Protein Alignment ppk19 and SCNN1D

DIOPT Version :9

• Sequence 1: NP_651708.2
• Gene: ppk19 / 43489
• FlyBaseID: FBgn0039679
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_001123885.2
• Gene: SCNN1D / 6339
• HGNCID: 10601
• Length: 802
• Species: Homo sapiens
• Alignment Length: 607
• Identity: 113/607 - (18%)
• Similarity: 201/607 - (33%)
• Gaps: 211/607 - (34%)

  Fly    11 PRPRP--------------GLLRFRNNPRGIKFREKLCNSFAHSNIHG-MQHVFGEQHLWQRCLW 60
            |||.|              ||:..     ...|||.|.....::.||| ::.|....:..:...|
Human   193 PRPGPPSAPPPPPKEGHQEGLVEL-----PASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSW 252

  Fly    61 LAIVLGAVITGFSLYTVLMHRHSEQ---LLVSLIETTQLPVYHIDFPAVAVCPWNHFNWQRAPSA 122
            ..:.|||::.......:|..||..:   :.||:....:|      .|.|.:|..|    .|.||.
Human   253 GLLSLGALVALCWQLGLLFERHWHRPVLMAVSVHSERKL------LPLVTLCDGN----PRRPSP 307

  Fly   123 FIRFLPRHPNAELRETF-RQLLASMDIMNFS------------------------------NFNR 156
            .:|.|      ||.:.| |:.:.|:..:|.|                              :.:|
Human   308 VLRHL------ELLDEFARENIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGSR 366

  Fly   157 IRI------------LTKRNLTGIS------YLKMTDLMNFMTYRCDEL-------FVADSCVFD 196
            :|:            ..:...:|::      :....|::..:....::.       ||. ||.:|
Human   367 VRVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVL-SCSYD 430

  Fly   197 ETPYDCCKLFVREQTVKGQCLVFNSM-ISENSRKKHLIN-----QFYPH--KLSTAGEDSGLKFT 253
            .......:.........|.|...:.: .::.....|.:.     :..||  .|||.   :|::..
Human   431 GLDCQARQFRTFHHPTYGSCYTVDGVWTAQRPGITHGVGLVLRVEQQPHLPLLSTL---AGIRVM 492

  Fly   254 INASYSFMNNIDALTPFGMNLMIKEPRQWSNEMMYHLY---PDTENFVAVHPLVTETSPNTYEMS 315
            ::.    .|:    |||               :.:|.:   |.||..:::.      ....:.:.
Human   493 VHG----RNH----TPF---------------LGHHSFSVRPGTEATISIR------EDEVHRLG 528

  Fly   316 PKKRRCYFDDE--KNPTFQNTSLTYNRENCLVVCLHLVVWKTCQCSLPAFLPPIDGVPECGINDA 378
            .....|....|  :.....|||  |.|:.|||.|...::.:||.|..  :|.|:....|
Human   529 SPYGHCTAGGEGVEVELLHNTS--YTRQACLVSCFQQLMVETCSCGY--YLHPLPAGAE------ 583

  Fly   379 QCLGNNSDIFTYVKMGDQEKYINDSRQ---GHFC-----------------DCPDNCNSRLYEMS 423
                                |.:.:|.   || |                 .||..|....:::|
Human   584 --------------------YCSSARHPAWGH-CFYRLYQDLETHRLPCTSRCPRPCRESAFKLS 627

  Fly   424 LNVRKLDYPKNS-------TDQLIKAQVYYGQRVMTKI---ITKLKYTNID---------LLANF 469
            ....:....|::       .:|.:..|.:..:..:.||   ..:|.|.:::         ||:..
Human   628 TGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAM 692

  Fly   470 GGIISLYIGASVMSFIELLFVL 491
            |.:.||:.||||:|.:|||.:|
Human   693 GSLCSLWFGASVLSLLELLELL 714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk19	NP_651708.2	ASC	39..489	CDD:279230	101/561 (18%)
		AceK	116..>139	CDD:295079	7/22 (32%)
SCNN1D	NP_001123885.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	145..211		4/17 (24%)
		ENaC	219..784	CDD:273304	107/576 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	738..777

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820