DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cap-D2 and Ncapd2

DIOPT Version :9

Sequence 1:	NP_651709.1	Gene:	Cap-D2 / 43491	FlyBaseID:	FBgn0039680	Length:	1380	Species:	Drosophila melanogaster
Sequence 2:	NP_666283.1	Gene:	Ncapd2 / 68298	MGIID:	1915548	Length:	1392	Species:	Mus musculus

Alignment Length:	1459	Identity:	417/1459 - (28%)
Similarity:	711/1459 - (48%)	Gaps:	173/1459 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 HDFQFVLPLNASDLINSSG-DQYYVKEIFGAQEIPAKLQECKRKVHLGDPFYIFEHFDLYYSIIE 68
            |:|:|.|||:..:|:.|.| :||.|:|:...:.:.::|:..:.......|..|.||||..|||:.
Mouse     4 HNFEFHLPLSPEELLKSGGVNQYVVREVLPVKHLSSQLRAFQSAFRAQGPLAILEHFDTVYSILH 68

  Fly    69 ARGS--DGASAQNLMRSFDLLYLTVEKLFQDLQPLLTASEPMSNQQRNSYLNLTKMTLFLQVSTV 131
            ...|  .|.....|    :.|...|.:..|:|..:|. ...:|...|:::||..||..:..:..:
Mouse    69 HFRSIEPGLKEDTL----EFLKKVVSRHSQELSSILD-DAALSGSDRSAHLNALKMNCYALIRLL 128

  Fly   132 KKINNSVQQ-AMRDQQLNVQKK--RAKPSEGLEQFPNWEVKRGKFLVQLFNVLQCPLEKLWSPPV 193
            :...|...| ::.|..:..:.|  |||.:.|.:    ||.:|...|..|..:||..:..||:...
Mouse   129 ESFENMTSQTSLIDLDIGGKGKRARAKATLGFD----WEEERQPVLQLLTQLLQLDIRHLWNHSA 189

  Fly   194 AEEDFINLLCDPCYRTIELLPL-RMDNKHVFDTIFQILGTSIKRFNQAMTFPVRILQILRGTEHA 257
            .||:|::|:...|||.:|...: ...|:...:.|..:||.::.|:|..::..|:|:|:|:..||.
Mouse   190 IEEEFVSLVTGCCYRLLENPTISHQKNRSTKEAIAHLLGVALVRYNHMLSATVKIIQMLQHFEHL 254

  Fly   258 AHSVAAGILLLHEEYGISSVFSILIKSIVDALRMD-SSDSSVSKHFSNFLAEFSNIAPSLIVPHL 321
            ...:...:.|...:||:.|:...:::.|......: |.|::.:|.|:.||.|.:...|::::.::
Mouse   255 PPVLVTAVSLWATDYGMKSIVGEIVREIGQKCPQELSRDTAGAKGFAAFLTELAERIPAVLMANM 319

  Fly   322 EKLAEDLLDCQSHTLRNCVLQIIGDTVVSELTSEDLSEELKEVRNEFLEHLMAHILDISAHVRSK 386
            ..|. |.||.:::.:||.||..|.:.|:..|..:.|.|..:|.|::||:.|.||..|:::.|||:
Mouse   320 CILL-DHLDGENYMMRNAVLAAIAEMVLQVLNGDQLEESARETRDQFLDILQAHGHDVNSFVRSR 383

  Fly   387 VLSIWHHLKTQHAIPLNFLTRVLEEAIGRLEDKSSLVRRAAMHLIKSALESNPYSSKLSIDELRA 451
            ||.::..:..|.|:||.....|:..|:|||.|||.||.:.|:.|:.|.|.:||:|.|||..:|..
Mouse   384 VLQLFARIVQQKALPLTRFQAVVALAVGRLADKSVLVCKNAIQLLASFLANNPFSCKLSDIDLAG 448

  Fly   452 KHEHEVQAMEKLNEVLEEERKQEEKL----NDEFSSLAPELLPFIEENLTEFP----DMQFDKEE 508
            ..:.|:|   ||.|:..:.|......    .:|:.::.|||...::: |.:.|    |.|....|
Mouse   449 PLQKEIQ---KLQEMRAQRRSAAATAALDPEEEWDAMLPELKSTLQQ-LLKLPQEEGDHQIADAE 509

  Fly   509 SDETLMERIIPLMREKNYKDVIVLVRKVDFLAGNQNMSSLLKHEEHCVYVLALLKTYHLLAAGFK 573
            :.|.:..||..|:.:.:||..|||.|:...........|..:.||:        ...:||...||
Mouse   510 TAEEVKGRIRQLLAKASYKQAIVLTREATSHFQESEPFSHTEPEEN--------SFLNLLGLIFK 566

  Fly   574 --------------------------------QSSEEMLQQIKTVQFLKDSIDFAVLMTSAFPKL 606
                                            ||::|:::|...||:|:|:..|:..:|.|...:
Mouse   567 GPEASTQGSHGDTDPGLTGSKDSPSVPEPEGSQSNDELVKQEMLVQYLQDAYGFSQKITEAIGII 631

  Fly   607 HEMLMSKTNTDVFEAVDLFTTGYMFGIHGTESGMQRMLQLVWSSDKEKRDAVSDAYKRV-LFSTD 670
            .:|:...|.|.|.|.::.|...:.||:.....|::|||.|:||.:...|:||.:||::: |....
Mouse   632 SKMMYENTTTVVQEVIEFFVMVFQFGVPQALFGVRRMLPLIWSKEPGVREAVLNAYRQLYLNPKG 696

  Fly   671 QTGRAHAIKVVQNLSKFLSEIEYGHYTALESLMTEWVLGGDIDAAVIQVLFERFTLKLEGTTSNE 735
            .:.||.|..::.|||..|.:...|....||.::.|:|...::..||||:|:||.|.|:. ::..|
Mouse   697 DSARAKAQTLIHNLSLLLVDASVGTIQCLEEILCEFVQKDEVKPAVIQLLWERATEKVP-SSPLE 760

  Fly   736 SRLSLQLLIMASQSKSSIVSANTAIIEDIAVGERVRRDPRIFTSCLQLLVNSIDANNTAKYYK-- 798
            ...|:.||.|.::.|..||.:|...:..:.:.|:..:|.|:.......:.|..|....:...:
Mouse   761 RCSSVMLLGMMARGKPEIVGSNLDALVRVGLDEKSPQDYRLAQQVCLAIANISDRRKPSLGERHP 825

  Fly   799 --RQNSDAEFVGKITRLFLDFFFHRS--LYDFDALAMSVFEYFYRMCQAPDVIAQQLVTALLKQF 859
              |...:.....::..:....|.|..  ...|..:|:::   .|::.::|||:..|::....||.
Mouse   826 PFRLPQEHRLFERLQDMVTKGFAHPDPLWIPFKEVAVTL---TYQLAESPDVLCAQMLQGCAKQV 887

  Fly   860 NESWLVKEAAAIVPSPDKADTETVPDSQPLEIPHSQTLTPTQTQADSQSQMQGTLIPVYLVSRLI 924
            .|. |.|.|....|.      ||.|                             .:|.:|:..|:
Mouse   888 LEK-LEKNATEADPK------ETAP-----------------------------RLPTFLLMNLL 916

  Fly   925 FCIGYMTIKEMIFLDMDIYNNMKYRDELTALEERKNRNQQAGSSHNAARLTLNMSAMEVRKRLSG 989
            ...|.:.:::::.|:..:...:..|..|.  ||:::|                  |.|.:::.:
Mouse   917 SLAGDVALQQLVHLEQAVSGELGRRRVLR--EEQEHR------------------AKEPKEKTA- 960

  Fly   990 VAAEPQQEPDDDLV-GATAEDNIAEEIHGICEDMLLYNPDALLSKLAPFIIEICKRPGEFGDPTL 1053
             ::|...|.:..|| ||||:|..||.|..|||..|| :.:.:|:...|.::::|..||.:.:|.|
Mouse   961 -SSETTMEEELGLVGGATADDTEAELIRSICEKELL-DGNQVLAAFVPLLLKVCNNPGLYSNPEL 1023

  Fly  1054 QQAATLALARLMTVSSRFCESNMSFLMNILNLTKNIRIKCNTVVGLSDLTFRFPNIIEPWTGHFY 1118
            ..||:|||.:...:|:.||:|.:..|..:|..:....::.|.:|...||..||||:::|||.|.|
Mouse  1024 CAAASLALGKFCMISAPFCDSQLRLLFTMLEKSSLPTVRSNLMVATGDLAIRFPNLVDPWTPHLY 1088

  Fly  1119 AQLHESNTELRLTAVKMLSHLILNEMIRVKGQIADMALCIVDGNEEIRNITKQFFKEIANKSNIL 1183
            |:|.:...::|.||..:::||||.:|::||||:::||:.::|...:|..:.|.||.|:::|.|.:
Mouse  1089 ARLRDPAQQVRKTAGLVMTHLILKDMVKVKGQVSEMAVLLIDPVPQIAALAKNFFNELSHKGNAI 1153

  Fly  1184 YNVLPDIISRLGDINLNLDEDKYRIIMSYILGLIQKDRQIETLVEKLCLRFPVTRVERQWRDIAY 1248
            ||:||||||||.|....::|:.:..||..:|..|.||:|.|:||||||.||...|.|||:||:||
Mouse  1154 YNLLPDIISRLSDPEGGVEEEPFHTIMKQLLSYITKDKQTESLVEKLCQRFRTARTERQYRDLAY 1218

  Fly  1249 CLGLLTYNERAVKKLMDNMQHYRDKVQVDEVYQSFKLIISNTNKLAKPELKAVVTEFENRLNECL 1313
            |:..|...||.::|::||.:.:.||:..:.|:.:|..::....:.||||.||::.|||.:|..|
Mouse  1219 CMSQLPLTERGLQKMLDNFECFGDKLLDESVFSAFLSVVGKLRRGAKPEGKAIIDEFEQKLRAC- 1282

  Fly  1314 QVNPDTAAQGDQESTPEGQGNRTRA---------------------------APRTKKGGRKPAA 1351
                .|......|....|||...||                           .||..|.||....
Mouse  1283 ----HTRGMDGIEEFETGQGGSQRALSAKKPSAVSRLQPLTSVDSDNDFVTPKPRRTKPGRPQTQ 1343

  Fly  1352 NRNNTVRGRGRRARRDSTSEESFSSSSSD 1380
            .|..:.|........|.:||:..|:..::
Mouse  1344 QRKKSQRKAKVVFLSDESSEDELSAEMTE 1372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cap-D2	NP_651709.1	Cnd1_N	77..243	CDD:289674	43/169 (25%)
		COG5098	85..1269	CDD:227429	358/1236 (29%)
		Cnd1	1091..1254	CDD:289487	74/162 (46%)
Ncapd2	NP_666283.1	Interaction with SMC2 and SMC4. /evidence=ECO:0000250	1..593		170/610 (28%)
		Cnd1_N	75..240	CDD:372385	44/173 (25%)
		COG5098	185..1235	CDD:227429	329/1125 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	569..602		2/32 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	945..966		6/42 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1293..1392		16/80 (20%)
		Bipartite nuclear localization signal. /evidence=ECO:0000250	1332..1353		7/20 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836451
Domainoid	1	1.000	272	1.000	Domainoid score	I1802
eggNOG	1	0.900	-	-		E1_COG5098
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6497
Inparanoid	1	1.050	569	1.000	Inparanoid score	I1057
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54099
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004676
OrthoInspector	1	1.000	-	-		oto93484
orthoMCL	1	0.900	-	-		OOG6_102273
Panther	1	1.100	-	-	LDO	PTHR14222
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R215
SonicParanoid	1	1.000	-	-		X3869
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790