DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cap-D2 and cnd1

DIOPT Version :9

Sequence 1:	NP_651709.1	Gene:	Cap-D2 / 43491	FlyBaseID:	FBgn0039680	Length:	1380	Species:	Drosophila melanogaster
Sequence 2:	NP_596329.1	Gene:	cnd1 / 2541201	PomBaseID:	SPBC776.13	Length:	1158	Species:	Schizosaccharomyces pombe

Alignment Length:	1283	Identity:	297/1283 - (23%)
Similarity:	556/1283 - (43%)	Gaps:	234/1283 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 QECKRKVHLGDPFYIFEHF-DLYYSIIEARGSDGASAQNLMRSFDLLYLTVEKLFQDLQPLLTAS 105
            ::|..|:     |.|..|| ||           .:|.:|  :.:|||...:......|:.:::|:
pombe    54 EDCLEKL-----FAICSHFADL-----------SSSVRN--KVYDLLTSNISSESAILEDMISAN 100

  Fly   106 E-----PMSNQQRNSYLNLTKMTLFLQVSTVKKINNSVQQAMRDQQLNVQKKRAKPSEGLEQFP- 164
            .     |.:|      |..|.:...|.|:::...|          ||:|.:......:|.::.|
pombe   101 ATDFTVPQTN------LETTGIAFQLTVNSLSSSN----------QLSVIRSSTNTVKGRKKNPT 149

  Fly   165 ---NWE-VKRGKFLVQ-LFNVLQCPLEKLWSPPVAEEDFINLLCDPCYRTIELLPLRMDNKHVFD 224
               ||. :.....|:. :..:.|..|.::|:.....:.|::|...|.|..:| ..:.:.|.....
pombe   150 TNSNWNGISHVNALLDAIITLFQKKLSRVWTTSSERDMFLSLFLKPIYTLME-SEINIKNASFRS 213

  Fly   225 TIFQILGTSIKRFNQAMTFPVRILQILRGTEHAAHSVAAGILLLHEEYGISSVFSILIKSIVDAL 289
            .:|.|:|.:::..|........|:|.|:..||.:...|..:.::..::...::...:|:::. :|
pombe   214 RLFNIIGLAVQFHNHTTAAETNIIQNLQYFEHLSEYAADLVHIVTVQFNSVTLAEGIIRTLC-SL 277

  Fly   290 RMDSSDSSVSKHFSNFLAEFSNIAPSLIVPHLEKLAEDLLDCQSHTLRNCVLQIIGDTVVSELTS 354
            ..:.:|....|..:.||...|::.|:|.:..|.:|.: |||.:|:|||..:::::.:.|:.::..
pombe   278 EFNDNDVKGPKQVALFLVRLSSLIPNLCLKQLTQLVK-LLDSESYTLRCAIIEVLANVVIDQIHD 341

  Fly   355 E---DLSEELKEVRNEFLEHLMAHILDISAHVRSKVLSIWHHLKTQHAIPLNFLTR---VLEEAI 413
            |   ::||.:.......::.|...:||||.:.|:|||.::..:   ..:|:.:..:   :.|..|
pombe   342 EAQNEMSESVPATVQSLMDLLSERLLDISPYCRTKVLHVFIKI---FDLPIKYPRKRQEIAELVI 403

  Fly   414 GRLEDKSSLVRRAAMHLIKSALESNPYS-------------SKLSIDELRAKHEHEVQAMEKLNE 465
            ..|:|:||.|||.|:.|....|.::|:|             ..|||.|            |:||.
pombe   404 RCLQDRSSHVRRNAIKLFSKLLTTHPFSVMHNGLLTRNIWEKGLSIIE------------EQLNS 456

  Fly   466 VLEEERKQEEKLNDEFSSLAPELLPFIEENLTEFPDM-QFDKEESDETLMERIIPLMREKNYKDV 529
            :   :.||:||:.|  |.|.      ::|||.|...| |.|:....|:.:|..:     ..|.|.
pombe   457 L---QPKQQEKVVD--SELE------VDENLLEDATMIQDDESHEGESHLENSL-----SEYVDS 505

  Fly   530 IVLVRKVDFLAGNQNMSSLLKHEEHCVYVLALLKTYHLLAAGFKQSSEEMLQQIKTVQFLKDSID 594
            :                                            .:||:::...|.:|..:::.
pombe   506 V--------------------------------------------PAEEIVKVNLTKRFYLEALQ 526

  Fly   595 FAVLMTSAFPKLHEMLMSKTNTDVFEAVDLFTTGYMFGIHGTESGMQRMLQLVW---SSDKEK-- 654
            :..::.:....:.::|.:|..::|.|::|.|.....|||..::..:::|:.|:|   :||:..
pombe   527 YIDIVEAGAKIISQLLFAKNKSEVIESMDFFVFCNSFGISSSKLYIKKMIHLIWVKGTSDEGNNI 591

  Fly   655 RDAVSDAYKRVLFS---TDQTGRAHAIKVVQNLSKFLSEIEYGHYTALESLMTEWVLGGDIDAAV 716
            ::.|...||.:.|.   ...|..| |..:.:||.....:......|:||.::...:..|.....|
pombe   592 QNHVLSCYKTLFFEPPPNSGTNEA-ANYIARNLISLTYDASLAELTSLEQMLCILMKDGYFSHLV 655

  Fly   717 IQVLFERFTLKLEGTTSNESRLSLQLLIMASQSKSSIVSANTAIIEDIAVGERVRRDPRIFTSCL 781
            |..|::.::.:.:..:..:.|.|:.::.|.:...:.:|......:..|.:|.....|
pombe   656 ITKLWQVYSYQKKDISRTQRRGSIIVIGMLALGNTDVVMQGLDHLIQIGLGPPGLED-------- 712

  Fly   782 QLLVNSIDANNTAKYYKRQNSDAE------------FVGKITRLFLDFFFHRSLYDFDALAMSVF 834
                 .:.|..|....||...||.            ...|:..|.|...|....:..:..|:
pombe   713 -----LVLARYTCIAIKRIGKDASGSSNINFPNSHTLCQKLCMLLLRPSFSEEWFGLEEQAI--- 769

  Fly   835 EYFYRMCQAPDVIAQQLVTALLKQ-FNESWLVKEAAAIVPSPDKADTETVPDSQPLEIPHSQTLT 898
            |..|.:.:.||.:...::..|.|| |..|    .......:.|.|..|.:.||     |..:||.
pombe   770 EAIYAVAKHPDELCTNIILLLTKQLFKPS----NHENTTSNDDHAMDEDLDDS-----PEEETLK 825

  Fly   899 PTQTQADSQSQMQGTLIPVYLVSRLIFCIGYMTIKEMIFLDMDIYNNMKYRDELTALEERKNRNQ 963
            ..:.            |.:.| :.|||.:|::.||::::::   |...:::       .||
pombe   826 DEEE------------IGIRL-AHLIFLVGHVAIKQLVYIE---YCEAEFK-------RRK---- 863

  Fly   964 QAGSSHNAARLTLNMSAMEVRKRLSGVAAEPQQEPDDDLVGATAEDNIAEEIHGICEDMLLYNPD 1028
                 .:|.||.:..|    ...::|     |:..:.||:..|:||:.:|.:..|.|..|||..:
pombe   864 -----ADAERLAVQNS----NNPING-----QETSEYDLITGTSEDDFSEAMTFIRERELLYGEN 914

  Fly  1029 ALLSKLAPFIIEICKRPGEFGDPTLQQAATLALARLMTVSSRFCESNMSFLMNILNLTKNIRIKC 1093
            :|||:.||.::|:|.......:.:|..||:|.|::.|.:|:.||..::..|:.||....|..|:.
pombe   915 SLLSRFAPLVVELCSNHKSHNNQSLLLAASLTLSKFMCLSNNFCMEHLPLLITILEKCDNPIIRN 979

  Fly  1094 NTVVGLSDLTFRFPNIIEPWTGHFYAQLHESNTELRLTAVKMLSHLILNEMIRVKGQIADMALCI 1158
            |.|:||:|||..|.:.|:..:.:.|.:|.:..:.::.|....|:.|||...|:||||:..||..:
pombe   980 NLVIGLADLTVCFNHFIDEISEYLYRRLMDEESSVKKTCFMTLAFLILAGQIKVKGQLGIMARSL 1044

  Fly  1159 VDGNEEIRNITKQFFKEIANKSNILYNVLPDIISRLGDINLNLDED--KYRIIMSYILGLIQKDR 1221
            .|.:..|.::.:.||.:.|.|.|.:||...||.|.|.......|||  |::.|:.::...|:|:|
pombe  1045 EDEDARISDLARMFFTDFAAKDNSVYNNFIDIFSVLSRSAEEQDEDDAKFKRIIRFLTSFIEKER 1109

  Fly  1222 QIETLVEKLCLRFPVTRVERQWRDIAYCLGLLTYNERAVKKLMDNMQH 1269
            ..:.|.|:|..|....:.:|||..:.|.|.||.:....::||:|:..|
pombe  1110 HTKQLAERLAARLDRCKTQRQWDHVVYALSLLPHKADNIQKLIDDGYH 1157

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cap-D2	NP_651709.1	Cnd1_N	77..243	CDD:289674	34/176 (19%)
		COG5098	85..1269	CDD:227429	286/1237 (23%)
		Cnd1	1091..1254	CDD:289487	55/164 (34%)
cnd1	NP_596329.1	COG5098	9..1158	CDD:227429	297/1283 (23%)
		Cnd1_N	72..232	CDD:289674	35/178 (20%)
		HEAT repeat	309..342	CDD:293787	10/33 (30%)
		HEAT repeat	357..383	CDD:293787	9/25 (36%)
		HEAT repeat	394..424	CDD:293787	11/29 (38%)
		Cnd1	974..1142	CDD:289487	56/167 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	153	1.000	Domainoid score	I1072
eggNOG	1	0.900	-	-		E1_COG5098
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6497
Inparanoid	1	1.050	275	1.000	Inparanoid score	I691
OMA	1	1.010	-	-		QHG54099
OrthoFinder	1	1.000	-	-		FOG0004676
OrthoInspector	1	1.000	-	-		oto101215
orthoMCL	1	0.900	-	-		OOG6_102273
Panther	1	1.100	-	-	LDO	PTHR14222
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R215
SonicParanoid	1	1.000	-	-		X3869
TreeFam	1	0.960	-	-
	14	13.860