DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk19 and asic1b

DIOPT Version :9

Sequence 1:	NP_651708.2	Gene:	ppk19 / 43489	FlyBaseID:	FBgn0039679	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_999956.1	Gene:	asic1b / 407672	ZFINID:	ZDB-GENE-040513-1	Length:	557	Species:	Danio rerio

Alignment Length:	519	Identity:	110/519 - (21%)
Similarity:	178/519 - (34%)	Gaps:	162/519 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LCNSFAHSNIHGMQHVFGE-------QHLWQRCLWLAI------VLGAVI--TGFSLYTVLMHRH 82
            |...|...::||..|||.|       |.||.....|||      |:..||  ..:...|:|..|:
Zfish    66 LATFFGGCSLHGANHVFVEDKKFSIRQGLWALVFLLAISMFLLQVVDRVIYYLQYDYVTLLDERN 130

  Fly    83 SEQLLVSLIETTQLPVYHIDFPAVAVCPWNHFNWQRAPSAFIRF--------------LPRHPNA 133
            ::               ::.|||:.:|.:|.|...:...:.:.|              :|..|..
Zfish   131 AK---------------NMTFPAITLCNYNTFRRSQLSYSDLLFMGPLLGYEDNMAPGIPLAPEP 180

  Fly   134 ELRETFRQLLASMDIMNFSNFNRIRILTKRNLTGISYLKMTDLM---NFMTYRCD-----ELFVA 190
            : |:..|..||..       |||.|            .:|.|::   ||....|.     |:|
Zfish   181 D-RQGSRFSLAEF-------FNRTR------------HRMDDMLLECNFAGKECGAEHWREIF-- 223

  Fly   191 DSCVFDETPYDCCKLFVREQTVKGQCLVFNSMISENSRKKHLINQFYPHKLST-AGEDSGLKFTI 254
                   |.|             |:|..|||  .::.|         |..::| .|..:||:..:
Zfish   224 -------TRY-------------GKCYTFNS--GQDGR---------PLLITTKGGMGNGLEIML 257

  Fly   255 NASYS----FMNNIDALT-PFGMNLMI---KEPRQWSNEMMYHLYPDTENFVAVHPLVTETSPNT 311
            :....    .....|..| ..|:.:.|   .|| .:.:::.:.:.|..:.||:     .:....|
Zfish   258 DIQQDEYLPVWGETDETTFEAGIKVQIHTQDEP-PFIDQLGFGVAPGFQTFVS-----CQEQRLT 316

  Fly   312 YEMSPKKRRCYFDDEKNPTFQNTSLTYNRENCLVVCLHLVVWKTCQCSLPAFLPPIDGVPECGIN 376
            |...|     :.|.:..|...:...||:...|.:.|....:.:.|.|.: ..:|  ...|.|...
Zfish   317 YLPPP-----WGDCKATPIDSDFFNTYSITACRIDCETRYLVENCNCRM-VHMP--GDAPYCTPE 373

  Fly   377 DAQCLGNNSDIFTYVKMGDQEKYINDSRQGHFCDCPDNCNSRLY--EMSL-------NVRKLDYP 432
            .            |.:..|........|...:|.|...||...|  |:|.       :.:.|...
Zfish   374 Q------------YKECADPALDFLVERDNDYCVCETPCNMTRYGKELSFVRIPSKASAKYLAKK 426

  Fly   433 KNSTDQLIKAQVYYGQRVMTKIITKLKYTNID---------LLANFGGIISLYIGASVMSFIEL 487
            .|.|:|.|...:    .|:......|.|..|:         ||.:.||.:.|:||||:::.:||
Zfish   427 YNKTEQYISDNI----MVLDIFFEALNYETIEQKKAYELAGLLGDIGGQMGLFIGASILTILEL 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk19	NP_651708.2	ASC	39..489	CDD:279230	108/513 (21%)
ppk19	NP_651708.2	AceK	116..>139	CDD:295079	4/36 (11%)
asic1b	NP_999956.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..57
		ASC	66..548	CDD:295594	110/519 (21%)
		Selectivity filter. /evidence=ECO:0000305	477..479		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.020