DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk19 and flr-1

DIOPT Version :9

Sequence 1:	NP_651708.2	Gene:	ppk19 / 43489	FlyBaseID:	FBgn0039679	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_510243.1	Gene:	flr-1 / 181468	WormBaseID:	WBGene00001465	Length:	638	Species:	Caenorhabditis elegans

Alignment Length:	500	Identity:	120/500 - (24%)
Similarity:	194/500 - (38%)	Gaps:	104/500 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 HGMQHVFGEQHLWQRCLWLAIVLGAVITGFSLYTVLMHRHSEQLLV------SLIET-TQLPVYH 100
            ||:..::.......|..|:.:||..:    ||:.:    ||..||:      :|.:| |.:|:..
Worm    29 HGLVRIYNSNTWPSRIFWVVVVLSCL----SLFMI----HSGYLLLGYHAKPTLFQTNTIVPMNG 85

  Fly   101 IDFPAVAVCPWNHFN-------------WQRAPSAFIRF-LPRHPNAELRETFRQLLASMDIMNF 151
            :.||.|.:|..|..|             |......|... ...|.:.:|.|  .|.|   :|||
Worm    86 LLFPEVTICNLNPLNTTKLEELNISKSTWTYIFGYFDEITTSEHKSTKLGE--EQFL---EIMN- 144

  Fly   152 SNFNRIRILTKRNLTGISYLKMTDLMNFMTYRCDELFVADSCVFD-ETPYDCCKLFVREQTVKGQ 215
             |:..   |||:.....::||.      ::..|:|.|:  ||.|. |..::||:....|.|..|.
Worm   145 -NYQE---LTKQEFNVKNFLKS------VSKSCEETFI--SCSFGREKLHNCCEHVTTEMTEVGV 197

  Fly   216 CLVFNSMISENSRKKHLINQFYPHKLSTAGEDSGLKFTINASYSFMNNIDAL---TPFGMNLMIK 277
            |...:     |..||:  .|:|      :|...|.:|.:|.:....::.|:|   ...|..:|:.
Worm   198 CFRLS-----NVNKKY--RQWY------SGNGFGWEFVLNGNNEIDDHADSLDFEPDRGFLIMVH 249

  Fly   278 EPRQWSNEMMYHLYPDTENF-VAVHP---LVTETSPNTYEMSPKKR--RCYFDDEKNPTFQNTSL 336
            |..:         ||...:: |||.|   |....|.....:..|..  .|    .|.....:|.:
Worm   250 ESEK---------YPKINSYGVAVSPDSQLHAAISMKNISLLDKANWGSC----SKGWNRNDTDV 301

  Fly   337 TYNRENCLVVCLHLVVWKTCQCSLPAFLPPIDGVPECGINDAQCLGNN-SDIFTYVKMGDQEKYI 400
            .|...:|.:.|....|...|.||..|:     ...|.|.||..|.... ...|..|:.
Worm   302 PYTATHCEIDCKLRKVRNLCGCSPLAY-----SARESGSNDTICTPYQIQQCFRKVRG------- 354

  Fly   401 NDSRQGHFCDCPDNCNSRLYEMSLNVRKLD-------YPKNSTDQLIKAQVYYGQRVMTKIITKL 458
            .|:|....||||..||...::::.:...||       ..|..:| :....:|:......:|..:.
Worm   355 LDNRWEDECDCPSECNMLEFDVTNSYSDLDGRSRGLSSSKVESD-ISHVSLYFSHVAYERIEQQK 418

  Fly   459 KYTNIDLLANFGGIISLYIGASVMSFIELLFVLGKLMWGFIRDAR 503
            :....|||:|..|.:.|::|.|.::.:|:...|.|.:||.:...|
Worm   419 QLQTADLLSNIAGSMGLFLGMSTVTLLEIFIYLFKSVWGTVNSTR 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk19	NP_651708.2	ASC	39..489	CDD:279230	115/484 (24%)
ppk19	NP_651708.2	AceK	116..>139	CDD:295079	5/23 (22%)
flr-1	NP_510243.1	ASC	22..450	CDD:279230	115/485 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I3586
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.970