Protein Alignment ppk19 and SCNN1B

DIOPT Version :10

• Sequence 1: NP_651708.2
• Gene: ppk19 / 43489
• FlyBaseID: FBgn0039679
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: XP_016879014.1
• Gene: SCNN1B / 6338
• HGNCID: 10600
• Length: 659
• Species: Homo sapiens
• Alignment Length: 617
• Identity: 129/617 - (20%)
• Similarity: 225/617 - (36%)
• Gaps: 187/617 - (30%)

  Fly    16 GLLRFRNNPRGIKFREKLCNSFAHSNIHGMQHVFGEQHLWQRCLW--LAIVLGAVIT---GFSLY 75
            ||.|.:..| |..::|.|.....::|.||.:.:..|... ::.:|  |.::..|::.   |..:.
Human    29 GLHRLQKGP-GYTYKELLVWYCDNTNTHGPKRIICEGPK-KKAMWFLLTLLFAALVCWQWGIFIR 91

  Fly    76 TVLMHRHSEQLLVSLIETTQLPVYHIDFPAVAVC---PW-------------------------- 111
            |.|    |.::.|||    .:....:|||||.:|   |:
Human    92 TYL----SWEVSVSL----SVGFKTMDFPAVTICNASPFKYSKIKHLLKDLDELMEAVLERILAP 148

  Fly   112 --NHFN---------WQRAPSAFI-RFLPRHP--------------NAELRETFRQLLASMDIMN 150
              :|.|         |...|...| ...|.||              ::...|...........|.
Human   149 ELSHANATRNLNFSIWNHTPLVLIDERNPHHPMVLDLFGDNHNGLTSSSASEKICNAHGCKMAMR 213

  Fly   151 FSNFNRIRILTKRNLTGIS-------YLKMTDL--------MNFMTYRCDELFVADSCVFDETPY 200
            ..:.||.: .|.||.|..:       .|:.|::        :..|:|..:::.:|  |:|...|
Human   214 LCSLNRTQ-CTFRNFTSATQALTEWYILQATNIFAQVPQQELVEMSYPGEQMILA--CLFGAEP- 274

  Fly   201 DC-----CKLFVREQTVKGQCLVFNSMISENSRKKHLINQFYPHKLSTAGEDSGLKFTINASYSF 260
             |     ..:|....   |.|.:||..::|.:...           :..|.:.|||..::...
Human   275 -CNYRNFTSIFYPHY---GNCYIFNWGMTEKALPS-----------ANPGTEFGLKLILDIGQ-- 322

  Fly   261 MNNIDALTPF-----GMNLMIKEPRQW---SNEMMYHLYPDTENFVAVHPLVTETSPNTYEMSPK 317
                :...||     |:.||:.|.|.:   .:|.:|.: ..||..:.|  ||.:........||
Human   323 ----EDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAM-SGTETSIGV--LVDKLQRMGEPYSP- 379

  Fly   318 KRRCYFDDEKNPT---FQNTSLTYNRENCLVVCL--HLVVWKTCQCSLPAFLPPID-GVPECGIN 376
               |..:..:.|.   :.:.:.||:.:.||..|.  |::  :.|.|.  .:|.|:. |...|...
Human   380 ---CTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMI--RNCNCG--HYLYPLPRGEKYCNNR 437

  Fly   377 D----AQCLGNNSDIFTYVKMGDQEKYINDSRQGHFCDCPDNCNSRLYEMSLNVRKLDYPKNSTD 437
            |    |.|.   ||:  .:.:..:|..|.        .|.::||...|:|::::  .|:|..:::
Human   438 DFPDWAHCY---SDL--QMSVAQRETCIG--------MCKESCNDTQYKMTISM--ADWPSEASE 487

  Fly   438 Q----------------------LIKAQVYYGQRVMTKIITKLKYTNID-LLANFGGIISLYIGA 479
            .                      ::|..:|: |....:.|.:....||. ||:|.||....::|.
Human   488 DWIFHVLSQERDQSTNITLSRKGIVKLNIYF-QEFNYRTIEESAANNIVWLLSNLGGQFGFWMGG 551

  Fly   480 SVMSFIELLFVLGKLMWGFIRDARIKLKEYTK 511
            ||:..||    .|:::..|:....|||....|
Human   552 SVLCLIE----FGEIIIDFVWITIIKLVALAK 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk19	NP_651708.2	ASC	37..489	CDD:459966	116/572 (20%)
SCNN1B	XP_016879014.1	ENaC	40..642	CDD:273304	124/605 (20%)