Protein Alignment ppk19 and Scnn1a

DIOPT Version :10

• Sequence 1: NP_651708.2
• Gene: ppk19 / 43489
• FlyBaseID: FBgn0039679
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_035454.3
• Gene: Scnn1a / 20276
• MGIID: 101782
• Length: 699
• Species: Mus musculus
• Alignment Length: 619
• Identity: 121/619 - (19%)
• Similarity: 209/619 - (33%)
• Gaps: 196/619 - (31%)

  Fly    17 LLRFRNNPRGIKFREKLCNSFAHSNIHGMQHVFGEQH------LWQRCLWLAIVLGAVITGFSL- 74
            |:.|..:.|  :..:..||   ::.|||...:...:|      .| ..|||. ..|.:...|:|
Mouse    73 LIEFHRSYR--ELFQFFCN---NTTIHGAIRLVCSKHNRMKTAFW-AVLWLC-TFGMMYWQFALL 130

  Fly    75 ------YTVLM--HRHSEQLLVSLIETTQLPVYHIDFPAVAVCPWNHFNW--------------- 116
                  |.|.:  :.:|::|:               ||||.||..|.:.:
Mouse   131 FEEYFSYPVSLNINLNSDKLV---------------FPAVTVCTLNPYRYTEIKEDLEELDRITE 180

  Fly   117 -------------------QRAPSAFIRFLPRHPNAELR-------------------------- 136
                               :|..:..:|....||...||
Mouse   181 QTLFDLYKYNSSYTRQAGGRRRSTRDLRGALPHPLQRLRTPPPPNPARSARSASSSVRDNNPQVD 245

  Fly   137 ----------------ETFRQLLAS-MD-IMNFSNFNRIRILTKRNLTGISYLKMTDLMNFMTYR 183
                            :.|.|..:| :| :..:..|:.|.||::...|..: |:...|.:|:.
Mouse   246 RKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPDTSPA-LEEEALGSFIF-- 307

  Fly   184 CDELFVADSCVFDETPYDCCKLFVREQTVKGQCLVFNSMISENSRKKHLINQFYPHKLSTAGEDS 248
                    :|.|::.|.:..........:.|.|..||     |....:|.....|      |.::
Mouse   308 --------TCRFNQAPCNQANYSQFHHPMYGNCYTFN-----NKNNSNLWMSSMP------GVNN 353

  Fly   249 GLKFTINASYS-FMNNIDALTPFGMNLMI---KEPRQWSNEMMYHLYPDTENFVAVHPLVTETSP 309
            ||..|:....: |:..:..:|  |..:|:   .|| .:.::..:::.|..|..:::.....::..
Mouse   354 GLSLTLRTEQNDFIPLLSTVT--GARVMVHGQDEP-AFMDDGGFNVRPGVETSISMRKEALDSLG 415

  Fly   310 NTYEMSPKKRRCYFDDEKNPTFQNTSLTYNRENCLVVCLHLVVWKTCQCSLPAFLPPIDGVPECG 374
            ..|      ..|..:....|........|.::.|:..|....:.|.|.|:. .|.|...||..|
Mouse   416 GNY------GDCTENGSDVPVKNLYPSKYTQQVCIHSCFQENMIKKCGCAY-IFYPKPKGVEFC- 472

  Fly   375 INDAQCLGNNSDIFTYVKMGDQEKYINDSRQGHFCDCPDNCNSRLYEMSLNVRKLDYPK-NSTD- 437
                ..|..:|..:.|.|:  |..:..|| .|.|..|...|:...|::|....:  :|. .|.|
Mouse   473 ----DYLKQSSWGYCYYKL--QAAFSLDS-LGCFSKCRKPCSVTNYKLSAGYSR--WPSVKSQDW 528

  Fly   438 --QLIKAQVYY-------GQRVMTKIITKLKY---------TNIDLLANFGGIISLYIGASVMSF 484
              :::..|..|       |...:.....:|.|         |.:.||:|.|...||:.|:||:|.
Mouse   529 IFEMLSLQNNYTINNKRNGVAKLNIFFKELNYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVLSV 593

  Fly   485 IEL------LFVLGKLM---------WGFIRDAR 503
            :|:      |.|:..:|         |...|.||
Mouse   594 VEMAELIFDLLVITLIMLLHRFRSRYWSPGRGAR 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk19	NP_651708.2	ASC	37..489	CDD:459966	109/574 (19%)
Scnn1a	NP_035454.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..71
		ENaC	79..676	CDD:273304	119/613 (19%)
		Gating release of inhibition by proteolysis (GRIP), protease-sensitive region that is responsible for the proteolytic activation of the channel. /evidence=ECO:0000305|PubMed:18650438	200..270		8/69 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	211..244		4/32 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	637..699
		PY motif, recruits WW domain-containing proteins and is thereby required for ubiquitination and inhibition of the channel by NEDD4 and NEDD4L. /evidence=ECO:0000250|UniProtKB:P37088	669..673