DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Bub3 and BUB3.2

DIOPT Version :9

Sequence 1:	NP_001287587.1	Gene:	Bub3 / 43490	FlyBaseID:	FBgn0025457	Length:	326	Species:	Drosophila melanogaster
Sequence 2:	NP_175413.1	Gene:	BUB3.2 / 841414	AraportID:	AT1G49910	Length:	339	Species:	Arabidopsis thaliana

Alignment Length:	327	Identity:	146/327 - (44%)
Similarity:	206/327 - (62%)	Gaps:	13/327 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KLNNPPEDLISAVKFGPKSNQYMAASSWDGTLRFYDVPANQLRQKFVQDAPLLDCAFMDIVHVVS 71
            :|:|||.|.||.::|...|: ::..||||.::|.||...:.:|.:|.....:|||.|.|.....|
plant    10 ELSNPPSDGISNLRFSNNSD-HLLVSSWDKSVRLYDANGDLMRGEFKHGGAVLDCCFHDDSSGFS 73

  Fly    72 GSLDNQLRLFDVNTQAESIIGAHEEPIRCVEHAEYVNGILTGSWDNTVKLWDMR-----EKRCVG 131
            ...|.::|..|.|...|.::|.||:|:||||::.....::|||||.|:|.||.|     |:..:|
plant    74 VCADTKVRRIDFNAGKEDVLGTHEKPVRCVEYSYAAGQVITGSWDKTIKCWDPRGASGTERTQIG 138

  Fly   132 TFEQNNGKVYSMSVIDEKIVVATSDRKVLIWDLRKMDSYIMKRESSLKYQTRCIRLFPNKEGYVM 196
            |:.|.. :|.|:|::..::||||:.|.|.|:|||.|.....:|||||||||||:|.:||..||.:
plant   139 TYMQPE-RVNSLSLVGNRLVVATAGRHVNIYDLRNMSQPEQRRESSLKYQTRCVRCYPNGTGYAL 202

  Fly   197 SSIEGRVAVEYLDHDPEVQRRKFAFKCHRNREQNIEQIYPVNALSFHNVYQTFATGGSDGIVNIW 261
            ||:||||::|:.|.....|.:|:||||||..|...:.:|||||::||.:|.|||:||.||.||||
plant   203 SSVEGRVSMEFFDLSEAAQAKKYAFKCHRKSEDGRDIVYPVNAIAFHPIYGTFASGGCDGFVNIW 267

  Fly   262 DGFNKKRLCQFHEYDTSISTLNFSSDGSALAIGCSYLDQLPETPATVPH--PAIYIRYPTDQETK 324
            ||.|||||.|:.:|.|||:.|:||.||..||:..||..:    ....||  .||::|...:.|.|
plant   268 DGNNKKRLYQYSKYPTSIAALSFSRDGGLLAVASSYTFE----EGDKPHEPDAIFVRSVNEIEVK 328

  Fly   325 QK 326
            .|
plant   329 PK 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bub3	NP_001287587.1	WD40	<10..296	CDD:225201	135/290 (47%)
		WD40	16..262	CDD:295369	111/250 (44%)
		WD40 repeat	16..53	CDD:293791	12/36 (33%)
		WD40 repeat	59..93	CDD:293791	11/33 (33%)
		WD40 repeat	98..134	CDD:293791	17/40 (43%)
		WD40 repeat	141..175	CDD:293791	13/33 (39%)
		WD40 repeat	182..222	CDD:293791	19/39 (49%)
		WD40 repeat	237..283	CDD:293791	29/45 (64%)
BUB3.2	NP_175413.1	WD40	16..302	CDD:421866	132/287 (46%)
		WD40 repeat	19..55	CDD:293791	12/36 (33%)
		WD40 repeat	61..95	CDD:293791	11/33 (33%)
		WD40 repeat	100..138	CDD:293791	15/37 (41%)
		WD40 repeat	147..181	CDD:293791	13/33 (39%)
		WD40 repeat	188..228	CDD:293791	19/39 (49%)
		WD40 repeat	243..280	CDD:293791	25/36 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	98	1.000	Domainoid score	I2411
eggNOG	1	0.900	-	-		E1_KOG1036
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3470
Inparanoid	1	1.050	290	1.000	Inparanoid score	I834
OMA	1	1.010	-	-		QHG53489
OrthoDB	1	1.010	-	-		D1048963at2759
OrthoFinder	1	1.000	-	-		FOG0003514
OrthoInspector	1	1.000	-	-		otm3177
orthoMCL	1	0.900	-	-		OOG6_102928
Panther	1	1.100	-	-	O	PTHR10971
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2886
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840