DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cap-D2 and YCS4

DIOPT Version :9

Sequence 1:	NP_651709.1	Gene:	Cap-D2 / 43491	FlyBaseID:	FBgn0039680	Length:	1380	Species:	Drosophila melanogaster
Sequence 2:	NP_013374.1	Gene:	YCS4 / 850977	SGDID:	S000004262	Length:	1176	Species:	Saccharomyces cerevisiae

Alignment Length:	1290	Identity:	296/1290 - (22%)
Similarity:	544/1290 - (42%)	Gaps:	242/1290 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 ASAQNLMRSFDLL----YLTVEKLFQDLQPLLTASEPMSNQQRNSYLNLTKMTLFLQVS------ 129
            ||..:|....||.    :|| .||...|..|:::|  :||..::...||:....|.::.
Yeast    47 ASPDSLEALIDLCHDFPHLT-PKLQTQLSYLISSS--LSNLSKDIKANLSSNVNFTEIGGLIPQW 108

  Fly   130 ---------TVKKINNSVQQAM-----RDQQLNVQKKRAK-PSEGLEQFPNWEVKRGKFLVQLFN 179
                     .::.:...:|..:     :...||...|.:| .|..:|.|.....:....|..:..
Yeast   109 KRHLEEYGYLIQVLLTFLQDELHKVSSQSTNLNRSAKNSKNDSANVELFKRDCNQMENLLESITK 173

  Fly   180 VLQCPLEKLWSPPVAEEDFINLLCDPCYRTIELLPL-RMDNKHVFDTIFQILGTSIKRFNQAMTF 243
            :|:..|.|::.....::.||.|...|.:..:|:.|: ::.:..:|  |.:||...:|...|:.:.
Yeast   174 LLEINLSKIFQTTPEKDLFIGLFTRPLFVLLEIEPVTKVSSLKMF--IQRILAMCVKNHGQSSSI 236

  Fly   244 PVRILQILRGTEHAAHSVAAGILLLHEEYGISSVFSILIKSIVDALRMDSSDSSVSKHFSNFLAE 308
            ...::..|....|.:...|..:.||::||....:...::|.|...: .::.|::..|..||||.:
Yeast   237 QSSLMTNLTYFLHLSVFNAELLKLLNDEYNYPQLTEDILKEISTRV-FNAKDTTGPKAISNFLIK 300

  Fly   309 FSNIAPSLIVPHLEKLAEDLLDCQSHTLRNCVLQIIGDTVVSELTSE-DLSEELKEVRNEFLEHL 372
            .|.::|.:::..: .|...||:..|.|||..|::..|: :|:||..: ...|..|:.....:|.|
Yeast   301 LSELSPGIMLRQM-NLVITLLNNSSITLRCSVVEACGN-IVAELAQDPQTMEHYKQQIAVLIELL 363

  Fly   373 MAHILDISAHVRSKVL----------SIWHHLKTQHAIPLNFLTRVLEEAIGRLEDKSSLVRRAA 427
            .....|.:.:||:|.:          |.::..|          .:....|:..|:|:||||||.:
Yeast   364 EERFQDSNPYVRTKAIQGCSKICDLSSKFNKSK----------AKFTSLAVRSLQDRSSLVRRNS 418

  Fly   428 MHLIKSALESNPY----SSKLSIDELRAKHEHEVQAMEKLNEVLEEERKQEEKLNDEFSSLAPEL 488
            :.|:...|..:|:    .|:|.:.|.   .|:...:..:||..|::...| |.|||.
Yeast   419 VKLLSKLLLKHPFKAIHGSQLRLSEW---EEYLKGSESQLNSTLKKVESQ-ETLNDT-------- 471

  Fly   489 LPFIEENLTEFPDMQFDKEESDE----TLMERIIPLMREKNYKDVIVLVRKVDFLAGNQNMSSLL 549
               ||.:|.|      ::.|.||    |.:|                         |:.|.|:.|
Yeast   472 ---IERSLIE------EEVEQDEGQCRTELE-------------------------GSFNKSAEL 502

  Fly   550 KHEEHCVYVLALLKTYHLLAAGFKQSSEEMLQQIK-TVQFLKDSIDFAVLMTSAFPKLHEMLMSK 613
            ...|:.|             .....::..:|.::| .:.:.||:|.|...:..:...:..:|.||
Yeast   503 SRIENEV-------------ENINATNTSVLMKLKLMIVYYKDAISFIKEIHKSIELISNLLFSK 554

  Fly   614 TNTDVFEAVDLFTTGYMFGIHGTESGMQRMLQLVW-SSDKEKRDAVS----DAYKRVLFSTD--- 670
            ...:|.|::|.......|.|..:|.|:::||.||| ....::..::|    :.||::..:..
Yeast   555 NRNEVLESMDFLVLADAFDIELSEFGIKKMLHLVWMKGTNDEGTSISVHLIECYKQLFLTAPDSC 619

  Fly   671 --QTGRAHAIKVVQNLSKFLSEIEYGHYTALESLMTEWVLGGDIDAAVIQVLFERFTLKLEGTTS 733
              |...||..|.:.|||...|..:......|..:|.|..|   ||..||.:|:..:....:.:..
Yeast   620 NMQEKAAHIAKNLINLSIGASIADLASLEQLLGMMYEQKL---IDQHVINILWAIYNSASKASMQ 681

  Fly   734 NESRL----------------SLQLLIMASQSKSSIVSANTAIIEDIAVGERVRRDPRIFT-SCL 781
            .|..:                |:.:|.|.|.:.:.|.......:.:|.:|....:|..:.. |||
Yeast   682 KEQNVNNRDSEKGFSKEQIHGSIIILGMLSLADNEIALKGLESLLNIGLGAVGLKDLTLCRYSCL 746

  Fly   782 QLLVNSIDANNTAKYYKRQNSDAEFVG--KITRLFLDFFFHRSLYDFDALAMSVFEYFYRMCQAP 844
            .|  ..:....:....|..|.:.|.|.  |:..:.:::......|.....|:|.   .:.:...|
Yeast   747 AL--ERMVPKRSTIITKAINQELEDVAVKKLYAIIINYTKDNEYYPMCEQALSA---LFTISSKP 806

  Fly   845 DVIAQQLVTALLKQFNESWLVKEAAAIVPSPDKADTETVPDSQPLEIPHSQTLTPTQTQADSQSQ 909
            |::|..|:.            ::.......|::.|:               .|:..|:..
Yeast   807 DILATDLIR------------EKTMMTFGKPEEEDS---------------ILSLEQSSR----- 839

  Fly   910 MQGTLIPVYLVSRLIFCIGYMTIKEMIFLDMDIYNNMKYRDELTALEERKNRNQQAGSSHNAARL 974
                   |..:|:|:|.:|.:.||.:::|:             ....|.|.|..:|.:.:.
Yeast   840 -------VVSLSQLLFIVGQVAIKTLVYLE-------------KCEAEFKKRKIEAETRNG---- 880

  Fly   975 TLNMSAMEVRKRLSGVAAEPQQEPDD---DLVGATAEDNIAEEIHGICEDMLLYNPDALLSKLAP 1036
                   :|:.:.:.|....|....|   :::|.|.||:..:.|..:.|:.||:...::|.|..|
Yeast   881 -------KVKNQGADVTNTTQDNGGDKELEMIGGTNEDDFTDAIQFVKENELLFGEKSILGKFCP 938

  Fly  1037 FIIEICKRPGEFGDPTLQQAATLALARLMTVSSRFCESNMSFLMNILNLTKNIRIKCNTVVGLSD 1101
            .:.||......|.||.||:.|||.|.:||.:||::||.::..|:.::..:.:..|:.|.|:||.|
Yeast   939 IVEEIVSNSSRFSDPMLQRTATLCLEKLMCLSSKYCEKSLPLLITVMEKSPDPTIRSNAVLGLGD 1003

  Fly  1102 LTFRFPNIIEPWTGHFYAQLHESNTELRLTAVKMLSHLILNEMIRVKGQIADMALCIVDGNEEIR 1166
            :...|.|:::..|.:.|.:||:.|..::.|.:..::.|||...::||||:.:||.|:.:.::.|.
Yeast  1004 MAVCFNNLVDENTDYLYRRLHDENLMVQRTCLMTVTFLILAGQVKVKGQLGEMAKCLDNPDQGIS 1068

  Fly  1167 NITKQFFKEIANKSNILYNVLPDIISRLGDINLNLDEDKYRIIMSYILGLIQKDRQIETLVEKLC 1231
            ::.:.||.|:|:|.|.:||...||.|.|...:| |.::.::.|:.::|..|.|:|..:.|.|||.
Yeast  1069 DMCRLFFTELASKDNAIYNGFIDIFSNLSSDDL-LGKESFKKIIKFLLTFIDKERHQKQLNEKLV 1132

  Fly  1232 LRFPVTRVERQWRDIAYCLGLLTYNERAVKKLMDNMQHYRDKVQVDEVYQSFKLI 1286
            .|......::||.|||:.|..|.|....|..|::               |.||::
Yeast  1133 GRLRKCETQKQWDDIAFVLNNLPYKNEDVTALLE---------------QGFKVV 1172

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cap-D2	NP_651709.1	Cnd1_N	77..243	CDD:289674	39/191 (20%)
		COG5098	85..1269	CDD:227429	290/1261 (23%)
		Cnd1	1091..1254	CDD:289487	55/162 (34%)
YCS4	NP_013374.1	COG5098	1..1171	CDD:227429	295/1287 (23%)
		HEAT repeat	313..342	CDD:293787	10/30 (33%)
		HEAT repeat	351..384	CDD:293787	7/32 (22%)
		HEAT repeat	943..965	CDD:293787	10/21 (48%)
		HEAT repeat	977..1006	CDD:293787	7/28 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343573
Domainoid	1	1.000	106	1.000	Domainoid score	I1455
eggNOG	1	0.900	-	-		E1_COG5098
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6497
Inparanoid	1	1.050	252	1.000	Inparanoid score	I657
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54099
OrthoFinder	1	1.000	-	-		FOG0004676
OrthoInspector	1	1.000	-	-		oto99586
orthoMCL	1	0.900	-	-		OOG6_102273
Panther	1	1.100	-	-	LDO	PTHR14222
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R215
SonicParanoid	1	1.000	-	-		X3869
TreeFam	1	0.960	-	-
	15	14.790