Protein Alignment ppk19 and ASIC1

DIOPT Version :9

• Sequence 1: NP_651708.2
• Gene: ppk19 / 43489
• FlyBaseID: FBgn0039679
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_064423.2
• Gene: ASIC1 / 41
• HGNCID: 100
• Length: 574
• Species: Homo sapiens
• Alignment Length: 555
• Identity: 100/555 - (18%)
• Similarity: 182/555 - (32%)
• Gaps: 178/555 - (32%)

  Fly    36 SFAHSN-IHGMQHVFGEQHL-WQRCLWLAIVLGAVITGFSLYT----VLMHRHSEQLLVSLIETT 94
            :||.|: :||:.|:|..:.| .:|.||....||::.....:.|    ...|.|      .:.:..
Human    20 AFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYH------HVTKLD 78

  Fly    95 QLPVYHIDFPAVAVCPWNHFNWQRAPS----------AFIRFLPRHPNAELRETFRQLLASMDIM 149
            ::....:.||||.:|..|.|.:.:...          |.:......|:.::.:. :||....|..
Human    79 EVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNNRYEIPDTQMADE-KQLEILQDKA 142

  Fly   150 NFSNFNRIRILTKRNLTGISYLKMTDLMNFMTYRCDELFVADSCVFDETPYDCCKLFVREQTVKG 214
            ||.:| :.:....|.....:...:.|::....:|.:.....|..|          :|.|    .|
Human   143 NFRSF-KPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCSAEDFKV----------VFTR----YG 192

  Fly   215 QCLVFNSMISENSRKKHLINQFYPHKLSTAGEDSGLKFTINASYSFMNNIDALTPF--------- 270
            :|..|||......|.|.:          ..|..:||:..::...      |...|.
Human   193 KCYTFNSGRDGRPRLKTM----------KGGTGNGLEIMLDIQQ------DEYLPVWGETDETSF 241

  Fly   271 --GMNLMI---KEPRQWSNEMMYHLYPDTENFVAVHPLVTETSPNTYEMSPKKRRC--------- 321
              |:.:.|   .|| .:.:::.:.:.|..:.|||..      ......:.|....|
Human   242 EAGIKVQIHSQDEP-PFIDQLGFGVAPGFQTFVACQ------EQRLIYLPPPWGTCKAVTMDSDL 299

  Fly   322 -YFDDEKNPTFQNTSLTYNRENCLVVCLHLVVWKTCQCSLPAFLPPIDGVPECGIND-AQCLGNN 384
             :||            :|:...|.:.|....:.:.|.|.: ..:|  ...|.|.... .:|....
Human   300 DFFD------------SYSITACRIDCETRYLVENCNCRM-VHMP--GDAPYCTPEQYKECADPA 349

  Fly   385 SDIFTYVKMGDQEKYINDSRQGHFCDCPDNCNSRLYEMSLNVRKLDYPKNSTDQLI-----KAQV 444
            .|   ::...|||          :|.|...||...|...|::.|:  |..::.:.:     |::.
Human   350 LD---FLVEKDQE----------YCVCEMPCNLTRYGKELSMVKI--PSKASAKYLAKKFNKSEQ 399

  Fly   445 YYGQRVMTKII--TKLKYTNID------------------------------------------- 464
            |.|:.::...|  ..|.|..|:
Human   400 YIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGELLMTPVPFSCHGHGVAPYHPKAGCSLLSHE 464

  Fly   465 ------------LLANFGGIISLYIGASVMSFIEL 487
                        .|.:.||.:.|:||||:::.:||
Human   465 GPPPQRPFPKPCCLGDIGGQMGLFIGASILTVLEL 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk19	NP_651708.2	ASC	39..489	CDD:279230	98/552 (18%)
		AceK	116..>139	CDD:295079	2/32 (6%)
ASIC1	NP_064423.2	ENaC	19..556	CDD:273304	100/555 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920