DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk19 and asic1a

DIOPT Version :9

Sequence 1:	NP_651708.2	Gene:	ppk19 / 43489	FlyBaseID:	FBgn0039679	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	XP_021333995.1	Gene:	asic1a / 791696	ZFINID:	ZDB-GENE-040513-2	Length:	614	Species:	Danio rerio

Alignment Length:	532	Identity:	111/532 - (20%)
Similarity:	199/532 - (37%)	Gaps:	167/532 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 FAH-SNIHGMQHVFGEQHLWQR-CLWLAIVLGAVITGFSLYTVL--MHRHSEQLLVSLIETTQLP 97
            ||| |.:||:.|:|..:.:..: |||:...|.::.  |.:|..:  :..:.|...|:.::....|
Zfish   139 FAHTSTLHGISHIFSYEKITAKCCLWVVFFLSSLT--FLMYVCIDRIQFYLEYPHVTKLDEITTP 201

  Fly    98 VYHIDFPAVAVCPWNHFNWQR--------APSAFIRFLPRHPNAELRETFRQLLASMDIM----N 150
            |  :.||||.:|..|...:.|        |.........||   |:||......:.|:::    :
Zfish   202 V--MVFPAVTICNLNSIRFSRITRNDLYHAGELLALLNSRH---EVREAHLVEESVMEVLKSKTD 261

  Fly   151 FSNFNRIRILTKRNLTGISYLKMTDLMNFMTYRCDELFVADSCVFDET---PYDCCKLFVREQTV 212
            |.:|..            .:..|.:..|...:...::.:  ||.|..:   |.|...:|.|
Zfish   262 FRSFKP------------RHFNMWEFYNRTGHDIKDMLL--SCQFRGSPCRPEDFSVVFTR---- 308

  Fly   213 KGQCLVFNSMISENSRKKHLINQFYPHKLST-AGEDSGLKFTINASY---------SFMNNIDAL 267
            .|:|..|||            .:..|.::|. .|..:||:..::...         |..::.:|
Zfish   309 YGKCYTFNS------------GETGPPRVSVKGGMGNGLEIMLDIQQDEYLPVWGESDESSFEA- 360

  Fly   268 TPFGMNLMI---KEPRQWSNEMMYHLYPDTENFVAVHP--LV---------TETSPNT-----YE 313
               |:.:.|   .|| .:.:::.:.:.|..:.||:...  ||         ..|.|::     |.
Zfish   361 ---GIKVQIHSQDEP-PFIDQLGFGVAPGFQTFVSCQEQRLVYLPAPWGSCKSTPPSSDYFRAYS 421

  Fly   314 MSPKKRRCYFDDEKNPTFQNTSLTYNRENCLVVCLHL---------VVWKTCQCSLPAFLPPIDG 369
            :|..:..|             ...|..|||....:|:         |::|  :|:.||    :|.
Zfish   422 ISACRTDC-------------ETRYLVENCNCRMVHMPGDAPYCTPVLYK--ECAHPA----LDF 467

  Fly   370 VPECGINDAQCLGNNSDIFTYVKMGDQEKYINDSRQGHFCDCPDNCNSRLYEMSLNVRKLDYPKN 434
            :.|          .:||                     :|.|...||...|...|:..|:  |..
Zfish   468 LVE----------TDSD---------------------YCSCETPCNITRYSKELSFVKI--PSK 499

  Fly   435 STDQLI-----KAQVYYGQRVMT--KIITKLKYTNID---------LLANFGGIISLYIGASVMS 483
            ::.:.:     |::.|..:.||.  .....|.|..|:         ||.:.||.:.|:||||:::
Zfish   500 ASVKYLAKKYSKSEKYITENVMVLDVFFEALNYETIEQRKAYEVAGLLGDIGGQMGLFIGASILT 564

  Fly   484 FIELLFVLGKLM 495
            .:||...|.::|
Zfish   565 ILELFDYLYEVM 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk19	NP_651708.2	ASC	39..489	CDD:279230	107/522 (20%)
ppk19	NP_651708.2	AceK	116..>139	CDD:295079	7/30 (23%)
asic1a	XP_021333995.1	ASC	136..582	CDD:322155	111/532 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.020