DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Bub3 and CG12782

DIOPT Version :9

Sequence 1:	NP_001287587.1	Gene:	Bub3 / 43490	FlyBaseID:	FBgn0025457	Length:	326	Species:	Drosophila melanogaster
Sequence 2:	NP_611772.2	Gene:	CG12782 / 37685	FlyBaseID:	FBgn0034838	Length:	336	Species:	Drosophila melanogaster

Alignment Length:	306	Identity:	85/306 - (27%)
Similarity:	142/306 - (46%)	Gaps:	24/306 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EFKLNNPPEDLISAVKFGPKSNQYMA--ASSWDGTLRFYDVPANQLRQKFVQDAPLLDCAFMDIV 67
            :::|.|||.|.|||::|.|:|:.:.|  |.|||.|:|.::|.|::|..|.:..   |:....|:.
  Fly    14 DYELPNPPNDTISALEFSPRSSSWNAICAGSWDNTVRIWEVQADRLVPKVMNS---LEGTPFDVT 75

  Fly    68 HVVSGS------LDNQLRLFDVNTQAESIIGAHEEPIR-CVEHAEYVNGILTGSWDNTVKLWDMR 125
            ...||:      ...|:..:|:.:.....:|.|....| |.....|   :.|.|||.:::.||.|
  Fly    76 WNDSGNKVYLSDSSGQVTEWDLESNQLRKVGLHARAARTCHWVGPY---LATTSWDKSIRFWDPR 137

  Fly   126 EKRCVGTFEQNNGKVYSMSVIDEKIVVATSDRKVLIWDLR--KMDSYIMKRESSLKYQTRCIRLF 188
            ....:...|..: :.|:..|:::..|||..||.:|.:.||  .::...||.......|.|.:.|.
  Fly   138 AAIELTRMELPD-RSYAADVLNDVAVVACGDRSILAYTLRGGPVEQGRMKSPGESNTQVRSVALH 201

  Fly   189 PNKE--GYVMSSIEGRVAVEYLDHDPEVQRRKFAFKCHRNREQNIEQIYPVNALSFHNVYQTFAT 251
            .|::  .::::...|.|..:.:.|    :...|..:|||.....|..:|.||.:..:.|.|..||
  Fly   202 QNRDLTSWLIAKTNGMVFDQSMAH----RTVSFPIRCHRRENSGILDVYAVNEVKVNMVTQHIAT 262

  Fly   252 GGSDGIVNIWDGFNKKRLCQFHEYDTSISTLNFSSDGSALAIGCSY 297
            .||||:...||...:.:|.:...:...|:....|.||...|....|
  Fly   263 VGSDGVFCFWDSQMRSKLLESKVHPQPITKCAISGDGKLFAYALGY 308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bub3	NP_001287587.1	WD40	<10..296	CDD:225201	83/298 (28%)
		WD40	16..262	CDD:295369	71/258 (28%)
		WD40 repeat	16..53	CDD:293791	17/38 (45%)
		WD40 repeat	59..93	CDD:293791	6/39 (15%)
		WD40 repeat	98..134	CDD:293791	10/36 (28%)
		WD40 repeat	141..175	CDD:293791	12/35 (34%)
		WD40 repeat	182..222	CDD:293791	7/41 (17%)
		WD40 repeat	237..283	CDD:293791	14/45 (31%)
CG12782	NP_611772.2	WD40	<19..303	CDD:225201	82/294 (28%)
		WD40	25..303	CDD:295369	78/288 (27%)
		WD40 repeat	26..64	CDD:293791	16/37 (43%)
		WD40 repeat	71..101	CDD:293791	5/29 (17%)
		WD40 repeat	109..146	CDD:293791	10/39 (26%)
		WD40 repeat	195..235	CDD:293791	7/43 (16%)
		WD40 repeat	242..272	CDD:293791	12/29 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447786
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1048963at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10971
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950