DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Bub3 and bub-3

DIOPT Version :9

Sequence 1:	NP_001287587.1	Gene:	Bub3 / 43490	FlyBaseID:	FBgn0025457	Length:	326	Species:	Drosophila melanogaster
Sequence 2:	NP_496879.1	Gene:	bub-3 / 175018	WormBaseID:	WBGene00013209	Length:	343	Species:	Caenorhabditis elegans

Alignment Length:	332	Identity:	146/332 - (43%)
Similarity:	212/332 - (63%)	Gaps:	9/332 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PPEFKLNNPPEDLISAVKFGPKS-NQYMAASSWDGTLRFYDV-PANQLRQK--FVQDAPLLDCAF 63
            |.||::..||...||.|:|..:: ::.:|||.||||.|.|:| ....:.:|  |....|||.|.|
Worm    13 PNEFRVPFPPFVQISKVQFQREAGSRLLAASGWDGTCRVYEVGKLGDISEKLVFTHGKPLLTCTF 77

  Fly    64 MDIVHVVSGSLDNQLRLFDVNTQAESIIGAHEEPIRCVEHAEYVNGILTGSWDNTVKLWDMREKR 128
            .....|..|.:|:.::|.|:.|...:.:|:|...:||:|.....:.|::|.||::|||||.|...
Worm    78 AGYNKVAFGGVDHNVKLADIETGNGTQLGSHALAVRCMEFNPMSSLIVSGGWDSSVKLWDARSYG 142

  Fly   129 CVGTFEQNN--GKVYSMSVIDEKIVVATSDRKVLIWDLRKMDSYIMKRESSLKYQTRCIRLFPNK 191
             .|..|..|  ..||:|.|:...|:|.|.|||:.::|.||:...:..|:|.||||||.::.||..
Worm   143 -NGAIESVNVSSSVYAMDVLKHTILVGTKDRKIFMYDSRKLREPLQVRDSPLKYQTRAVQFFPTG 206

  Fly   192 EGYVMSSIEGRVAVEYLDHD-PEVQRRKFAFKCHRNRE-QNIEQIYPVNALSFHNVYQTFATGGS 254
            |.:|:|||||||||||:|.. .|:.:||:||||||.:: ...|.|:||:.::||..|.||||||:
Worm   207 EAFVVSSIEGRVAVEYVDQSGEEMMKRKYAFKCHREKDTDGTELIHPVHTVAFHPKYGTFATGGA 271

  Fly   255 DGIVNIWDGFNKKRLCQFHEYDTSISTLNFSSDGSALAIGCSYLDQLPETPATVPHPAIYIRYPT 319
            ||||||||.||:||:.|.|:::||||:|:|:.|||.|||..||..:....|:.:|:.:|.||:.|
Worm   272 DGIVNIWDPFNRKRIIQLHKFETSISSLSFNEDGSQLAIATSYQYEKEIDPSPLPNNSITIRHIT 336

  Fly   320 DQETKQK 326
            |.|::.|
Worm   337 DPESRPK 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bub3	NP_001287587.1	WD40	<10..296	CDD:225201	132/293 (45%)
		WD40	16..262	CDD:295369	110/253 (43%)
		WD40 repeat	16..53	CDD:293791	15/40 (38%)
		WD40 repeat	59..93	CDD:293791	9/33 (27%)
		WD40 repeat	98..134	CDD:293791	14/35 (40%)
		WD40 repeat	141..175	CDD:293791	12/33 (36%)
		WD40 repeat	182..222	CDD:293791	22/40 (55%)
		WD40 repeat	237..283	CDD:293791	28/45 (62%)
bub-3	NP_496879.1	WD40	<26..313	CDD:225201	130/287 (45%)
		WD40	37..309	CDD:295369	123/272 (45%)
		WD40 repeat	73..107	CDD:293791	9/33 (27%)
		WD40 repeat	112..148	CDD:293791	14/36 (39%)
		WD40 repeat	156..190	CDD:293791	12/33 (36%)
		WD40 repeat	197..238	CDD:293791	22/40 (55%)
		WD40 repeat	254..288	CDD:293791	22/33 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158924
Domainoid	1	1.000	89	1.000	Domainoid score	I4994
eggNOG	1	0.900	-	-		E1_KOG1036
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	269	1.000	Inparanoid score	I1848
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53489
OrthoDB	1	1.010	-	-		D1048963at2759
OrthoFinder	1	1.000	-	-		FOG0003514
OrthoInspector	1	1.000	-	-		oto17305
orthoMCL	1	0.900	-	-		OOG6_102928
Panther	1	1.100	-	-	LDO	PTHR10971
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4439
SonicParanoid	1	1.000	-	-		X2886
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.800