DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk19 and Asic1

DIOPT Version :9

Sequence 1:	NP_651708.2	Gene:	ppk19 / 43489	FlyBaseID:	FBgn0039679	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001276720.1	Gene:	Asic1 / 11419	MGIID:	1194915	Length:	559	Species:	Mus musculus

Alignment Length:	515	Identity:	110/515 - (21%)
Similarity:	186/515 - (36%)	Gaps:	158/515 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 SFAHS-NIHGMQHVFGE------QHLWQRCLWLAIVLGAVI--TGFSLYTVLMHRHSEQLLVSLI 91
            :||:| .:||..|||.|      |.||  .:...|.|||.:  .|..:...|.:.|  ..|:..:
Mouse    65 AFANSCTLHGASHVFVEGGPGPRQALW--AVAFVIALGAFLCQVGDRVAYYLSYPH--VTLLDEV 125

  Fly    92 ETTQLPVYHIDFPAVAVCPWNHFNWQRAPSAFIRFL-----------------PRHPNAELRETF 139
            .||:|.     ||||..|..|.....:.....:.:|                 |..|.|...|.|
Mouse   126 ATTELV-----FPAVTFCNTNAVRLSQLSYPDLLYLAPMLGLDESDDPGVPLAPPGPEAFSGEPF 185

  Fly   140 RQLLASMDIMNFSNFNRIRILTKRNLTGISYLKMTDLMNFMTYRCDELFVADSCVFDETPYDCCK 204
                   ::..|  :||            |..::.|::.:.:|          |.....|::...
Mouse   186 -------NLHRF--YNR------------SCHRLEDMLLYCSY----------CGGPCGPHNFSV 219

  Fly   205 LFVREQTVKGQCLVFNSMISENSRKKHLINQFYPHKLSTAGEDSGLKFTINASYSFMNNIDALTP 269
            :|.|    .|:|..|||  .::.|.:        .|....|..:||:..::...      |...|
Mouse   220 VFTR----YGKCYTFNS--GQDGRPR--------LKTMKGGTGNGLEIMLDIQQ------DEYLP 264

  Fly   270 F-----------GMNLMI---KEPRQWSNEMMYHLYPDTENFVAVHP--LVTETSP----NTYEM 314
            .           |:.:.|   .|| .:.:::.:.:.|..:.||:...  |:...||    |...|
Mouse   265 VWGETDETSFEAGIKVQIHSQDEP-PFIDQLGFGVAPGFQTFVSCQEQRLIYLPSPWGTCNAVTM 328

  Fly   315 SPKKRRCYFDDEKNPTFQNTSLTYNRENCLVVCLHLVVWKTCQCSLPAFLPPIDGVPECGIND-A 378
            ...    :||            :|:...|.:.|....:.:.|.|.: ..:|  ...|.|.... .
Mouse   329 DSD----FFD------------SYSITACRIDCETRYLVENCNCRM-VHMP--GDAPYCTPEQYK 374

  Fly   379 QCLGNNSDIFTYVKMGDQEKYINDSRQGHFCDCPDNCNSRLYEMSLNVRKLDYPKNSTDQLI--- 440
            :|.....|   ::...|||          :|.|...||...|...|::.|:  |..::.:.:
Mouse   375 ECADPALD---FLVEKDQE----------YCVCEMPCNLTRYGKELSMVKI--PSKASAKYLAKK 424

  Fly   441 --KAQVYYGQRVMTKII--TKLKYTNID---------LLANFGGIISLYIGASVMSFIEL 487
              |::.|.|:.::...|  ..|.|..|:         ||.:.||.:.|:||||:::.:||
Mouse   425 FNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLEL 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk19	NP_651708.2	ASC	39..489	CDD:279230	108/512 (21%)
ppk19	NP_651708.2	AceK	116..>139	CDD:295079	5/39 (13%)
Asic1	NP_001276720.1	ASC	63..541	CDD:295594	110/515 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920