DRSC/TRiP Functional Genomics Resources

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Protein Alignment ppk19 and Scnn1g

DIOPT Version :10

Sequence 1:NP_651708.2 Gene:ppk19 / 43489 FlyBaseID:FBgn0039679 Length:511 Species:Drosophila melanogaster
Sequence 2:NP_035456.1 Gene:Scnn1g / 20278 MGIID:104695 Length:655 Species:Mus musculus


Alignment Length:612 Identity:118/612 - (19%)
Similarity:210/612 - (34%) Gaps:218/612 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    39 HSNIHGMQHVFGEQHLWQRCLWLAIVLGAV--------ITGFSLYTVLMHRHSEQLLVSLIETTQ 95
            ::|.||.:.:...:...:|.||:|..|.||        :..||.|||.:             :.:
Mouse    35 NTNTHGCRRIVVSRGRLRRLLWIAFTLTAVALIIWQCALLVFSFYTVSV-------------SIK 86

  Fly    96 LPVYHIDFPAVAVCPWNHF---------------------------------------------N 115
            :....:|||||.:|..|.:                                             .
Mouse    87 VHFQKLDFPAVTICNINPYKYSAVSDLLTDLDSETKQALLSLYGVKDVLDSTPRKRREAGSMRST 151

  Fly   116 WQRAPSAFIRFLP-----RHPNAELRETF--RQLLASMDIMNFSNFNRIRILTKRNLTGI----- 168
            |:..|..|:..:|     .:...:.|:.|  |:...|..|::.:: |.:.:...:.|.|.     
Mouse   152 WEGTPPRFLNLIPLLVFNENEKGKARDFFTGRKRKISGKIIHKAS-NVMHVHESKKLVGFQLCSN 215

  Fly   169 ------------------SYLKMTDLMNF-----------MTYRCDELFVADSCVFDETPYDCCK 204
                              .:.|: ..||.           |:|..:||.|  :|.||....|...
Mouse   216 DTSDCATYTFSSGINAIQEWYKL-HYMNIMAQVPLEKKINMSYSAEELLV--TCFFDGMSCDARN 277

  Fly   205 LFVREQTVKGQCLVFNSMISENSRKKHLINQFYPHKLSTA--GEDSGLKFTINASYSFMNNIDAL 267
            ..:....:.|.|..||:  .||:.           .|||:  |.:.||:..:     ::|. |..
Mouse   278 FTLFHHPMYGNCYTFNN--RENAT-----------ILSTSMGGSEYGLQVIL-----YINE-DEY 323

  Fly   268 TPF-----GMNLMIKEPRQWSNEMMYHLYPDTENF-----------VAVHPLVTETSPNTYEMSP 316
            .||     |..:::.:    .||     ||..|:.           :.:|  :||    ::::|.
Mouse   324 NPFLVSSTGAKVLVHQ----QNE-----YPFIEDVGTEIETAMSTSIGMH--LTE----SFKLSE 373

  Fly   317 KKRRCYFDDEKNPTFQNTSLTYNRENCLVVCLHLVVWKTCQC---SLPAFLPPIDGVPECGI--- 375
            ...:|..|....|.....:..|:.:.||..|....:.:.|.|   |.|  |||  ....|..   
Mouse   374 PYSQCTEDGSDVPVTNIYNAAYSLQICLYSCFQTKMVEKCGCAQYSQP--LPP--AANYCNYQQH 434

  Fly   376 -NDAQCLGNNSDIFTYVKMGDQEKYINDSRQGHFCDCPDNCNSRLYEMS---------------L 424
             |...|.......|...::|.|..            |..:|:.:.:.::               |
Mouse   435 PNWMYCYYQLYQAFVREELGCQSV------------CKQSCSFKEWTLTTSLAQWPSEASEKWLL 487

  Fly   425 NV------RKLDYPKNSTDQLIKAQVYYGQRVMTKIITKLKYTNID-LLANFGGIISLYIGASVM 482
            ||      ::::...|.|| |.|..::| :.:..:.|.:....:|: ||:||||.:.|::..||:
Mouse   488 NVLTWDQSQQINKKLNKTD-LAKLLIFY-KDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVV 550

  Fly   483 S--------FIELLFVLGKLMWGFIRD 501
            .        ||:...::.:..|...:|
Mouse   551 CVIEIIEVFFIDFFSIIARRQWQKAKD 577

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ppk19NP_651708.2 ASC 37..489 CDD:459966 116/598 (19%)
Scnn1gNP_035456.1 ENaC 24..636 CDD:273304 118/612 (19%)
Gating release of inhibition by proteolysis (GRIP), protease-sensitive region that is responsible for the proteolytic activation of the channel. /evidence=ECO:0000305|PubMed:15007080, ECO:0000305|PubMed:18650438 140..227 12/87 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 582..636
PY motif, recruits WW domain-containing proteins and is thereby required for ubiquitination and inhibition of the channel by NEDD4 and NEDD4L. /evidence=ECO:0000250|UniProtKB:P51170 629..633
Blue background indicates that the domain is not in the aligned region.

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