DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk19 and asic4a

DIOPT Version :9

Sequence 1:	NP_651708.2	Gene:	ppk19 / 43489	FlyBaseID:	FBgn0039679	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_999952.1	Gene:	asic4a / 407668	ZFINID:	ZDB-GENE-040513-5	Length:	539	Species:	Danio rerio

Alignment Length:	488	Identity:	103/488 - (21%)
Similarity:	172/488 - (35%)	Gaps:	118/488 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 SNIHGMQHVF------GEQHLWQRCLWLAIVLGAVITGFSLYTVLMHRHSEQLLVSLIETTQLPV 98
            |::||:.|:|      ..|.||.....:::.|..........:.|.|.|     |:.:.....|
Zfish    48 SSLHGINHIFVSGRLGVRQTLWALAFLVSLALFLYQAAKCAISYLEHPH-----VTALNEEATP- 106

  Fly    99 YHIDFPAVAVCPWNHFNWQRAPSAFIRFLPRHPNAELRETFRQLLASMDIMNFSNFNRIRILTK- 162
             .:.||||.:|..|.|          ||              ..|...||.:.:|...:....|
Zfish   107 -EMVFPAVTICNINRF----------RF--------------SALTDADIYHLANLTGLPPKNKD 146

  Fly   163 -RNLTGISY--LKMTDLMNFMTYRCDELFVADSCVFDETPYDC-CKLFVREQTVKGQCLVFNSMI 223
             ...|.:.|  ..|.|:.|...::.:|:.  .||.|  :..:| .:.|....|..|:|..||.
Zfish   147 GHKPTDLEYPAPDMQDIFNRTGHQLEEML--KSCNF--SGQNCSAEDFTVVYTRYGKCYTFNG-- 205

  Fly   224 SENSRKKHLINQFYPHKLSTAGEDSGLKFTINASYSFMNNIDALTPFGMNLMIKEPRQWSNE--M 286
                      |:....|....|..:||:..::...      |...|     :.||..:.|.|  :
Zfish   206 ----------NKTTSRKTKQGGMGNGLEIMLDIQQ------DDYLP-----IWKETNETSLEAGI 249

  Fly   287 MYHLYPDTENFVAVHPLVTETSP--NTYEMSPKKRRCYF----------DDEKNPTFQNTSLTYN 339
            ...::...|. ..:|.|....||  .|:....::|..|.          .::..|.:.    ||:
Zfish   250 RVQIHSQDEP-PYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGNCRSTSEQMIPGYD----TYS 309

  Fly   340 RENCLVVCLHLVVWKTCQCSLPAFLPPIDGVPECGINDAQCLGNNSDIFTYVKMGDQEKYINDSR 404
            ...|.:.|..|.|.:.|:|.: ..:|....:  |..:|.:|:             |:...:....
Zfish   310 ISACRLRCETLEVLRECKCRM-VHMPGDANI--CTPSDIKCV-------------DKALALLQKS 358

  Fly   405 QGHFCDCPDNCNSRLYEMSLNVRKL-----------DYPKNS---TDQLIKAQVYYGQRVMTKII 455
            .|..|.|...||...|...|::.|:           .|.|:.   .|..:...:::.......|.
Zfish   359 SGDTCFCETPCNLTRYGKELSMVKIPSKGSARYLSRKYDKSEDYIRDNFLVLDIFFEALNYETIE 423

  Fly   456 TKLKYTNIDLLANFGGIISLYIGASVMSFIELL 488
            .|..|....||.:.||.:.|:|||||::.:|:|
Zfish   424 QKKAYDVAGLLGDIGGQMGLFIGASVLTILEIL 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk19	NP_651708.2	ASC	39..489	CDD:279230	103/488 (21%)
ppk19	NP_651708.2	AceK	116..>139	CDD:295079	2/22 (9%)
asic4a	NP_999952.1	ASC	44..472	CDD:295594	103/488 (21%)
asic4a	NP_999952.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	474..494
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920