Protein Alignment ppk19 and Asic5

DIOPT Version :10

• Sequence 1: NP_651708.2
• Gene: ppk19 / 43489
• FlyBaseID: FBgn0039679
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_067345.1
• Gene: Asic5 / 58170
• MGIID: 1929259
• Length: 495
• Species: Mus musculus
• Alignment Length: 540
• Identity: 134/540 - (24%)
• Similarity: 225/540 - (41%)
• Gaps: 129/540 - (23%)

  Fly     6 KELVIPRPRPGLLRFRNNPRGIKFREKLCNSFAHS-NIHGMQHVFGEQHLWQRCLWLAIVLGAV- 68
            |..:..||.|       :|..   |:|....||.| :.||:.::...|:..::.:|||:|||:|
Mouse    20 KRYLSKRPLP-------SPTD---RKKFDQDFAMSTSFHGIHNIAQNQNKVRKVIWLAVVLGSVS 74

  Fly    69 ITGFSLYTVLMHRHSEQLLVSLIETTQLPVYH---IDFPAVAVCPWNHFNWQRAPSAF--IRFLP 128
            :..:.:|:.|::      ..:...||.:.|.:   |:||||.:|..|.|..: |.|.|  |.||.
Mouse    75 LLVWQIYSRLVN------YFTWPTTTSIEVQYVEKIEFPAVTLCNLNRFQTE-AVSRFGIIFFLW 132

  Fly   129 RHPNAELRETFRQLLA-------SMD-IMNFSNFNRIRILTKRNLTGISYLKMTDLMNFMTYRCD 185
            ...:..||  .:::.|       ::| :.|..||: |....|.|  |. ||....|::     |:
Mouse   133 DIVSKVLR--LQEISANNTGSPETLDFVTNHQNFS-ITEFVKNN--GF-YLNNDTLVH-----CE 186

  Fly   186 ELFVADSCVFDETPYDCCKLFVREQTVKGQCLVFNSMISENSRKKHLINQFYPHKLSTAGEDSGL 250
              |...:|    :|.|...:|    |..|.|..||  ..||.:.|        :|:|.:|.  ||
Mouse   187 --FFGKTC----SPKDFKHVF----TEYGNCFTFN--YGENIQNK--------NKVSVSGR--GL 229

  Fly   251 KFTINA-SYSFMNN-IDALTPFGMNLMIKEPRQWSNEMMYHLYPDTENF-----VAVHPLVTETS 308
            |..::. ...|.:| :......|:..:|..|::         .|..:..     |.:|..||...
Mouse   230 KLLLDVHQEEFTDNPVPGFADAGVIFVIHSPKK---------EPQFDGLGLSSPVGMHARVTIRQ 285

  Fly   309 PNTYEMSPKKRRCYFDDEKNPTFQ-NTSLTYNRENCLVVCLHLVVWKTCQCSLPAFLPPIDGVPE 372
            ..|....      |...|.||..: ...:||:...||..|....:.:.|.| || ||.|.:|| |
Mouse   286 LKTVHQE------YPWGECNPNIKLRNFITYSTYGCLKECKARHIQRLCGC-LP-FLLPGNGV-E 341

  Fly   373 CGIND-AQCLGNNSDIFTYVKMGDQEKYINDSRQG------HFCDCPDNCNSRLYEMSLN----- 425
            |.:.: ..|:   |.|..:::           |:|      |...||.:|....|..:::
Mouse   342 CDLLEYYNCV---SPILDHIE-----------RKGLCTMGTHNSSCPVSCEETEYPATVSYSTFP 392

  Fly   426 --------VRKLDYPKN-STDQLIKAQVYYGQRVMTKIITKLKYTNI-DLLANFGGIISLYIGAS 480
                    .:||:..:. ..:.|:..::.|.. :..||..:.|..:: :|||:.||.:.|:.|||
Mouse   393 SQRATRFLAKKLNQSQEYIRENLVNIEINYSD-LNYKITQQQKAVSVPELLADVGGQLGLFCGAS 456

  Fly   481 VMSFIELL-FVLGKLMWGFI 499
            :::.||:: :......|..|
Mouse   457 LITIIEIIEYFFTNFYWVLI 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk19	NP_651708.2	ASC	37..489	CDD:459966	125/497 (25%)
Asic5	NP_067345.1	Binds the plasma membrane and stabilizes the channel in the closed state. /evidence=ECO:0000250|UniProtKB:Q9R0W5	1..30		4/16 (25%)
		ASC	41..466	CDD:459966	125/497 (25%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	454..456		1/1 (100%)