Protein Alignment Gycalpha99B and gucy1b1

DIOPT Version :9

• Sequence 1: NP_477088.2
• Gene: Gycalpha99B / 43493
• FlyBaseID: FBgn0013972
• Length: 676
• Species: Drosophila melanogaster
• Sequence 2: NP_001238874.1
• Gene: gucy1b1 / 100150304
• ZFINID: ZDB-GENE-090313-160
• Length: 608
• Species: Danio rerio
• Alignment Length: 606
• Identity: 183/606 - (30%)
• Similarity: 308/606 - (50%)
• Gaps: 58/606 - (9%)

  Fly    58 LNTAVTSLVAKYRQNWPNI-HKLKLDPQT-----------FKSCANYDYLADIQELLLKMDEASA 110
            :|.|:..||  .|...|:: ..:|.:.|.           ::....||.:|...: :||||   |
Zfish     5 VNHALELLV--LRNYGPDVWEDIKREAQVDVEGQFLVRIIYEDAKTYDLVAAASK-VLKMD---A 63

  Fly   111 SEILVLLGEELITCCCTGIIERAFRCLGTDLQEFLGSLDGVYDVLKLQEEDVTDTGFVC--AGEG 173
            ..||.:.|:.....|.....:...|.||::::|||.:||.::|.|......:....|.|  |.:|
Zfish    64 GGILQMFGKMFFEFCQESGYDTILRVLGSNVREFLQNLDALHDHLGTIYPGMRAPSFRCTDAEKG 128

  Fly   174 E---LIFTSERPVIAWLLLGSLKALTRMLYKVDVNIK-IEPVEGDARRYRYLFSLVKDNSQTMLM 234
            .   |.:.|||..:..:::|.:|.:.:.::..::.:| |:|...:....::|.. .||:.:
Zfish   129 NNLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIEMKVIQPKSEECDHIKFLIE-EKDSEE---- 188

  Fly   235 GRPTSVSKTIPETVQRSNSSNASDLQMNSSSFCKMFPWHFIMNEQLELVQLGRGFSKLYKPYMAD 299
                   :...|.:.....:...:.:::..:|||.||:|.:.::.|.|.|.|....::. |.:..
Zfish   189 -------EAFYEDLDGFEENGTQETRISPYTFCKAFPFHLMFDKDLMLTQCGNAIFRVL-PQLQP 245

  Fly   300 FGCQATTYFDFKRPKGLTMKFRDIVRRTYTPFLI----GLNNPPGAVDFPAI-GLEI-----KGQ 354
            ..|..::.|...||. :...|..|:....|.|::    ||.|...|.:...: |.||     |||
Zfish   246 GVCNLSSVFSLVRPH-IDFSFHGILSHINTVFVLRSKEGLLNVETAENEDELTGTEISCLRLKGQ 309

  Fly   355 MVHCPESNSLLFIGSPFLDGLDGLTCNGLFISDIPLHDATREVILVGEQARAQDGLRRRMDKIKN 419
            |:..||:.::||:.||.:..||.||..||::||||||||||:::|:|||.|.:..|.:.::.:.:
Zfish   310 MISLPETENILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTD 374

  Fly   420 SIEEANSAVTKERKKNVSLLHLIFPAEIAEKLWLGSSIDAKTYPDVTILFSDIVGFTSICSRAT- 483
            .::....|:..|:||...||:.:.|..:|.:|.....:.||.|.:||||||.||||.:.||:..
Zfish   375 RLQHTLRALEDEKKKTDRLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHAS 439

  Fly   484 ---PFMVISMLEGLYKDFDEFCDFFD---VYKVETIGDAYCVASGLHRASIYDAHKVAWMALKMI 542
               ...::::|..:|..||...|...   ||||||:||.|...|||.....:.|..:..:||.|:
Zfish   440 AEGAIKIVNLLNDIYTRFDILTDSRKNPYVYKVETVGDKYMTVSGLPEPCTHHAKSICHLALDMM 504

  Fly   543 DACSKHITHDGEQIKMRIGLHTGTVLAGVVGRKMPRYCLFGHSVTIANKFESGSEALKINVSPTT 607
            :...: :..|.:.:::.||:|||.|:.||:|::||||||||::|.:.::.|:..|..|||||..|
Zfish   505 EIAGQ-VKVDEDPVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYT 568

  Fly   608 KDWLTKHEGF--EFELQPRDP 626
            ...|...|..  :|.|:.|.|
Zfish   569 YRCLQSVENADPQFHLEYRGP 589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002	35/149 (23%)
		HNOBA	259..451	CDD:285003	66/201 (33%)
		CYCc	430..619	CDD:214485	73/197 (37%)
		Guanylate_cyc	457..647	CDD:278633	69/179 (39%)
gucy1b1	NP_001238874.1	HNOB	2..166	CDD:285002	40/166 (24%)
		HNOBA	207..406	CDD:285003	66/200 (33%)
		CYCc	385..584	CDD:214485	74/199 (37%)
		Guanylate_cyc	412..605	CDD:278633	69/179 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820