DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk19 and ASIC4

DIOPT Version :9

Sequence 1:	NP_651708.2	Gene:	ppk19 / 43489	FlyBaseID:	FBgn0039679	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_061144.4	Gene:	ASIC4 / 55515	HGNCID:	21263	Length:	539	Species:	Homo sapiens

Alignment Length:	497	Identity:	106/497 - (21%)
Similarity:	182/497 - (36%)	Gaps:	115/497 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 SNIHGMQHVFGE-QHLWQRCLWLAIVLGAVITGFSLYTV-------LMHRHSEQLLVSLIETTQL 96
            |.:||:....|. .|..:|.|| |:.|...:..| ||..       |...|    ||::......
Human    49 STLHGLGRACGPGPHGLRRTLW-ALALLTSLAAF-LYQAAGLARGYLTRPH----LVAMDPAAPA 107

  Fly    97 PVYHIDFPAVAVCPWNHFNWQRAPSAFIRFLPRHPNAELRETFRQLLASMDIMNFSNFNRI--RI 159
            ||  ..||||.:|..|.|              ||          ..|:..||.:.:|...:  :.
Human   108 PV--AGFPAVTLCNINRF--------------RH----------SALSDADIFHLANLTGLPPKD 146

  Fly   160 LTKRNLTGISYLK--MTDLMNFMTYRCDELFVADSCVFDETPYDC-CKLFVREQTVKGQCLVFNS 221
            .......|:.|.:  |.|::|...::..::.  .||.|  :.:.| ...|....|..|:|..||:
Human   147 RDGHRAAGLRYPEPDMVDILNRTGHQLADML--KSCNF--SGHHCSASNFSVVYTRYGKCYTFNA 207

  Fly   222 --MISENSRKKHLINQFYPHKLSTAGEDSGLKFTINASYS-----FMNNIDALTPFGMNLMI--K 277
              ..|..||              ..|..|||:..::....     :....:.....|:.:.|  :
Human   208 DPRSSLPSR--------------AGGMGSGLEIMLDIQQEEYLPIWRETNETSFEAGIRVQIHSQ 258

  Fly   278 EPRQWSNEMMYHLYPDTENFVAVHPLVTETSPNTYEMSPKKRRCYFDDE-KNPTFQNTSLTYNRE 341
            |...:.:::.:.:.|..:.||:     .:....||...| ...|..:.| :.|..|..| .|:..
Human   259 EEPPYIHQLGFGVSPGFQTFVS-----CQEQRLTYLPQP-WGNCRAESELREPELQGYS-AYSVS 316

  Fly   342 NCLVVCLHLVVWKTCQCSLPAFLPPIDGVPECGINDAQCLGNNSDIFTYVKMGDQEKYINDSRQG 406
            .|.:.|....|.:.|.|.: ..:|.         |:..|..|     .|::..|   :..||..|
Human   317 ACRLRCEKEAVLQRCHCRM-VHMPG---------NETICPPN-----IYIECAD---HTLDSLGG 363

  Fly   407 ---HFCDCPDNCNSRLYEMSLNVRKL-----------DYPKNST---DQLIKAQVYYGQRVMTKI 454
               ..|.||..||...|...:::.::           .|.:|.|   :..:...|::.......:
Human   364 GPEGPCFCPTPCNLTRYGKEISMVRIPNRGSARYLARKYNRNETYIRENFLVLDVFFEALTSEAM 428

  Fly   455 ITKLKYTNIDLLANFGGIISLYIGASVMSFIELLFVLGKLMW 496
            ..:..|....||.:.||.:.|:||||:::.:|:|..:.::.|
Human   429 EQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVSW 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk19	NP_651708.2	ASC	39..489	CDD:279230	104/488 (21%)
ppk19	NP_651708.2	AceK	116..>139	CDD:295079	2/22 (9%)
ASIC4	NP_061144.4	ASC	40..488	CDD:413546	106/497 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920