DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ppk19 and Scnn1b

DIOPT Version :10

Sequence 1:NP_651708.2 Gene:ppk19 / 43489 FlyBaseID:FBgn0039679 Length:511 Species:Drosophila melanogaster
Sequence 2:NP_035455.1 Gene:Scnn1b / 20277 MGIID:104696 Length:638 Species:Mus musculus


Alignment Length:619 Identity:133/619 - (21%)
Similarity:217/619 - (35%) Gaps:205/619 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 LLRFRNNPRGIKFREKL---CNSFAHSNIHGMQHVFGEQHLWQRCLW--LAIVLGAVIT---GFS 73
            |.|.:..| |..::|.|   ||   ::|.||.:.:..|... ::.:|  |.::...::.   |..
Mouse    11 LHRLQKGP-GYTYKELLVWYCN---NTNTHGPKRIICEGPK-KKAMWFLLTLLFACLVCWQWGVF 70

  Fly    74 LYTVLMHRHSEQLLVSLIETTQLPVYHIDFPAVAVC---PW------------------------ 111
            :.|.|    |.::.|||    .:....::||||.||   |:                        
Mouse    71 IQTYL----SWEVSVSL----SMGFKTMNFPAVTVCNSSPFQYSKVKHLLKDLDELMEAVLEKIL 127

  Fly   112 ----NHFN---------WQRAPSAFI-RFLPRHP---------------------NAE-LRETFR 140
                :|.|         |...|...| ...|.||                     ||: .:...|
Mouse   128 APEASHSNTTRTLNFTIWNHTPLVLIDERNPDHPVVLNLFGDSHNSSNPAPGSTCNAQGCKVAMR 192

  Fly   141 QLLASMDIMNFSNFNRIR-------ILTKRNLTGISYLKMTDLMNFMTYRCDELFVADSCVFDET 198
            ...|:..:....||....       ||...|:  .|.:...||:. |.|..|.:.:|  |:|...
Mouse   193 LCSANGTVCTLRNFTSATQAVTEWYILQATNI--FSQVLPQDLVG-MGYAPDRIILA--CLFGTE 252

  Fly   199 PYDCCK------LFVREQTVKGQCLVFNSMISENSRKKHLINQFYPHKLSTAGEDSGLKFTINAS 257
            |   |.      :|..:.   |.|.:||..::|.:...           :..|.:.|||..::..
Mouse   253 P---CSHRNFTPIFYPDY---GNCYIFNWGMTEETLPS-----------ANPGTEFGLKLILDIG 300

  Fly   258 YSFMNNIDALTPF-----GMNLMIKEPRQW---SNEMMYHLYPDTENFVAVHPLVTETSPNTYEM 314
            .      :...||     |..||:.|.|.:   ..|.:|.: ..||..:.|  ||.:........
Mouse   301 Q------EDYVPFLASTAGARLMLHEQRTYPFIREEGIYAM-AGTETSIGV--LVDKLQRKGEPY 356

  Fly   315 SPKKRRCYFDDEKNPTFQNTSLTYNRENCLVVCLHLVVWKTC-------QCSLPAFLPPIDGVPE 372
            ||    |..:. .:...:|....||....:..|||     :|       .||...:|.|:   ||
Mouse   357 SP----CTMNG-SDVAIKNLYSVYNTTYSIQACLH-----SCFQDHMIRNCSCGHYLYPL---PE 408

  Fly   373 CGINDAQCLGNNSDI--FTYVKMGDQEKYIN-----DSRQGHFCDCPDNCNSRLYEMSLNVRKLD 430
               .:..|  ||.|.  :.|.       |:|     ..|:.....|.::||...|:|::::  .|
Mouse   409 ---GEKYC--NNRDFPDWAYC-------YLNLQMSVTQRETCLSMCKESCNDTQYKMTISM--AD 459

  Fly   431 YPKNSTDQ----------------------LIKAQVYYGQRVMTKIITKLKYTNID-LLANFGGI 472
            :|..:::.                      ::|..:|: |....:.|.:....||. ||:|.||.
Mouse   460 WPSEASEDWILHVLSQERDQSSNITLSRKGIVKLNIYF-QEFNYRTIEESPANNIVWLLSNLGGQ 523

  Fly   473 ISLYIGASVMSFIELLFVLGKLMWGFIRDARIKL 506
            ...::|.||:..||    .|:::..||....|||
Mouse   524 FGFWMGGSVLCLIE----FGEIIIDFIWITIIKL 553

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ppk19NP_651708.2 ASC 37..489 CDD:459966 119/577 (21%)
Scnn1bNP_035455.1 ENaC 21..621 CDD:273304 129/608 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 594..620
PY motif, recruits WW domain-containing proteins and is thereby required for ubiquitination and inhibition of the channel by NEDD4 and NEDD4L. /evidence=ECO:0000250|UniProtKB:P51168 614..618
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.