Protein Alignment Cap-D2 and ncapd2

DIOPT Version :9

• Sequence 1: NP_651709.1
• Gene: Cap-D2 / 43491
• FlyBaseID: FBgn0039680
• Length: 1380
• Species: Drosophila melanogaster
• Sequence 2: XP_002941732.2
• Gene: ncapd2 / 100491414
• XenbaseID: XB-GENE-5854776
• Length: 1368
• Species: Xenopus tropicalis
• Alignment Length: 1442
• Identity: 438/1442 - (30%)
• Similarity: 725/1442 - (50%)
• Gaps: 179/1442 - (12%)

  Fly     7 FQFVLPLNASDLINSSG-DQYYVKEIFGAQEIPAKLQECKRKVHLGDPFYIFEHFDLYYSII-EA 69
            |.|.:||...||:.|.| .||.|:|:...:::.|:....:.......|..|.:|||..|||: ..
 Frog     3 FHFHIPLAFRDLLKSGGIGQYVVQEVLPVRQLDAQFDAFQSSFRTEGPLCILQHFDTLYSILHHF 67

  Fly    70 RGSDGASAQNLMRSFDLLYLTVEKLFQDLQPLLTASEPMSNQQRNSYLNLTKMTLFLQVSTVKKI 134
            |..|.|..:   |..:|:.....:...:| |.:.....:|..||.::||..||..|:....|:..
 Frog    68 RSLDTAIKE---RVLELMVKVASRHASEL-PAILEDLNLSAPQRAAHLNALKMNCFILTQLVEAF 128

  Fly   135 NNSVQQAMRDQQLNVQ-----KKRAKPSEGLEQFPNWEVKRGKFLVQLFNVLQCPLEKLWSPPVA 194
            .....:|...   ||:     ||....|||.    :||.:|...|..|.::||..:.:|||..|.
 Frog   129 EAETYKASLG---NVEPSGKGKKAKSKSEGF----SWEAERESILQALTHLLQLEIRRLWSMSVV 186

  Fly   195 EEDFINLLCDPCYRTIELLP--LRMDNKHVFDTIFQILGTSIKRFNQAMTFPVRILQILRGTEHA 257
            ||:|::::...||:.:| .|  :...||...:.:..:||.::||:|..::..|:::|:|:..||.
 Frog   187 EEEFVSMVTGCCYKMME-NPNIVAAKNKSTREALGHLLGVTVKRYNHMLSASVKVIQLLQHFEHL 250

  Fly   258 AHSVAAGILLLHEEYGISSVFSILIKSIVDALRMD-SSDSSVSKHFSNFLAEFSNIAPSLIVPHL 321
            ...:...:.|...|||:..|...:::.|......| |.:||..|.|:.||.|.:...|::::|.:
 Frog   251 PSVLVHAVSLWATEYGMKPVIGEIMREIGQKCSQDLSRESSGFKAFATFLTELAERIPAIMMPSI 315

  Fly   322 EKLAEDLLDCQSHTLRNCVLQIIGDTVVSELTSEDLSEELKEVRNEFLEHLMAHILDISAHVRSK 386
            ..|. |.||.:::.:||.||.::|:.|:..|:.:.|.|..|..|::||:.|..||.|::.:||..
 Frog   316 SVLL-DYLDGENYMMRNAVLTVMGEMVLRVLSGDQLEEAEKSTRDQFLDTLQEHIHDVNTYVRCC 379

  Fly   387 VLSIWHHLKTQHAIPLNFLTRVLEEAIGRLEDKSSLVRRAAMHLIKSALESNPYSSKLSIDELRA 451
            ||.|::.:..:.|:||.....|:...:|||.|||..|.:.|:.|:.|.|.:||::.|||..:|:.
 Frog   380 VLQIYNRVVQEKALPLTRFQSVVTLVVGRLFDKSVNVCKNAIQLLASFLANNPFTCKLSSIDLKE 444

  Fly   452 KHEHEVQAMEKLNEVLEEERKQEEKL----NDEFSSLAPELLPFI----EENLTEFPDMQFDKEE 508
            ..|.|.   :||.|:.|:.:..:..:    .:|:.::.||:....    :|:..|..|...|:.|
 Frog   445 PLEKET---KKLKEMREKYQGPKPAVVISPEEEWEAMLPEVQEAFNVVQQESKEEADDDAQDEVE 506

  Fly   509 SDETLMERIIPLMREKNYKDVIVLVRK-VDFLAGNQNMSSLLKHEEHCVYVLALL-KTYHLLAAG 571
            |.:.|.|:|:.|:|:.:||:.|.|.:: ::....:...|.....||.   |||:| |.:....||
 Frog   507 SSQQLREQILLLLRKTSYKNAIRLAQEGIERFQEDPLFSEGESEEES---VLAILEKIFTGKEAG 568

  Fly   572 FKQ--------------SSEE----------MLQQIKTVQFLKDSIDFAVLMTSAFPKLHEMLMS 612
            .:|              |.||          :.:|...||:|.|:..|||.:..|...:.:|:..
 Frog   569 SEQPATTDQDDAPVKPTSDEEQPSAEVQQSDLGKQEMLVQYLSDAHHFAVKIEEAIDVISKMMYE 633

  Fly   613 KTNTDVFEAVDLFTTGYMFGIHGTESGMQRMLQLVWSSDKEKRDAVSDAYKRV-LFSTDQTGRAH 676
            ...:.|.|.::.|.|...||:.....|::|||.||||.:...|:||..||:|: |.|..::.|..
 Frog   634 TAVSVVQEVIEFFVTVSQFGVSQALLGVRRMLPLVWSKEPGVREAVLSAYRRLYLTSNGESERVK 698

  Fly   677 AIKVVQNLSKFLSEIEYGHYTALESLMTEWVLGGDIDAAVIQVLFERFTLKLEGTTSNESRLSLQ 741
            |..:|:|||..:.:...|....||.:::|::..|||...|||:|:|:||.| ..:::.|.|.::.
 Frog   699 AQALVRNLSLLMVDSSAGILQCLEEIVSEFIQKGDIHPTVIQLLWEKFTQK-SPSSALERRAAIM 762

  Fly   742 LLIMASQSKSSIVSANTAIIEDIAVGERVRRDPRIFTSCLQLLVNSIDANNTAKYYKRQNSDAEF 806
            ||.|.::.:..||.:|...:..:.:||:|:.|.::    .|.:.|.|        .|..:|....
 Frog   763 LLGMMTKGQPEIVMSNLDTLVTVGLGEQVQEDYQL----AQEVCNCI--------LKITDSQKPS 815

  Fly   807 VGKITRLFL-----DFFFHRSLYDFDALAMSVFEYF----------YRMCQAPDVIAQQLVTALL 856
            :||.|..|.     ..|.|.:......:.:|...:.          |.:.:.|:.|..:::
 Frog   816 LGKSTEPFRLPKDHSLFVHLTEAVAGGIGLSGLHWLPFKETAVRLVYELGEEPEEICSEIL---- 876

  Fly   857 KQFNESWLVKEAAAIVPSPDKADTETVPDSQPLEIPHSQTLTPTQTQADSQSQMQGTLIPVYLVS 921
                                            |...| :.|...|||.::.:      :|.||::
 Frog   877 --------------------------------LRCSH-KVLDGHQTQDEAPT------LPAYLLT 902

  Fly   922 RLIFCIGYMTIKEMIFLDMDIYNNMKYRDELTALEERKNRNQQAGSSHNAARLTLNMSAMEVRKR 986
            .|:...|.:.:::::.|:..:.:.::.|..|...:|                      |.:|.|:
 Frog   903 HLLSLAGDVALQQVVHLERAVSSELRRRRVLKEEQE----------------------AEKVGKQ 945

  Fly   987 LSGVAAEPQQEPDDDLVGATAEDNIAEEIHGICEDMLLYNPDALLSKLAPFIIEICKRPGEFGDP 1051
            ....|.|...|.:..||||:|:|..||.|..||:..|| .....||...|.|:.||..||.:.||
 Frog   946 RKSKANESTMEEELGLVGASADDIEAELIRKICDTELL-GEQQYLSAFLPLILRICNNPGRYNDP 1009

  Fly  1052 TLQQAATLALARLMTVSSRFCESNMSFLMNILNLTKNIRIKCNTVVGLSDLTFRFPNIIEPWTGH 1116
            .|...||||||:.|.:||.||::::..|..:|..:....::.|.::.|.||:.||||:|||||.:
 Frog  1010 DLCTVATLALAKFMMISSDFCDTHLRLLFTLLEKSPLPSVRSNIMIALGDLSIRFPNLIEPWTPN 1074

  Fly  1117 FYAQLHESNTELRLTAVKMLSHLILNEMIRVKGQIADMALCIVDGNEEIRNITKQFFKEIANKSN 1181
            .||:|.:.:.|:|.||..:::||||.:|::||||:::||:.:::.::||..:.:.||.|::||.|
 Frog  1075 LYARLRDPSREVRKTAGLVMTHLILKDMVKVKGQVSEMAVLLIESDQEIAALARNFFNELSNKGN 1139

  Fly  1182 ILYNVLPDIISRLGDINLNLDEDKYRIIMSYILGLIQKDRQIETLVEKLCLRFPVTRVERQWRDI 1246
            .:||:||||||||.|.:..::|:.::.||..:|..|.||:|.|:||||:|.||...|.||||||:
 Frog  1140 AVYNLLPDIISRLSDPDCGVEEEAFQTIMKQLLSYITKDKQTESLVEKMCHRFRTARTERQWRDL 1204

  Fly  1247 AYCLGLLTYNERAVKKLMDNMQHYRDKVQVDEVYQSFKLIISNTNKLAKPELKAVVTEFENRLNE 1311
            |:||.||.::|:.::|:.|....|.||:..|.||.||...::...:.|||||||::.|||.:||.
 Frog  1205 AHCLALLPFSEKGLRKMQDCFDCYGDKLSDDAVYNSFLSTVAKMRRGAKPELKALIDEFEQKLNR 1269

  Fly  1312 CLQVNPDTAAQG-DQESTPE--GQGNRTRAAPRT-----KKG-------GRKPAANRNNTVRGRG 1361
            |  .|......| .:|..||  .|..:::..|.|     |||       ..||.|:|    :.|.
 Frog  1270 C--HNKGLENMGVPEEPNPECDQQPPKSKRPPLTCMNSVKKGKPENEFQTPKPQASR----KSRR 1328

  Fly  1362 RRARRDSTSEES 1373
            :.|...|:.|||
 Frog  1329 KVAVTFSSDEES 1340

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cap-D2	NP_651709.1	Cnd1_N	77..243	CDD:289674	46/172 (27%)
		COG5098	85..1269	CDD:227429	371/1241 (30%)
		Cnd1	1091..1254	CDD:289487	77/162 (48%)
ncapd2	XP_002941732.2	COG5098	57..1223	CDD:227429	379/1263 (30%)
		HEAT repeat	1033..1062	CDD:293787	6/28 (21%)
		HEAT repeat	1072..1105	CDD:293787	13/32 (41%)
		HEAT repeat	1141..1169	CDD:293787	13/27 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	281	1.000	Domainoid score	I1643
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6497
Inparanoid	1	1.050	591	1.000	Inparanoid score	I970
OMA	1	1.010	-	-		QHG54099
OrthoDB	1	1.010	-	-		D124981at33208
OrthoFinder	1	1.000	-	-		FOG0004676
OrthoInspector	1	1.000	-	-		oto103721
Panther	1	1.100	-	-	LDO	PTHR14222
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R215
SonicParanoid	1	1.000	-	-		X3869
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.110