DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Bub3 and Bub3

DIOPT Version :9

Sequence 1:	NP_001287587.1	Gene:	Bub3 / 43490	FlyBaseID:	FBgn0025457	Length:	326	Species:	Drosophila melanogaster
Sequence 2:	NP_001304279.1	Gene:	Bub3 / 12237	MGIID:	1343463	Length:	326	Species:	Mus musculus

Alignment Length:	322	Identity:	195/322 - (60%)
Similarity:	244/322 - (75%)	Gaps:	3/322 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EFKLNNPPEDLISAVKFGPKSNQYMAASSWDGTLRFYDVPANQLRQKFVQDAPLLDCAFMDIVHV 69
            |||||.||||.||:|||.|.::|::..||||.::|.||||||.:|.|:.....:|||||.|..|.
Mouse     6 EFKLNQPPEDGISSVKFSPNTSQFLLVSSWDTSVRLYDVPANSMRLKYQHTGAVLDCAFYDPTHA 70

  Fly    70 VSGSLDNQLRLFDVNTQAESIIGAHEEPIRCVEHAEYVNGILTGSWDNTVKLWDMREKRCVGTFE 134
            .||.||:||::.|:||..|:::|.|:.||||||:...||.::|||||.||||||.|.....|||.
Mouse    71 WSGGLDHQLKMHDLNTDQENLVGTHDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNAGTFS 135

  Fly   135 QNNGKVYSMSVIDEKIVVATSDRKVLIWDLRKMDSYIMKRESSLKYQTRCIRLFPNKEGYVMSSI 199
            |.. |||::||..::::|.|:.|:||:||||.|.....:|||||||||||||.||||:|||:|||
Mouse   136 QPE-KVYTLSVSGDRLIVGTAGRRVLVWDLRNMGYVQQRRESSLKYQTRCIRAFPNKQGYVLSSI 199

  Fly   200 EGRVAVEYLDHDPEVQRRKFAFKCHRNREQNIEQIYPVNALSFHNVYQTFATGGSDGIVNIWDGF 264
            ||||||||||..||||::|:||||||.:|.||||||||||:||||::.|||||||||.|||||.|
Mouse   200 EGRVAVEYLDPSPEVQKKKYAFKCHRLKENNIEQIYPVNAISFHNIHNTFATGGSDGFVNIWDPF 264

  Fly   265 NKKRLCQFHEYDTSISTLNFSSDGSALAIGCSYLDQLPETPATVPHPAIYIRYPTDQETKQK 326
            |||||||||.|.|||::|.||:||:.|||..||:.::.:|..  |...|:||..||.|||.|
Mouse   265 NKKRLCQFHRYPTSIASLAFSNDGTTLAIASSYMYEMDDTEH--PEDGIFIRQVTDAETKPK 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bub3	NP_001287587.1	WD40	<10..296	CDD:225201	177/285 (62%)
		WD40	16..262	CDD:295369	149/245 (61%)
		WD40 repeat	16..53	CDD:293791	20/36 (56%)
		WD40 repeat	59..93	CDD:293791	17/33 (52%)
		WD40 repeat	98..134	CDD:293791	21/35 (60%)
		WD40 repeat	141..175	CDD:293791	13/33 (39%)
		WD40 repeat	182..222	CDD:293791	31/39 (79%)
		WD40 repeat	237..283	CDD:293791	35/45 (78%)
Bub3	NP_001304279.1	WD 1	5..43		21/36 (58%)
		WD40	14..296	CDD:421866	175/281 (62%)
		WD40 repeat	17..54	CDD:293791	20/36 (56%)
		WD 2	46..83		17/36 (47%)
		WD40 repeat	60..94	CDD:293791	17/33 (52%)
		WD 3	86..124		21/37 (57%)
		WD40 repeat	99..134	CDD:293791	20/34 (59%)
		WD 4	128..163		14/34 (41%)
		WD40 repeat	141..175	CDD:293791	14/33 (42%)
		WD40 repeat	182..222	CDD:293791	31/39 (79%)
		WD 5	223..262		30/38 (79%)
		WD40 repeat	237..274	CDD:293791	30/36 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836453
Domainoid	1	1.000	123	1.000	Domainoid score	I5614
eggNOG	1	0.900	-	-		E1_KOG1036
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3470
Inparanoid	1	1.050	407	1.000	Inparanoid score	I1865
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53489
OrthoDB	1	1.010	-	-		D1048963at2759
OrthoFinder	1	1.000	-	-		FOG0003514
OrthoInspector	1	1.000	-	-		oto93029
orthoMCL	1	0.900	-	-		OOG6_102928
Panther	1	1.100	-	-	LDO	PTHR10971
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4439
SonicParanoid	1	1.000	-	-		X2886
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.800