Protein Alignment ppk19 and ASIC5

DIOPT Version :10

• Sequence 1: NP_651708.2
• Gene: ppk19 / 43489
• FlyBaseID: FBgn0039679
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_059115.1
• Gene: ASIC5 / 51802
• HGNCID: 17537
• Length: 505
• Species: Homo sapiens
• Alignment Length: 532
• Identity: 128/532 - (24%)
• Similarity: 214/532 - (40%)
• Gaps: 128/532 - (24%)

  Fly    30 REKLCNSFAHS-NIHGMQHVFGEQHLWQRCLWLAIVLGAVITGFSLYTVLMHRHSEQLLVSLIE- 92
            |:|..:.||.| :.||:.::...:...:|.|||.:|||:|    ||.|       .|:.:.|:.
Human    34 RKKFDHDFAISTSFHGIHNIVQNRSKIRRVLWLVVVLGSV----SLVT-------WQIYIRLLNY 87

  Fly    93 -----TTQLPVYHI---DFPAVAVCPWNHFNWQRAPSAFIRFLPRHPNAE---LRETFRQLLASM 146
                 ||.:.|.::   :||||..|..|.|.........:.|...|..::   |:|.......|.
Human    88 FTWPTTTSIEVQYVEKMEFPAVTFCNLNRFQTDAVAKFGVIFFLWHIVSKVLHLQEITANSTGSR 152

  Fly   147 DIMNFS----NFNRIRILTKRNLTGISYLKMTDLMNFMTYRCDELFVADSCVFDETPYDCCKLFV 207
            :..:|:    ||:.:..:..:..    ||..:.|::     |:  |....|    :|.|...:|
Human   153 EATDFAASHQNFSIVEFIRNKGF----YLNNSTLLD-----CE--FFGKPC----SPKDFAHVF- 201

  Fly   208 REQTVKGQCLVFNSMISENSRKKHLINQFYPHKLSTAGEDSGLKFTINASYSFMNN-----IDAL 267
               |..|.|..||.  .|..:.|        .|:|.:|....|.|.:|.. :|.:|     :||
Human   202 ---TEYGNCFTFNH--GETLQAK--------RKVSVSGRGLSLLFNVNQE-AFTDNPALGFVDA- 251

  Fly   268 TPFGMNLMIKEPRQWSNEMMYHLYPDTENF-----VAVHPLVTETSPNTYEMSPKKRRCYFDDEK 327
               |:..:|..|::         .|..:..     |.:|..||.....|....      |...|.
Human   252 ---GIIFVIHSPKK---------VPQFDGLGLLSPVGMHARVTIRQVKTVHQE------YPWGEC 298

  Fly   328 NPT--FQNTSLTYNRENCLVVCLHLVVWKTCQCSLPAFLPPIDGVPECGIND-AQCLGNNSDIFT 389
            ||.  .||.| :|:...||..|....:.|.|.| :| ||.|..|: ||.:.. ..|:   |.:..
Human   299 NPNIKLQNFS-SYSTSGCLKECKAQHIKKQCGC-VP-FLLPGYGI-ECDLQKYFSCV---SPVLD 356

  Fly   390 YVKMGDQEKYINDSRQG-HFCDCPDNCNSRLYEMSLNV------RKLDYPKNSTDQ--------L 439
            :::..|.      ...| |...||.:|....|..:::.      :.|.|.....:|        |
Human   357 HIEFKDL------CTVGTHNSSCPVSCEEIEYPATISYSSFPSQKALKYLSKKLNQSRKYIRENL 415

  Fly   440 IKAQVYYGQRVMTKIITKLKYTNI-DLLANFGGIISLYIGASVMSFIELL-FVLGKLMW---GFI 499
            :|.::.|.. :..||..:.|..:: :|||:.||.:.|:.|||:::.||:: ::.....|   .|:
Human   416 VKIEINYSD-LNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYLFTNFYWICIFFL 479

  Fly   500 RDARIKLKEYTK 511
                :|:.|.|:
Human   480 ----LKISEMTQ 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk19	NP_651708.2	ASC	37..489	CDD:459966	121/498 (24%)
ASIC5	NP_059115.1	Binds the plasma membrane and stabilizes the channel in the closed state. /evidence=ECO:0000250|UniProtKB:Q9R0W5	1..30
		ASC	41..466	CDD:459966	121/498 (24%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	454..456		1/1 (100%)