DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cap-D2 and ncapd2

DIOPT Version :9

Sequence 1:	NP_651709.1	Gene:	Cap-D2 / 43491	FlyBaseID:	FBgn0039680	Length:	1380	Species:	Drosophila melanogaster
Sequence 2:	NP_001155974.2	Gene:	ncapd2 / 552978	ZFINID:	ZDB-GENE-050506-59	Length:	1380	Species:	Danio rerio

Alignment Length:	1461	Identity:	423/1461 - (28%)
Similarity:	697/1461 - (47%)	Gaps:	188/1461 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FQFVLPLNASDLINSSG-DQYYVKEIFGAQEIPAKLQECKRKVHLGDPFYIFEHFDLYYSIIE-A 69
            :.|::|:...||:.|.. :||.|:::..|:::|:.:...|..:....|..|.||||..||::: .
Zfish     3 WDFMVPVCLDDLVKSGAVNQYVVQDVLSAKQLPSHINSFKAAMRSQGPLSILEHFDTAYSVLKHC 67

  Fly    70 RGSDGASAQNLMRSFDLLYLTVEKLFQDLQPLLTASEPMSNQQRNSYLNLTKMTLFLQVSTVKKI 134
            |..|.|..::::   :||...|..|...|..||.|. .:|...|...||..||::||.....:.:
Zfish    68 RTVDVAVKEDIL---ELLIQVVRGLSVSLPTLLMAG-TLSAVDRKQQLNAVKMSVFLLCKLTEML 128

  Fly   135 NNSVQQAMRDQQLNVQKK-RAKPSEGLEQFPNWEVKRGKFLVQLFNVLQCPLEKLWSPPVAEEDF 198
            .:   .:.|:..:....| |.|.....:....|:.:|...|..|..:||..:..|||..:.||:|
Zfish   129 ES---DSNRETIVTAPSKGRKKDKAAGKDLLQWDSERDTVLQCLTQLLQLDIRTLWSLSLVEEEF 190

  Fly   199 INLLCDPCYRTIELLPL-RMDNKHVFDTIFQILGTSIKRFNQAMTFPVRILQILRGTEHAAHSVA 262
            ::.:...||:.:|...: .|.||...|.|..:||..:|::|..:...|:::|:|:..|..|...|
Zfish   191 VSCVTCCCYKLLENPTISHMKNKSTRDAIIHVLGIMVKKYNHMLGACVKVIQLLQHFEQLASVCA 255

  Fly   263 AGILLLHEEYGISSVFSILIKSIVDALRMD-SSDSSVSKHFSNFLAEFSNIAPSLIVPHLEKLAE 326
            ..:.....|||:.::...:::.|......: :.:.|..|.||:||:|...:.|..::|::..|..
Zfish   256 QAVAAWSTEYGVKAIVGEIMREIGQKSSEELAREGSGVKAFSSFLSELGTLVPETMIPNISVLLT 320

  Fly   327 DLLDCQSHTLRNCVLQIIGDTVVSELTSEDLSEELKEVRNEFLEHLMAHILDISAHVRSKVLSIW 391
            . |:.:|.:||..|.:|:|:.:|..|:.:.|.:..:..|:.||:.|..||.|..:|||::||.::
Zfish   321 H-LEGESPSLRVAVCEILGEVLVRVLSGDKLDDSARASRDRFLDTLQEHIHDAHSHVRARVLQVY 384

  Fly   392 HHLKTQHAIPLNFLTRVLEEAIGRLEDKSSLVRRAAMHLIKSALESNPYSSKLSIDELRAKHEHE 456
            ..:....|:||:..|.|:|..:|||.|||..|.::|:.|:.:.:..||||.|||..:|:...|.|
Zfish   385 TRIVNSKALPLSRYTEVMELTVGRLGDKSVNVCKSAIQLLAAFIAHNPYSCKLSSVDLKKPLEKE 449

  Fly   457 VQAMEKLNEVLEEERKQEE----KLNDEFSSLAPELLPFIEENLTEFPDMQFDKEE--------- 508
               |.||.|:.:.:.:|..    ...|.:.::.||:...::..|....:.:.|:||
Zfish   450 ---MAKLKEMRDAQAEQVPVAVITATDLWDAMKPEVELTVKALLEPGSEEEDDEEEEEEAAEGDR 511

  Fly   509 SDETLMERIIPLMREKNYKDVIVLVRKVDFLAGNQNMSSLLK--HEEHCVYVLALLKTYHLLAAG 571
            ||.....:|...:||..||..:.|..:...|....:..|.|.  :.|..:..||.|
Zfish   512 SDRDTAVQIAQFLRESKYKKAVGLCMRAHSLFPESSFFSDLADLNAESLINTLATL--------- 567

  Fly   572 FKQSSEEMLQQIKT-----------------------VQFLKDSIDFAVLMTSAFPKLHEMLMSK 613
            ||...||..:.:.|                       ||:|||:..||:.:..|...::.||..|
Zfish   568 FKGPEEETPEAVSTDAPPTPQKESEGRESELKKQEMLVQYLKDTECFALQVERAIAVINNMLYWK 632

  Fly   614 TNTDVFEAVDLFTTGYMFGIHGTESGMQRMLQLVWSSDKEKRDAVSDAYKRVLFSTD-QTGRAHA 677
            |.|.|.|||....|.:.|.:..:..|:::||.||||:|...:|||..||:|:..:.: :..||.|
Zfish   633 TTTIVQEAVQFCVTAFEFSVADSVCGVRKMLPLVWSTDVTIKDAVIQAYRRLYLNPNGENTRAKA 697

  Fly   678 IKVVQNLSKFLSEIEYGHYTALESLMTEWVLG-GDIDAAVIQVLFERFTLKLEGTTSNESRLSLQ 741
            ..:|.:||..:.:...|....||.::.|:... ..:..:|:|||:|||:.|.| |.:...|.::.
Zfish   698 HTLVDSLSDLMVDASLGTIQCLEEIVQEFFSSESALQTSVMQVLWERFSGKRE-TKALHRRAAVL 761

  Fly   742 LLIMASQSKSSIVSANTAIIEDIAVGERVRRDPRIFTSCLQLLVNSIDANNTAKYYKRQNSDAEF 806
            ||.||.:::..:|.:|...:..:|:||:|..|..:....|..:.|..|       :.||:....|
Zfish   762 LLGMAGRAEREVVLSNLDTLCSVALGEKVAEDYLLARDTLITITNITD-------HVRQSKGVPF 819

  Fly   807 VGKITRLFLDFFFHRSLYDFDALAMSVFE--------------YFYRMCQAPDVIAQQLV----T 853
                 ||.:|......|  ..|:|..|.:              ..|.:.::||.:..:|:    .
Zfish   820 -----RLPMDHHLFSCL--SQAIADGVVQSDPHWQTFMEQAVRLIYFLAESPDQLCSRLLQRSAR 877

  Fly   854 ALLKQFNESWLVKEAAAIVPSPDKADTETVPDSQPLEIPHSQTLTPTQTQADSQSQMQGTLIPVY 918
            .||:|..|.                   ..||...|:...||.         |:.|:.    .|.
Zfish   878 LLLEQITEG-------------------GEPDQSQLQEGASQV---------SEEQVN----CVS 910

  Fly   919 LVSRLIFCIGYMTIKEMIFLDMDIYNNMKYRDELTALEERKNRNQQAGSSHNAARLTLNMSAMEV 983
            |...|..| |.:...::..|:..:.:.::.|   ...:|.|...::|.:|...|    |.|.:
Zfish   911 LAQVLSLC-GAVAFWQVSHLERSVSSELRRR---RGEKEEKEEKEKAPASKKGA----NDSCV-- 965

  Fly   984 RKRLSGVAAEPQQEPDDDLVGATAEDNIAEEIHGICEDMLLYNPDALLSKLAPFIIEICKRPGEF 1048
                         |.:..||||:|||..||.|..|||..||...: :||...|.::::|..||::
Zfish   966 -------------EEELGLVGASAEDTEAEFIRKICETELLAEGN-MLSAFLPLLVKVCSSPGKY 1016

  Fly  1049 GDPTLQQAATLALARLMTVSSRFCESNMSFLMNILNLTKNIRIKCNTVVGLSDLTFRFPNIIEPW 1113
            ..|.|..||.|||::.|.:|...|:.::..|..:|..::...::.||:|.|.|||.|||||:|||
Zfish  1017 SHPQLTTAACLALSQYMMISPAVCKDHIRLLFTVLEKSQLPVVRANTIVALGDLTVRFPNILEPW 1081

  Fly  1114 TGHFYAQLHESNTELRLTAVKMLSHLILNEMIRVKGQIADMALCIVDGNEEIRNITKQFFKEIAN 1178
            |.:.||:|.:.|..:||||:.:|:.|:|.::::||||::::|:.::|....|.::...||.|::.
Zfish  1082 TPNLYARLSDENASVRLTAITVLTQLVLKDVMKVKGQVSEVAVLLLDPEPHIASLALNFFNELSA 1146

  Fly  1179 KSNILYNVLPDIISRLGDINLNLDEDKYRIIMSYILGLIQKDRQIETLVEKLCLRFPVTRVERQW 1243
            |.|.:||:||||||||.|....::|:.:..||..:...|.|:||.|:||||||.||...:.||||
Zfish  1147 KDNAIYNLLPDIISRLSDPERGMNEEDFNTIMKQLFSYITKERQTESLVEKLCQRFRTAKTERQW 1211

  Fly  1244 RDIAYCLGLLTYNERAVKKLMDNMQHYRDKVQVDEVYQSFKLIISNTNKLAKPELKAVVTEFENR 1308
            .|:|..|.||:..||..|||.:....|.||:....|||....|.:...:.|||:.||.|.::|.|
Zfish  1212 ADLAVSLSLLSVCERGFKKLQECWDCYSDKLAEPGVYQPLLSIAAKLRRRAKPQFKAQVEDYEKR 1276

  Fly  1309 L------------NECLQVNPDTAAQGDQESTPEGQGNRTRAAP----RTKKGGRKPAANRNNTV 1357
            |            ||          :.:|::..:.|...|..||    ||.:|..||..:.::.|
Zfish  1277 LTAVHTKGLENVENE----------EREQQADTQSQNLHTPQAPKSVRRTTRGRGKPKVDDSDLV 1331

  Fly  1358 RGRGRRAR--------RDSTSEESFSSSSSD 1380
            ..|..|||        .|...||....:.|:
Zfish  1332 TPRKSRARPKPAITFTSDEEEEEDAVMAESE 1362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cap-D2	NP_651709.1	Cnd1_N	77..243	CDD:289674	44/167 (26%)
		COG5098	85..1269	CDD:227429	364/1244 (29%)
		Cnd1	1091..1254	CDD:289487	74/162 (46%)
ncapd2	NP_001155974.2	Cnd1_N	73..236	CDD:289674	45/169 (27%)
		COG5098	78..1221	CDD:227429	357/1233 (29%)
		HEAT repeat	314..342	CDD:293787	8/28 (29%)
		HEAT repeat	360..390	CDD:293787	11/29 (38%)
		HEAT repeat	400..426	CDD:293787	11/25 (44%)
		HEAT repeat	1002..1033	CDD:293787	11/30 (37%)
		HEAT repeat	1043..1073	CDD:293787	9/29 (31%)
		Cnd1	1057..1222	CDD:289487	74/164 (45%)
		HEAT repeat	1080..1106	CDD:293787	12/25 (48%)
		HEAT repeat	1116..1144	CDD:293787	8/27 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579974
Domainoid	1	1.000	256	1.000	Domainoid score	I2000
eggNOG	1	0.900	-	-		E1_COG5098
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6497
Inparanoid	1	1.050	545	1.000	Inparanoid score	I1124
OMA	1	1.010	-	-		QHG54099
OrthoDB	1	1.010	-	-		D124981at33208
OrthoFinder	1	1.000	-	-		FOG0004676
OrthoInspector	1	1.000	-	-		oto41602
orthoMCL	1	0.900	-	-		OOG6_102273
Panther	1	1.100	-	-	LDO	PTHR14222
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R215
SonicParanoid	1	1.000	-	-		X3869
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800