Protein Alignment ppk19 and ASIC4

DIOPT Version :10

• Sequence 1: NP_651708.2
• Gene: ppk19 / 43489
• FlyBaseID: FBgn0039679
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: XP_054198812.1
• Gene: ASIC4 / 55515
• HGNCID: 21263
• Length: 666
• Species: Homo sapiens
• Alignment Length: 497
• Identity: 106/497 - (21%)
• Similarity: 182/497 - (36%)
• Gaps: 115/497 - (23%)

  Fly    40 SNIHGMQHVFGE-QHLWQRCLWLAIVLGAVITGFSLYTV-------LMHRHSEQLLVSLIETTQL 96
            |.:||:....|. .|..:|.|| |:.|...:..| ||..       |...|    ||::......
Human   176 STLHGLGRACGPGPHGLRRTLW-ALALLTSLAAF-LYQAAGLARGYLTRPH----LVAMDPAAPA 234

  Fly    97 PVYHIDFPAVAVCPWNHFNWQRAPSAFIRFLPRHPNAELRETFRQLLASMDIMNFSNFNRI--RI 159
            ||  ..||||.:|..|.|              ||          ..|:..||.:.:|...:  :.
Human   235 PV--AGFPAVTLCNINRF--------------RH----------SALSDADIFHLANLTGLPPKD 273

  Fly   160 LTKRNLTGISYLK--MTDLMNFMTYRCDELFVADSCVFDETPYDC-CKLFVREQTVKGQCLVFNS 221
            .......|:.|.:  |.|::|...::..::.  .||.|  :.:.| ...|....|..|:|..||:
Human   274 RDGHRAAGLRYPEPDMVDILNRTGHQLADML--KSCNF--SGHHCSASNFSVVYTRYGKCYTFNA 334

  Fly   222 --MISENSRKKHLINQFYPHKLSTAGEDSGLKFTINASYS-----FMNNIDALTPFGMNLMI--K 277
              ..|..||              ..|..|||:..::....     :....:.....|:.:.|  :
Human   335 DPRSSLPSR--------------AGGMGSGLEIMLDIQQEEYLPIWRETNETSFEAGIRVQIHSQ 385

  Fly   278 EPRQWSNEMMYHLYPDTENFVAVHPLVTETSPNTYEMSPKKRRCYFDDE-KNPTFQNTSLTYNRE 341
            |...:.:::.:.:.|..:.||:     .:....||...| ...|..:.| :.|..|..| .|:..
Human   386 EEPPYIHQLGFGVSPGFQTFVS-----CQEQRLTYLPQP-WGNCRAESELREPELQGYS-AYSVS 443

  Fly   342 NCLVVCLHLVVWKTCQCSLPAFLPPIDGVPECGINDAQCLGNNSDIFTYVKMGDQEKYINDSRQG 406
            .|.:.|....|.:.|.|.: ..:|.         |:..|..|     .|::..|   :..||..|
Human   444 ACRLRCEKEAVLQRCHCRM-VHMPG---------NETICPPN-----IYIECAD---HTLDSLGG 490

  Fly   407 ---HFCDCPDNCNSRLYEMSLNVRKL-----------DYPKNST---DQLIKAQVYYGQRVMTKI 454
               ..|.||..||...|...:::.::           .|.:|.|   :..:...|::.......:
Human   491 GPEGPCFCPTPCNLTRYGKEISMVRIPNRGSARYLARKYNRNETYIRENFLVLDVFFEALTSEAM 555

  Fly   455 ITKLKYTNIDLLANFGGIISLYIGASVMSFIELLFVLGKLMW 496
            ..:..|....||.:.||.:.|:||||:::.:|:|..:.::.|
Human   556 EQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVSW 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk19	NP_651708.2	ASC	37..489	CDD:459966	104/488 (21%)
ASIC4	XP_054198812.1	ENaC	167..615	CDD:273304	106/497 (21%)