DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk19 and asic-1

DIOPT Version :9

Sequence 1:	NP_651708.2	Gene:	ppk19 / 43489	FlyBaseID:	FBgn0039679	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_491214.3	Gene:	asic-1 / 191422	WormBaseID:	WBGene00022815	Length:	823	Species:	Caenorhabditis elegans

Alignment Length:	416	Identity:	87/416 - (20%)
Similarity:	143/416 - (34%)	Gaps:	128/416 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 SMDIMNFSNFNRIRILTKRNLTGISYLKMTDLMNFMTYRCDELFVADSCVFDETPYDCCKLFVRE 209
            :|:.|.|:    :..||:.....|||.|...:|.                        |....||
Worm   464 AMENMIFA----VDALTEEEKWKISYNKSDFIMK------------------------CSFNGRE 500

  Fly   210 QTVK-----------GQCLVFNSMISENSRKKHLINQFYPHKLSTAGEDSGLKFTINASYSFMNN 263
            ..||           |.|..:...:..|:.::             :|...||:..:     |:|.
Worm   501 CNVKHDFVEYLDPTYGACFTYGQKLGNNTNER-------------SGPAYGLRLEV-----FVNV 547

  Fly   264 IDAL---TPFGMNLMI----KEPRQWSNEMMYHLYPDTENFVAVHPLVTETSPNTYEM----SPK 317
            .:.|   ...|:.|.:    ::|           :|||..|.|....|:........|    :|
Worm   548 TEYLPTTEAAGVRLTVHATDEQP-----------FPDTLGFSAPTGFVSSFGIKLKSMVRLPAP- 600

  Fly   318 KRRCYFD---DEKNPTFQNTSLTYNRENCLVVCLHLVVWKTCQCSLPAFLPPIDGVPECGIND-- 377
                |.|   :.|...|..|...||.|.|...|:...:.|||.|..|.| ||......|.::|
Worm   601 ----YGDCVREGKTEDFIYTQKAYNTEGCQRSCIQKHLSKTCGCGDPRF-PPYRESKNCPVDDPY 660

  Fly   378 -AQCLGNNSDIFTYVKMGDQEKYINDSRQ-GHFCDCPDNCNSRLYEMSLNVRK------------ 428
             .:|:.|...:.|           .||:: |  |.|...||..:|.:|.:..:
Worm   661 KRECIKNEMHVAT-----------RDSKKLG--CSCKQPCNQDVYSVSYSASRWPAIAGDLSGCP 712

  Fly   429 --------LDYPKNSTDQLIKAQVYYGQRVMTKIITKLKYTNIDLLANFGGIISLYIGASVMSFI 485
                    |:|.:.....:   :||:.|.....::....|...:||::|||.:.|::|.||::..
Worm   713 LGMAAHHCLNYKREQGSMI---EVYFEQLNYESLLESEAYGWSNLLSDFGGQLGLWMGVSVITIG 774

  Fly   486 ELLFVLGKLMWGFIRDARIKLKEYTK 511
            |:.....::....|...|.|.:...|
Worm   775 EVACFFFEVFISLISSNRTKRRPARK 800

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk19	NP_651708.2	ASC	39..489	CDD:279230	83/392 (21%)
ppk19	NP_651708.2	AceK	116..>139	CDD:295079
asic-1	NP_491214.3	deg-1	16..779	CDD:273309	83/393 (21%)
		ASC	17..>104	CDD:279230
		ASC	<469..788	CDD:295594	81/397 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820