Protein Alignment ppk19 and SCNN1A

DIOPT Version :9

• Sequence 1: NP_651708.2
• Gene: ppk19 / 43489
• FlyBaseID: FBgn0039679
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_001153048.1
• Gene: SCNN1A / 6337
• HGNCID: 10599
• Length: 728
• Species: Homo sapiens
• Alignment Length: 603
• Identity: 120/603 - (19%)
• Similarity: 201/603 - (33%)
• Gaps: 192/603 - (31%)

  Fly    17 LLRFRNNPRGIKFREKLCNSFAHSNIHGMQHVFGEQH------LWQRCLWLAIVLGAVITGFSL- 74
            |:.|..:.|  :..|..||   ::.|||...:...||      .| ..|||. ..|.:...|.|
Human   107 LIEFHRSYR--ELFEFFCN---NTTIHGAIRLVCSQHNRMKTAFW-AVLWLC-TFGMMYWQFGLL 164

  Fly    75 ------YTVLM--HRHSEQLLVSLIETTQLPVYHIDFPAVAVCPWNHFNWQRAP----------- 120
                  |.|.:  :.:|::|:               ||||.:|..|.:.:....
Human   165 FGEYFSYPVSLNINLNSDKLV---------------FPAVTICTLNPYRYPEIKEELEELDRITE 214

  Fly   121 ---------SAFIRF-------------LPRHPNAELR--------------------------- 136
                     |:|...             || ||...||
Human   215 QTLFDLYKYSSFTTLVAGSRSRRDLRGTLP-HPLQRLRVPPPPHGARRARSVASSLRDNNPQVDW 278

  Fly   137 ---------------ETFRQLLAS-MD-IMNFSNFNRIRILTKRNLTGISYLKMTDLMNFMTYRC 184
                           :.|.|..:| :| :..:..|:.|.||::...| :..|:...|.||:.
Human   279 KDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPET-LPSLEEDTLGNFIF--- 339

  Fly   185 DELFVADSCVFDETPYDCCKLFVREQTVKGQCLVFNSMISENSRKKHLINQFYPHKLSTAGEDSG 249
                   :|.|::...:..........:.|.|..||...:.|....           |..|.::|
Human   340 -------ACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMS-----------SMPGINNG 386

  Fly   250 LKFTINASYS-FMNNIDALTPFGMNLMI---KEPRQWSNEMMYHLYPDTENFVAVHPLVTETSPN 310
            |...:.|..: |:..:..:|  |..:|:   .|| .:.::..::|.|..|..:::..
Human   387 LSLMLRAEQNDFIPLLSTVT--GARVMVHGQDEP-AFMDDGGFNLRPGVETSISMRK-------- 440

  Fly   311 TYEMSPKKRRCYFDDEKN----PTFQNTSLTYNRENCLVVCLHLVVWKTCQCSLPAFLPPIDGVP 371
              |...:....|.|..||    |........|.::.|:..|....:.|.|.|:. .|.|....|.
Human   441 --ETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAY-IFYPRPQNVE 502

  Fly   372 ECGINDAQCLGNNSDIFTYVKMGDQEKYINDSRQGHFCDCPDNCNSRLYEMSLNVRKLDYPKNST 436
            .|........|     :.|.|:  |..:.:| ..|.|..|...|:...|::|....:  :|..::
Human   503 YCDYRKHSSWG-----YCYYKL--QVDFSSD-HLGCFTKCRKPCSVTSYQLSAGYSR--WPSVTS 557

  Fly   437 D----QLIKAQVYY-------GQRVMTKIITKLKY---------TNIDLLANFGGIISLYIGASV 481
            .    |::..|..|       |...:.....:|.|         |.:.||:|.|...||:.|:||
Human   558 QEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSV 622

  Fly   482 MSFI---ELLFVLGKLMW 496
            :|.:   ||:|.|..:|:
Human   623 LSVVEMAELVFDLLVIMF 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk19	NP_651708.2	ASC	39..489	CDD:279230	111/572 (19%)
		AceK	116..>139	CDD:295079	8/97 (8%)
SCNN1A	NP_001153048.1	ENaC	113..706	CDD:273304	118/597 (20%)
		deg-1	121..631	CDD:273309	111/576 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820