Protein Alignment ppk19 and scnn1a

DIOPT Version :10

• Sequence 1: NP_651708.2
• Gene: ppk19 / 43489
• FlyBaseID: FBgn0039679
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_001184124.1
• Gene: scnn1a / 395013
• XenbaseID: XB-GENE-996083
• Length: 633
• Species: Xenopus tropicalis
• Alignment Length: 574
• Identity: 117/574 - (20%)
• Similarity: 215/574 - (37%)
• Gaps: 137/574 - (23%)

  Fly     5 TKELVIPRPRPGLLRFRNNPRGIKFREKLCNSFAHSNIHG-MQHVFGEQHLWQRCLWLAIVLGAV 68
            :||  :...:..|:.|.::.|  :..|..|   :::.||| ::.|....:..:...||.:.|...
 Frog     2 SKE--VKNEKEPLIEFFSSYR--ELFEFFC---SNTTIHGAIRLVCSRSNRMKTAFWLVLFLATF 59

  Fly    69 ITGFSLYTVLMHRH-SEQLLVSL-IETTQLPVYHIDFPAVAVCPWNHFNWQRAPSAFIRFLPRHP 131
            ...:..:.:|..:: |..:.::| :.:.:||     ||||.||..|.:.: :|....::.|.:..
 Frog    60 GLMYWQFGLLFGQYFSYPVSINLNVNSDKLP-----FPAVTVCTLNPYRY-KAIQNDLQELDKET 118

  Fly   132 NAELRETFRQLLASMDIMNFSNFN-RIRILTKRNLTGISYLKMTDLMNFMTYRCDELFVADSC-- 193
            ...|.|.::  ..|..:..:...| |:|    |:..|:.:|.........|:|.....:.:..
 Frog   119 QRTLYELYK--YNSTGVQGWIPTNQRVR----RDRPGLPHLLELVPPGSKTHRVSRSVIEEELQV 177

  Fly   194 ----------VFDETPYDC--------------------CKLFVR---EQTVKGQCL---VFNSM 222
                      :.:||..||                    ..:..|   |..:.|:.|   :|...
 Frog   178 KRREWNIGFKLCNETGGDCFYQTYTSGVDAIREWYRFHYINILARVPEEAAIDGEQLENFIFACR 242

  Fly   223 ISENSRKKHLINQFYPHKLSTAGEDSGLKFTINASYSFMNNI---------DALT---------- 268
            .:|.|..|...:.|: |.:      .|..:|.|.:.|..:|:         :.||
 Frog   243 FNEESCTKANYSHFH-HAI------YGNCYTFNQNRSGQSNLWSSSMPGIKNGLTLILRTEQHDY 300

  Fly   269 -PF-----GMNLMI---KEPRQWSNEMMYHLYPDTENFVAVHPLVTETSPNTYEMSPKKRRCYFD 324
             |.     |..:::   ||| .:.::..:::.|..|..:.   :..||   ...|..|...|..|
 Frog   301 IPLLSSVAGARVLVHGHKEP-AFMDDSGFNIPPGMETSIG---MKKET---VNRMGGKYSDCSED 358

  Fly   325 ----DEKNPTFQNTSLTYNRENCLVVCLHLVVWKTCQCSLPAFLPPIDGVPECGINDAQCLGNNS 385
                |.|| .|::   .|..:.|:..|....:.:.|.|.. ||.|...|...|..|..:..|:
 Frog   359 GSDVDVKN-LFES---EYTEQVCVRSCFQAAMVERCGCGY-AFYPLSPGDEFCDYNKHKSWGH-- 416

  Fly   386 DIFTYVKMGDQEKYINDSRQGHFCDCPDNCNSRLYEMSLNVRK-------------LDYPKNSTD 437
               .|.|:..:   ...::.|.|..|...|....|:::....|             |....|.||
 Frog   417 ---CYYKLIIE---FTSNKLGCFSKCRKPCLVSEYQLTAGYSKWPNRVSQDWVFHTLSRQYNLTD 475

  Fly   438 Q--LIKAQVYYGQRVMTKIITKLKYTN-IDLLANFGGIISLYIGASVMSFIELL 488
            :  :.|..:|: :.:..|.|.:....| :.||:..|...||:.|:||:|.:|:|
 Frog   476 RNGIAKLNIYF-EELNYKTIQESPTINMVMLLSLLGSQWSLWFGSSVLSVVEML 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk19	NP_651708.2	ASC	37..489	CDD:459966	110/542 (20%)
scnn1a	NP_001184124.1	ENaC	18..602	CDD:273304	113/556 (20%)