DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk19 and Scnn1g

DIOPT Version :9

Sequence 1:	NP_651708.2	Gene:	ppk19 / 43489	FlyBaseID:	FBgn0039679	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_058742.2	Gene:	Scnn1g / 24768	RGDID:	3641	Length:	650	Species:	Rattus norvegicus

Alignment Length:	605	Identity:	118/605 - (19%)
Similarity:	208/605 - (34%)	Gaps:	209/605 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 HSNIHGMQHVFGEQHLWQRCLWLAIVLGAV--------ITGFSLYTVLMHRHSEQLLVSLIETTQ 95
            ::|.||.:.:...:...:|.||:|..|.||        :..||.|||.:             :.:
  Rat    35 NTNTHGCRRIVVSRGRLRRLLWIAFTLTAVALIIWQCALLVFSFYTVSV-------------SIK 86

  Fly    96 LPVYHIDFPAVAVCPWNHFNW----------------------------------------QRAP 120
            :....:|||||.:|..|.:.:                                        :..|
  Rat    87 VHFQKLDFPAVTICNINPYKYSAVSDLLTDLDSETKQALLSLYGVKESRKRREAGSMPSTLEGTP 151

  Fly   121 SAFIRFLP-----RHPNAELRETF--RQLLASMDIMNFSNFNRIRILTKRNLTGI---------- 168
            ..|.:.:|     .:...:.|:.|  |:...|..|::.:: |.:.:...:.|.|.
  Rat   152 PRFFKLIPLLVFNENEKGKARDFFTGRKRKISGKIIHKAS-NVMHVHESKKLVGFQLCSNDTSDC 215

  Fly   169 -------------SYLKMTDLMNF-----------MTYRCDELFVADSCVFDETPYDCCKLFVRE 209
                         .:.|: ..||.           |:|...||.|  :|.||....|.....:..
  Rat   216 ATYTFSSGINAIQEWYKL-HYMNIMAQVPLEKKINMSYSAKELLV--TCFFDGMSCDARNFTLFH 277

  Fly   210 QTVKGQCLVFNSMISENSRKKHLINQFYPHKLSTA--GEDSGLKFTINASYSFMNNIDALTPF-- 270
            ..:.|.|..||:  .||:.           .|||:  |.:.||:..:     ::|. |...||
  Rat   278 HPMYGNCYTFNN--KENAT-----------ILSTSMGGSEYGLQVIL-----YINE-DEYNPFLV 323

  Fly   271 ---GMNLMIKEPRQWSNEMMYHLYPDTENFVAVHPLVTETSPNT---------YEMSPKKRRCYF 323
               |..::|.:    .||     ||    |:....:..||:.:|         :::|....:|..
  Rat   324 SSTGAKVLIHQ----QNE-----YP----FIEDVGMEIETAMSTSIGMHLTESFKLSEPYSQCTE 375

  Fly   324 DDEKNPTFQNTSLTYNRENCLVVCLHLVVWKTCQC---SLPAFLPPIDGVPECGI----NDAQCL 381
            |....|.....:..|:.:.||..|....:.:.|.|   |.|  |||  ....|..    |...|.
  Rat   376 DGSDVPVTNIYNAAYSLQICLYSCFQTKMVEKCGCAQYSQP--LPP--AANYCNYQQHPNWMYCY 436

  Fly   382 GNNSDIFTYVKMGDQEKYINDSRQGHFCDCPDNCNSRLYEMS---------------LNV----- 426
            ......|...::|.|..            |..:|:.:.:.::               |||
  Rat   437 YQLYQAFVREELGCQSV------------CKQSCSFKEWTLTTSLAQWPSEASEKWLLNVLTWDQ 489

  Fly   427 -RKLDYPKNSTDQLIKAQVYYGQRVMTKIITKLKYTNID-LLANFGGIISLYIGASVMS------ 483
             ::::...|.|| |.|..::| :.:..:.|.:....:|: ||:||||.:.|::..||:.
  Rat   490 SQQINKKLNKTD-LAKLLIFY-KDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIE 552

  Fly   484 --FIELLFVLGKLMWGFIRD 501
              ||:...::.:..|...:|
  Rat   553 VFFIDFFSIIARRQWHKAKD 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk19	NP_651708.2	ASC	39..489	CDD:279230	116/591 (20%)
ppk19	NP_651708.2	AceK	116..>139	CDD:295079	4/67 (6%)
Scnn1g	NP_058742.2	ENaC	24..631	CDD:273304	118/605 (20%)
Scnn1g	NP_058742.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..628
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820