSRATPFMVISMLEGLYKDFDEFCDFFDVYKVETIGDAYCVAS 521
            :.||.:.|||:|||||||||::|::.||..|||||..||..||..|...||||:||||||||||.
Zfish   387 VQAKKFDDVTMLFSDIVGFTAVCAQCTPMQVISMLNELYTRFDYQCGILDVYKIETIGDAYCVAG 451

  Fly   522 GLHRASIYDAHKVAWMALKMIDACSKHITHDGEQIKMRIGLHTGTVLAGVVGRKMPRYCLFGHSV 586
            ||||.....|..:|.|||||::...:.:|.||:.||:|||:|:|:|||||||..||||||||::|
Zfish   452 GLHRKIDSHAKPIALMALKMMELSEEVLTPDGKPIKLRIGIHSGSVLAGVVGVMMPRYCLFGNNV 516

  Fly   587 TIANKFESGSEALKINVSPTTKDWLTKHEGFEFELQPRDPSFLPKEFPN--PGGTETCYFLES 647
            |:|:||||||....|||||||...|.....|.|  .||....||..||.  ||   .|||||:
Zfish   517 TLASKFESGSHPRCINVSPTTYQLLRDDRSFTF--IPRSRQELPDNFPKEIPG---ICYFLEA 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002	25/114 (22%)
		HNOBA	259..451	CDD:285003	82/196 (42%)
		CYCc	430..619	CDD:214485	106/188 (56%)
		Guanylate_cyc	457..647	CDD:278633	108/191 (57%)
gucy1a2	XP_009290254.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	201	1.000	Domainoid score	I2965
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	382	1.000	Inparanoid score	I2009
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	1	1.000	-	-		FOG0008257
OrthoInspector	1	1.000	-	-		otm25393
orthoMCL	1	0.900	-	-		OOG6_106420
Panther	1	1.100	-	-	O	PTHR45655
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4585
SonicParanoid	1	1.000	-	-		X3073
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.860