DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Bub3 and rae1

DIOPT Version :9

Sequence 1:	NP_001287587.1	Gene:	Bub3 / 43490	FlyBaseID:	FBgn0025457	Length:	326	Species:	Drosophila melanogaster
Sequence 2:	NP_001017142.1	Gene:	rae1 / 549896	XenbaseID:	XB-GENE-995595	Length:	368	Species:	Xenopus tropicalis

Alignment Length:	308	Identity:	103/308 - (33%)
Similarity:	163/308 - (52%)	Gaps:	17/308 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EFKLNNPPEDLISAVKFGPKS--NQYMAASSWDGTLRFYDVPAN-QLRQKFVQ--DAPLLD-CAF 63
            :.::.:||:|.||.:.|.|.:  ..::.|.||...:|.::|..| |...|..|  ..|:|| |..
Frog    31 DIEVTSPPDDSISCLSFSPPTLPGNFLIAGSWANDVRCWEVQDNGQTIPKAQQMHTGPVLDVCWS 95

  Fly    64 MDIVHVVSGSLDNQLRLFDVNTQAESIIGAHEEPIRCVEHAEYVN--GILTGSWDNTVKLWDMRE 126
            .|...|.:.|.|...:::|:|:.....|..|:.||:.|...:..|  .|:|||||.::|.||.|.
Frog    96 DDGSKVFTASCDKTAKMWDLNSNQSIQIAQHDAPIKTVHWVKAPNYSCIMTGSWDKSLKFWDTRS 160

  Fly   127 KRCVGTFEQNNGKVYSMSVIDEKIVVATSDRKVLIWDLRKMDSYIMKRESSLKYQTRCIRLFPNK 191
            ...:.|. |...:.|...|:....||||::|.::::.|....|...:.:|.||:|.||:.:|.:|
Frog   161 PNPLLTL-QLPERCYCADVVYPMAVVATAERGLIVYQLENQPSEFRRIDSPLKHQHRCVAIFKDK 224

  Fly   192 E----GYVMSSIEGRVAVEYLDHDPEVQRRKFAFKCHRNREQNI---EQIYPVNALSFHNVYQTF 249
            :    |:.:.|||||||:.|: :.|...:..|.|||||:...|.   :.||.||.::||.|:.|.
Frog   225 QNKPTGFALGSIEGRVAIHYI-NPPNPAKDNFTFKCHRSNGTNTTAPQDIYAVNGIAFHPVHGTL 288

  Fly   250 ATGGSDGIVNIWDGFNKKRLCQFHEYDTSISTLNFSSDGSALAIGCSY 297
            ||.||||..:.||...:.:|....:.|..||..:|:.:|:..|...||
Frog   289 ATVGSDGRFSFWDKDARTKLKTSEQLDQPISACSFNHNGNIFAYSSSY 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bub3	NP_001287587.1	WD40	<10..296	CDD:225201	101/300 (34%)
		WD40	16..262	CDD:295369	89/260 (34%)
		WD40 repeat	16..53	CDD:293791	12/39 (31%)
		WD40 repeat	59..93	CDD:293791	10/34 (29%)
		WD40 repeat	98..134	CDD:293791	14/37 (38%)
		WD40 repeat	141..175	CDD:293791	9/33 (27%)
		WD40 repeat	182..222	CDD:293791	15/43 (35%)
		WD40 repeat	237..283	CDD:293791	18/45 (40%)
rae1	NP_001017142.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37		0/5 (0%)
		WD 1	37..79		14/41 (34%)
		WD40	40..337	CDD:421866	101/299 (34%)
		WD40 repeat	42..84	CDD:293791	12/41 (29%)
		WD 2	84..114		8/29 (28%)
		WD40 repeat	90..125	CDD:293791	10/34 (29%)
		WD 3	125..157		12/31 (39%)
		WD40 repeat	130..168	CDD:293791	14/38 (37%)
		WD 4	168..206		10/37 (27%)
		WD40 repeat	174..208	CDD:293791	9/33 (27%)
		WD40 repeat	215..258	CDD:293791	15/43 (35%)
		WD 5	215..255		14/40 (35%)
		WD 6	271..301		14/29 (48%)
		WD40 repeat	276..326	CDD:293791	19/49 (39%)
		WD 7	310..346		8/27 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53489
OrthoDB	1	1.010	-	-		D1048963at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.930