Protein Alignment Gycalpha99B and adcy8

DIOPT Version :10

• Sequence 1: NP_477088.2
• Gene: Gycalpha99B / 43493
• FlyBaseID: FBgn0013972
• Length: 676
• Species: Drosophila melanogaster
• Sequence 2: NP_001137224.1
• Gene: adcy8 / 100148976
• ZFINID: ZDB-GENE-070912-197
• Length: 1225
• Species: Danio rerio
• Alignment Length: 840
• Identity: 170/840 - (20%)
• Similarity: 279/840 - (33%)
• Gaps: 300/840 - (35%)

  Fly    28 LEDEELSDDALTLTHLQ--MAIQLLTAPSNEDLNTAVTSLVAKYRQNWPNIHKLKLDPQTFKSCA 90
            ||.|....:.|.|:.|.  :.::::...:|.:..|........|...:.|:..|..|.:.|   .
Zfish   337 LETENQRQERLVLSVLPRFVVLEMINDMTNVEDETLQHQFHRIYIHRYENVSILFADVKGF---T 398

  Fly    91 NYDYLADIQELLLKMDEASA----------SEILVLLGEELITC--CCTGIIE----RAFRCLGT 139
            |.......|||:..::|..|          ...:.:||:    |  |.:|:.|    .|..|
Zfish   399 NLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGD----CYYCVSGLPEPRPDHAHCC--- 456

  Fly   140 DLQEFLGSLDGVYDVLKLQEEDV-----TDTGFVCAGEGELIFTSERPVIAWLLLGSLK-ALTRM 198
             ::..|..:..:..|....:.|:     ..:|.|..|                :||..| .....
Zfish   457 -VEMGLSMIKTIRYVRSRTKHDIDMRIGIHSGSVLCG----------------VLGLRKWQFDVW 504

  Fly   199 LYKVDVNIKIE----------------------PVEGDARRYRYLFSLVKDNSQTMLMGRPTSVS 241
            .:.||:..|:|                      .||....:.|..| |.:.|.:|.|:.:|....
Zfish   505 SWDVDIANKLESGGIPGRIHISKAALDCLNGDYEVEEGHGKDRNDF-LRRHNIETFLIKQPEESL 568

  Fly   242 KTIPETVQRSNSSNASDLQMNSSSFCK-----MFPWHFIMNEQLELVQLG--------------- 286
            .|:||.:.| :|:|.||.:.:::||.:     ..|:|.|:.:|..|..|.
Zfish   569 LTLPEDIMR-DSTNQSDHRTSNTSFTEGTWSPELPFHNIVGKQNTLAALTRHSINLLPNHLAQAL 632

  Fly   287 -------------------RGFSKLYKPYMADF-------------------------------- 300
                               |...||.:.:::.|
Zfish   633 HVRAGSQEINARMQSTIALRSGDKLRQEHISPFSLTFREALLEHKYSQMRDEVFKSNLVCAFIVL 697

  Fly   301 ----GCQA---------------------------TTYFDFKRPKGLTMKFRDIVRRTYTP---- 330
                |.|:                           ||..|:|....:..|....|..||..
Zfish   698 FFITGIQSLLPSARMVTMLIQFSVLILLHCCLVVVTTAEDYKCLPLVLRKACCWVNETYAARNVV 762

  Fly   331 -FLIGLNNPPGAV------DFPAIGLEIKGQ-------------------------MVHCP---E 360
             ||..|.|...|:      ||...| ..:.|                         ||.|.   .
Zfish   763 IFLSILINFLAAMINILWCDFDKSG-SFRNQTFNASASIPDICFYPEYFVFTGVLAMVTCAVFLR 826

  Fly   361 SNSLLFIG-----------------SPFLDGLDGLTCN----------------GLFISDIPLHD 392
            .||:|.:.                 :|.....|.||.|                .:|:..:..|
Zfish   827 LNSVLKLAILLIMIAIYAVLTEAFYTPLFIRYDTLTLNQSKSFLGTKETSLLLMAMFLLAVFYH- 890

  Fly   393 ATREVILVGEQ----ARAQDGLRRRMDKIKNSIEEANSAVTKERKKNVSLLHLIFPAEIA----E 449
                    |:|    ||. |.|.|...|     ||.|. :.:.|:.|.::|..|.|:.:|    |
Zfish   891 --------GQQLEYTARL-DFLWRVQAK-----EEINE-MRELREHNENMLRNILPSHVARHFLE 940

  Fly   450 KLWLGSSIDAKTYPDVTILFSDIVGFTSICSRA----TPFMVISMLEGLYKDFDEFCD---FFDV 507
            |......:.:::|..|.::|:.|.||....|:.    .....:.:|..:..||||...   |.|:
Zfish   941 KDRDNEELYSQSYDTVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEERFQDI 1005

  Fly   508 YKVETIGDAYCVASGL------------HRASIYDAHKVAWMALKMIDACSKHITHDGEQIKMRI 560
            .|::|||..|...|||            |..::.|      .|:.:.::..:...|.....::||
Zfish  1006 EKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALAD------FAIALNESIQEINKHSFNNFQLRI 1064

  Fly   561 GLHTGTVLAGVVGRKMPRYCLFGHSVTIANKFESGSEALKINVSPTTKDWLTKHEGFEFE 620
            |:..|:|:|||:|.|.|:|.::|.:|.:|::.:|...:.||.:...|...|.: .||.||
Zfish  1065 GMAHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGKIQLPEETYAILNE-RGFAFE 1123

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gycalpha99B	NP_477088.2	HNOB	<109..208	CDD:462233	20/120 (17%)
		HNOBA	259..451	CDD:462234	62/373 (17%)
		Guanylate_cyc	457..647	CDD:425528	50/183 (27%)
adcy8	NP_001137224.1	AcyC	189..541	CDD:441717	41/230 (18%)
		Guanylate_cyc	379..563	CDD:425528	40/211 (19%)
		Adcy_cons_dom	592..686	CDD:461877	11/93 (12%)
		Guanylate_cyc	948..1147	CDD:425528	50/183 (27%)