DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Bub3 and bub3

DIOPT Version :9

Sequence 1:	NP_001287587.1	Gene:	Bub3 / 43490	FlyBaseID:	FBgn0025457	Length:	326	Species:	Drosophila melanogaster
Sequence 2:	NP_001007498.2	Gene:	bub3 / 493224	XenbaseID:	XB-GENE-955683	Length:	330	Species:	Xenopus tropicalis

Alignment Length:	324	Identity:	201/324 - (62%)
Similarity:	247/324 - (76%)	Gaps:	7/324 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EFKLNNPPEDLISAVKFGPKSNQYMAASSWDGTLRFYDVPANQLRQKFVQDAPLLDCAFMDIVHV 69
            |||||..|||.||||||.|.::|::..||||.::|.||||||.||.|:....|:|||||.|..|.
Frog    12 EFKLNQAPEDGISAVKFSPNTSQFLLVSSWDSSVRLYDVPANTLRLKYQHAGPVLDCAFYDPTHA 76

  Fly    70 VSGSLDNQLRLFDVNTQAESIIGAHEEPIRCVEHAEYVNGILTGSWDNTVKLWDMREKRCVGTFE 134
            .||.||:||::.|:||..||::|:|:.||||||:...||.|:|||||.||||||.|.....|||.
Frog    77 WSGGLDHQLKMHDLNTDGESVVGSHDAPIRCVEYCPEVNVIVTGSWDQTVKLWDPRTPCNAGTFS 141

  Fly   135 QNNGKVYSMSVIDEKIVVATSDRKVLIWDLRKMDSYIMKRESSLKYQTRCIRLFPNKEGYVMSSI 199
            |.: |||::||..::::|.|:.|:||:||||.|.....:|||||||||||||.||||:|||:|||
Frog   142 QPD-KVYTLSVSGDRLIVGTAGRRVLVWDLRNMGYVQQRRESSLKYQTRCIRAFPNKQGYVLSSI 205

  Fly   200 EGRVAVEYLDHDPEVQRRKFAFKCHRNREQNIEQIYPVNALSFHNVYQTFATGGSDGIVNIWDGF 264
            ||||||||||...|||::|:||||||.:|.||||||||||:||||::.|||||||||.|||||.|
Frog   206 EGRVAVEYLDPSLEVQKKKYAFKCHRLKENNIEQIYPVNAVSFHNLHNTFATGGSDGFVNIWDPF 270

  Fly   265 NKKRLCQFHEYDTSISTLNFSSDGSALAIGCSYLDQLPETPATVPHP--AIYIRYPTDQETKQK 326
            |||||||||.|.|||::|.||:|||.|||..||:.::.:    :.||  |||||..||.|||.|
Frog   271 NKKRLCQFHRYPTSIASLAFSNDGSTLAIAASYMYEMDD----IDHPEDAIYIRQVTDAETKPK 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bub3	NP_001287587.1	WD40	<10..296	CDD:225201	181/285 (64%)
		WD40	16..262	CDD:295369	153/245 (62%)
		WD40 repeat	16..53	CDD:293791	22/36 (61%)
		WD40 repeat	59..93	CDD:293791	18/33 (55%)
		WD40 repeat	98..134	CDD:293791	22/35 (63%)
		WD40 repeat	141..175	CDD:293791	13/33 (39%)
		WD40 repeat	182..222	CDD:293791	30/39 (77%)
		WD40 repeat	237..283	CDD:293791	35/45 (78%)
bub3	NP_001007498.2	WD40	20..302	CDD:421866	180/282 (64%)
		WD40 repeat	23..60	CDD:293791	22/36 (61%)
		WD40 repeat	66..100	CDD:293791	18/33 (55%)
		WD40 repeat	105..140	CDD:293791	21/34 (62%)
		WD40 repeat	147..181	CDD:293791	13/33 (39%)
		WD40 repeat	188..228	CDD:293791	30/39 (77%)
		WD40 repeat	243..280	CDD:293791	30/36 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	120	1.000	Domainoid score	I5694
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3470
Inparanoid	1	1.050	405	1.000	Inparanoid score	I1855
OMA	1	1.010	-	-		QHG53489
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003514
OrthoInspector	1	1.000	-	-		oto103285
Panther	1	1.100	-	-	LDO	PTHR10971
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2886
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.070